Tumor necrosis factor-α synthesis inhibitor 3,6'-dithiothalidomide attenuates markers of inflammation, Alzheimer pathology and behavioral deficits in animal models of neuroinflammation and Alzheimer's disease (Q36118204)

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English	Tumor necrosis factor-α synthesis inhibitor 3,6'-dithiothalidomide attenuates markers of inflammation, Alzheimer pathology and behavioral deficits in animal models of neuroinflammation and Alzheimer's disease	scientific article

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2 February 2020

Tumor necrosis factor-α synthesis inhibitor 3,6'-dithiothalidomide attenuates markers of inflammation, Alzheimer pathology and behavioral deficits in animal models of neuroinflammation and Alzheimer's disease (English)

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2 February 2020

Alzheimer's disease

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Henriette van Praag

5

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2 February 2020

author name string

David Tweedie

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Ryan A Ferguson

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2 February 2020

Kelly Fishman

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Kathryn A Frankola

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Harold W Holloway

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Weiming Luo

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2 February 2020

Yazhou Li

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2 February 2020

Luca Caracciolo

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Sergio Barlati

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2 February 2020

Balmiki Ray

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2 February 2020

Debomoy K Lahiri

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Francesca Bosetti

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Nigel H Greig

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Susanna Rosi

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29 May 2012

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2 February 2020

Journal of Neuroinflammation

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2 February 2020

9

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106

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2 February 2020

https://scigraph.springernature.com/pub.10.1186/1742-2094-9-106

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TNF-α protein synthesis inhibitor restores neuronal function and reverses cognitive deficits induced by chronic neuroinflammation.

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Deciphering the physiology underlying the rapid clinical effects of perispinal etanercept in Alzheimer's disease

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2 October 2017

Ablation of TNF-RI/RII expression in Alzheimer's disease mice leads to an unexpected enhancement of pathology: implications for chronic pan-TNF-α suppressive therapeutic strategies in the brain

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Rivastigmine lowers Aβ and increases sAPPα levels, which parallel elevated synaptic markers and metabolic activity in degenerating primary rat neurons

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2 October 2017

Thalidomide Analogues Suppress Lipopolysaccharide-Induced Synthesis of TNF-α and Nitrite, an Intermediate of Nitric Oxide, in a Cellular Model of Inflammation

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2 October 2017

Chronic neuroinflammation impacts the recruitment of adult-born neurons into behaviorally relevant hippocampal networks

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2 October 2017

Tumor necrosis factor-α synthesis inhibitor, 3,6'-dithiothalidomide, reverses behavioral impairments induced by minimal traumatic brain injury in mice

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2 October 2017

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2 October 2017

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Targeting TNF-α to elucidate and ameliorate neuroinflammation in neurodegenerative diseases

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Mechanisms of TNFα regulation in uveitis: focus on RNA-binding proteins

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GLP-1 receptor stimulation reduces amyloid-beta peptide accumulation and cytotoxicity in cellular and animal models of Alzheimer's disease.

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Treatment with a C5aR antagonist decreases pathology and enhances behavioral performance in murine models of Alzheimer's disease

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Accuracy of hippocampal network activity is disrupted by neuroinflammation: rescue by memantine

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Rapid cognitive improvement in Alzheimer's disease following perispinal etanercept administration

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A Oligomer-Induced Aberrations in Synapse Composition, Shape, and Density Provide a Molecular Basis for Loss of Connectivity in Alzheimer's Disease

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Tumor necrosis factor (TNF)-mediated neuroprotection against glutamate-induced excitotoxicity is enhanced by N-methyl-D-aspartate receptor activation. Essential role of a TNF receptor 2-mediated phosphatidylinositol 3-kinase-dependent NF-kappa B pat

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2 October 2017

Thiothalidomides: Novel Isosteric Analogues of Thalidomide with Enhanced TNF-α Inhibitory Activity

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2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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2 July 2018

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2 July 2018

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2 July 2018

Thalidomide exerts its inhibitory action on tumor necrosis factor alpha by enhancing mRNA degradation

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2 July 2018

Reactive microglia in patients with senile dementia of the Alzheimer type are positive for the histocompatibility glycoprotein HLA-DR.

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2 July 2018

Involvement of rat hippocampal astrocytes in β-amyloid-induced angiogenesis and neuroinflammation.

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23 September 2018

Females exhibit more extensive amyloid, but not tau, pathology in an Alzheimer transgenic model.

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23 September 2018

Pro-inflammatory cytokines modulate glial apolipoprotein E secretion.

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23 September 2018

Ccr2 deficiency impairs microglial accumulation and accelerates progression of Alzheimer-like disease.

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23 September 2018

Tumor necrosis factor alpha and interleukin 10 promoter region polymorphisms and risk of late-onset Alzheimer disease.

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23 September 2018

Implanted cannula-mediated repetitive administration of Abeta25-35 into the mouse cerebral ventricle effectively impairs spatial working memory.

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23 September 2018

TNF polymorphisms in Alzheimer disease and functional implications on CSF beta-amