The pharmacology of DMP696 and DMP904, non-peptidergic CRF1 receptor antagonists. (Q36114372)

12 August 2017

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title

The pharmacology of DMP696 and DMP904, non-peptidergic CRF1 receptor antagonists (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6741745&resulttype=core&format=json

12 May 2020

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Yu-Wen Li

1

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12 May 2020

Lawrence Fitzgerald

2

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12 May 2020

Harvey Wong

3

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12 May 2020

Snjezana Lelas

4

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12 May 2020

Ge Zhang

5

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12 May 2020

Mark D Lindner

6

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12 May 2020

Tanya Wallace

7

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12 May 2020

John McElroy

8

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12 May 2020

Nicholas J Lodge

9

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12 May 2020

Paul Gilligan

10

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12 May 2020

Robert Zaczek

11

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12 May 2020

language of work or name

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1 January 2005

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CNS Neuroscience & Therapeutics

12 August 2017

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6741745&resulttype=core&format=json

12 May 2020

volume

11

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12 May 2020

issue

1

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12 May 2020

page(s)

21-52

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The anxiolytic CRF(1) antagonist DMP696 fails to function as a discriminative stimulus and does not substitute for chlordiazepoxide in rats

12 May 2020

cites work

1 reference

Crossref

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2005.TB00034.X

Non-peptide corticotropin-releasing hormone antagonists: syntheses and structure-activity relationships of 2-anilinopyrimidines and -triazines

21 January 2018

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12 December 2020

Role of corticotropin-releasing factor and urocortin within the basolateral amygdala of rats in anxiety and panic responses.

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12 December 2020

Receptor binding, behavioral, and electrophysiological profiles of nonpeptide corticotropin-releasing factor subtype 1 receptor antagonists CRA1000 and CRA1001.

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12 December 2020

Autoradiographic and in situ hybridization localization of corticotropin-releasing factor 1 and 2 receptors in nonhuman primate brain.

1 reference

12 December 2020

In vitro pharmacological profile of nonpeptide CRF1 receptor antagonists, CRA1000 and CRA1001

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12 December 2020

Modulation of learning and anxiety by corticotropin-releasing factor (CRF) and stress: differential roles of CRF receptors 1 and 2

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12 December 2020

Stress-induced behaviors require the corticotropin-releasing hormone (CRH) receptor, but not CRH.

1 reference

12 December 2020

Chronic administration of the non-peptide CRH type 1 receptor antagonist antalarmin does not blunt hypothalamic-pituitary-adrenal axis responses to acute immobilization stress.

1 reference

12 December 2020

Reduced anxiety-like and cognitive performance in mice lacking the corticotropin-releasing factor receptor 1.

1 reference

12 December 2020

Differential effects of two corticotropin-releasing factor antagonists on conditioned defeat in male Syrian hamsters (Mesocricetus auratus)

1 reference

12 December 2020

Corticotropin-releasing hormone receptor subtypes and emotion

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12 December 2020

Corticotropin-releasing hormone receptors mediate consensus interferon-alpha YM643-induced depression-like behavior in mice

1 reference

12 December 2020

4-(1,3-Dimethoxyprop-2-ylamino)-2,7-dimethyl-8-(2, 4-dichlorophenyl)pyrazolo[1,5-a]-1,3,5-triazine: a potent, orally bioavailable CRF(1) receptor antagonist

1 reference

12 December 2020

Abnormal adaptations to stress and impaired cardiovascular function in mice lacking corticotropin-releasing hormone receptor-2.

1 reference

12 December 2020

Mice deficient for corticotropin-releasing hormone receptor-2 display anxiety-like behaviour and are hypersensitive to stress.

1 reference

12 December 2020

Deletion of crhr2 reveals an anxiolytic role for corticotropin-releasing hormone receptor-2.

1 reference

12 December 2020

Corticotropin releasing factor (CRF) receptor modulators: progress and opportunities for new therapeutic agents

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12 December 2020

Effects of the CRF(1) receptor antagonist, CP 154,526, in the separation-induced vocalization anxiolytic test in rat pups.

1 reference

12 December 2020

Oral administration of a corticotropin-releasing hormone receptor antagonist significantly attenuates behavioral, neuroendocrine, and autonomic responses to stress in primates

1 reference

12 December 2020

Effects of the high-affinity corticotropin-releasing hormone receptor 1 antagonist R121919 in major depression: the first 20 patients treated

1 reference

12 December 2020

Chronic administration of the selective corticotropin-releasing factor 1 receptor antagonist CP-154,526: behavioral, endocrine and neurochemical effects in the rat

1 reference

12 December 2020

Corticotropin-releasing factor antagonists, binding-protein and receptors: implications for central nervous system disorders

1 reference

12 December 2020

The discovery of 4-(3-pentylamino)-2,7-dimethyl-8-(2-methyl-4-methoxyphenyl)-pyrazolo-[1 ,5-a]-pyrimidine: a corticotropin-releasing factor (hCRF1) antagonist

1 reference

12 December 2020

Suppression of conditioned fear by administration of CRF receptor antagonist CP-154,526.

1 reference

12 December 2020

Characterization of three corticotropin-releasing factor receptors in catfish: a novel third receptor is predominantly expressed in pituitary and urophysis.

1 reference

12 December 2020

Involvement of corticotropin-releasing factor in the retrieval process of fear-conditioned ultrasonic vocalization in rats.

1 reference

12 December 2020

The anxiolytic effect of the CRH(1) receptor antagonist R121919 depends on innate emotionality in rats.

1 reference

12 December 2020

Anxiolytic-like effects of 5-HT(1A) agonists in drug-naive and in benzodiazepine-experienced rats.

1 reference

12 December 2020

Attenuation of fear conditioning by antisense inhibition of brain corticotropin releasing factor-2 receptor.

1 reference

12 December 2020

Corticotropin-releasing hormone in depression and post-traumatic stress disorder

1 reference

12 December 2020

The effects of CRA 1000, a non-peptide antagonist of corticotropin-releasing factor receptor type 1, on adaptive behaviour in the rat.

1 reference

12 December 2020

Antagonism of CRF(2) receptors produces anxiolytic behavior in animal models of anxiety.

1 reference

12 December 2020

Expression of corticotropin-releasing hormone type 1 receptor in paraventricular nucleus after acute stress.

1 reference

12 December 2020

Involvement of the hypothalamus-pituitary-adrenal axis in antidepressant activity of corticotropin-releasing factor subtype 1 receptor antagonists in the rat learned helplessness test.

1 reference

12 December 2020

Involvement of corticotropin-releasing factor subtype 1 receptor in the acquisition phase of learned helplessness in rats.

1 reference

12 December 2020

Anxiolytic properties of the selective, non-peptidergic CRF(1) antagonists, CP154,526 and DMP695: a comparison to other classes of anxiolytic agent

1 reference

12 December 2020

Brain pharmacokinetics of a nonpeptidic corticotropin-releasing factor receptor antagonist

1 reference

12 December 2020

Role of CRF(1) and CRF(2) receptors in fear and anxiety

1 reference

12 December 2020

Cognitive and sedative effects of benzodiazepine use.

1 reference

12 December 2020

The CRF peptide family and their receptors: yet more partners discovered

1 reference

12 December 2020

4-(2-Chloro-4-methoxy-5-methylphenyl)-N-[(1S)-2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl]5-methyl-N-(2-propynyl)-1,3-thiazol-2-amine hydrochloride (SSR125543A): a potent and selective corticotrophin-releasing factor(1) receptor antagonist. I. Bi

1 reference

12 December 2020

4-(2-Chloro-4-methoxy-5-methylphenyl)-N-[(1S)-2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl]5-methyl-N-(2-propynyl)-1, 3-thiazol-2-amine hydrochloride (SSR125543A), a potent and selective corticotrophin-releasing factor(1) receptor antagonist. II.

1 reference

12 December 2020

Effects of a non-peptide CRF antagonist (DMP696) on the behavioral and endocrine sequelae of maternal separation.

1 reference

12 December 2020

Brain penetrance, receptor occupancy and antistress in vivo efficacy of a small molecule corticotropin releasing factor type I receptor selective antagonist

1 reference

12 December 2020

Generalised anxiety disorder: treatment options

1 reference

12 December 2020

The CRH1 receptor antagonist R121919 attenuates stress-elicited sleep disturbances in rats, particularly in those with high innate anxiety

1 reference

12 December 2020

Effects of antalarmin, a CRF type 1 receptor antagonist, on anxiety-like behavior and motor activation in the rat.

1 reference

12 December 2020

The CRF(1) receptor antagonist DMP696 produces anxiolytic effects and inhibits the stress-induced hypothalamic-pituitary-adrenal axis activation without sedation or ataxia in rats

1 reference

12 December 2020

Corticotropin-releasing factor receptors couple to multiple G-proteins to activate diverse intracellular signaling pathways in mouse hippocampus: role in neuronal excitability and associative learning.

1 reference

12 December 2020

The corticotropin-releasing factor1 receptor antagonist R121919 attenuates the behavioral and endocrine responses to stress

1 reference

12 December 2020

The pharmacology of CP-154,526, a non-peptide antagonist of the CRH1 receptor: a review

1 reference

12 December 2020

Corticotropin-releasing hormone modulators and depression

1 reference

12 December 2020

Pharmacological characterization of a novel nonpeptide antagonist radioligand, (+/-)-N-[2-methyl-4-methoxyphenyl]-1-(1-(methoxymethyl) propyl)-6-methyl-1H-1,2,3-triazolo[4,5-c]pyridin-4-amine ([3H]SN003) for corticotropin-releasing factor1 receptors

1 reference

12 December 2020

Receptor occupancy of nonpeptide corticotropin-releasing factor 1 antagonist DMP696: correlation with drug exposure and anxiolytic efficacy

1 reference

12 December 2020

The high-affinity non-peptide CRH1 receptor antagonist R121919 attenuates stress-induced alterations in plasma oxytocin, prolactin, and testosterone secretion in rats

1 reference

12 December 2020

Non-peptidic CRF1 receptor antagonists for the treatment of anxiety, depression and stress disorders

1 reference

12 December 2020

Effects of the selective nonpeptide corticotropin-releasing factor receptor 1 antagonist antalarmin in the chronic mild stress model of depression in mice.

1 reference

12 December 2020

Increased depression-like behaviors in corticotropin-releasing factor receptor-2-deficient mice: sexually dichotomous responses.

1 reference

12 December 2020

Role of corticotropin releasing factor (CRF) receptors 1 and 2 in CRF-potentiated acoustic startle in mice

1 reference

12 December 2020

A novel water-soluble selective CRF1 receptor antagonist, NBI 35965, blunts stress-induced visceral hyperalgesia and colonic motor function in rats

1 reference

12 December 2020

Limbic corticotropin-releasing hormone receptor 1 mediates anxiety-related behavior and hormonal adaptation to stress.

1 reference

12 December 2020

The central distribution of a corticotropin-releasing factor (CRF)-binding protein predicts multiple sites and modes of interaction with CRF

1 reference

12 December 2020

Animal behavioural studies in the evaluation of antidepressant drugs

1 reference

12 December 2020

Treatment of depression with the CRH-1-receptor antagonist R121919: endocrine changes and side effects

1 reference

12 December 2020

Neuropeptide systems as novel therapeutic targets for depression and anxiety disorders

1 reference

12 December 2020

Anxiolytic-like effects of the corticotropin-releasing factor1 (CRF1) antagonist DMP904 [4-(3-pentylamino)-2,7-dimethyl-8-(2-methyl-4-methoxyphenyl)-pyrazolo-[1,5-a]-pyrimidine] administered acutely or chronically at doses occupying central CRF1 rec

1 reference

12 December 2020

CRF and CRF receptors: role in stress responsivity and other behaviors

1 reference

12 December 2020

Anxiolytic- and antidepressant-like profile of a new CRF1 receptor antagonist, R278995/CRA0450.

1 reference

12 December 2020

Treatment with the CRH1-receptor-antagonist R121919 improves sleep-EEG in patients with depression

1 reference

12 December 2020

Corticotropin-releasing hormone antagonists, astressin B and antalarmin: differing profiles of activity in rhesus monkeys

1 reference

12 December 2020

Differential regulation of behavioral, genomic, and neuroendocrine responses by CRF infusions in rats

1 reference

12 December 2020

Effects of the CRF1 antagonist SSR125543A on aggressive behaviors in hamsters

1 reference

12 December 2020

Effects of CRF1 receptor antagonists and benzodiazepines in the Morris water maze and delayed non-matching to position tests.

1 reference

12 December 2020

Physiology and pharmacology of corticotropin-releasing factor

1 reference

12 December 2020

Diazepam impairs place learning in the Morris water maze

1 reference

12 December 2020

Corticotropin-releasing factor modulates defensive-withdrawal and exploratory behavior in rats

1 reference

12 December 2020

Validation of open:closed arm entries in an elevated plus-maze as a measure of anxiety in the rat

1 reference

12 December 2020

Reciprocal changes in corticotropin-releasing factor (CRF)-like immunoreactivity and CRF receptors in cerebral cortex of Alzheimer's disease

1 reference

12 December 2020

Chlordiazepoxide, an anxiolytic benzodiazepine, impairs place navigation in rats.

1 reference

12 December 2020

The tail suspension test: a new method for screening antidepressants in mice

1 reference

12 December 2020

Characterization of a 41-Residue Ovine Hypothalamic Peptide That Stimulates Secretion of Corticotropin and β-Endorphin

1 reference

12 December 2020

Specificity of the learned helplessness model of depression.

1 reference

12 December 2020

Displacement of corticotropin releasing factor from its binding protein as a possible treatment for Alzheimer's disease

1 reference

12 December 2020

CRF2 alpha and CRF2 beta receptor mRNAs are differentially distributed between the rat central nervous system and peripheral tissues

1 reference

12 December 2020

Identification of a novel murine receptor for corticotropin-releasing hormone expressed in the heart

1 reference

12 December 2020

Diazepam impairs place learning in native but not in maze-experienced rats in the Morris water maze.

1 reference

12 December 2020

Memory functions, alprazolam and exposure therapy: a controlled longitudinal study of agoraphobia with panic disorder

1 reference

12 December 2020

Overproduction of corticotropin-releasing factor in transgenic mice: a genetic model of anxiogenic behavior.

1 reference

12 December 2020

Active behaviors in the rat forced swimming test differentially produced by serotonergic and noradrenergic antidepressants

1 reference

12 December 2020

CRH overproduction in transgenic mice: behavioral and immune system modulation

1 reference

12 December 2020

CP-154,526: a potent and selective nonpeptide antagonist of corticotropin releasing factor receptors.

1 reference

12 December 2020

A non peptidic corticotropin releasing factor receptor antagonist attenuates fever and exhibits anxiolytic-like activity

1 reference

12 December 2020

Design and synthesis of a series of non-peptide high-affinity human corticotropin-releasing factor1 receptor antagonists

1 reference

12 December 2020

In vivo and in vitro characterization of antalarmin, a nonpeptide corticotropin-releasing hormone (CRH) receptor antagonist: suppression of pituitary ACTH release and peripheral inflammation

1 reference

12 December 2020

Antidepressant-like effects of CP-154,526, a selective CRF1 receptor antagonist.

1 reference

12 December 2020

Synthesis and oral efficacy of a 4-(butylethylamino)pyrrolo[2,3-d]pyrimidine: a centrally active corticotropin-releasing factor1 receptor antagonist.

1 reference

12 December 2020

Social interaction: responses to chlordiazepoxide and the loss of isolation-reared effects with paired-housing

1 reference

12 December 2020

Chronic effects of a nonpeptide corticotropin-releasing hormone type I receptor antagonist on pituitary-adrenal function, body weight, and metabolic regulation.

1 reference

12 December 2020

Impaired stress response and reduced anxiety in mice lacking a functional corticotropin-releasing hormone receptor 1.

1 reference

12 December 2020

Corticotropin-releasing hormone receptor (type I) antisense targeting reduces anxiety.

1 reference

12 December 2020

Corticotropin releasing factor receptor 1-deficient mice display decreased anxiety, impaired stress response, and aberrant neuroendocrine development

1 reference

12 December 2020

Characterization of [125I]sauvagine binding to CRH2 receptors: membrane homogenate and autoradiographic studies

1 reference

12 December 2020

Characterization of the behavioral profile of the non-peptide CRF receptor antagonist CP-154,526 in anxiety models in rodents. Comparison with diazepam and buspirone.

1 reference

12 December 2020

Molecular identification and analysis of a novel human corticotropin-releasing factor (CRF) receptor: the CRF2gamma receptor

1 reference

12 December 2020

Proactive interference and temporal context encoding after diazepam intake.

1 reference

12 December 2020

The Impact of the Nonpeptide Corticotropin-Releasing Hormone Antagonist Antalarmin on Behavioral and Endocrine Responses to Stress1

1 reference

12 December 2020

In vivo and in vitro characterization of antalarmin, a nonpeptide corticotropin-releasing hormone (CRH) receptor antagonist: suppression of pituitary ACTH release and peripheral inflammation

1 reference

12 December 2020

The impact of the nonpeptide corticotropin-releasing hormone antagonist antalarmin on behavioral and endocrine responses to stress

1 reference

12 December 2020

10.1111/J.1527-3458.2005.TB00034.X

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6741745&resulttype=core&format=json

12 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6741745&resulttype=core&format=json

12 May 2020

1 reference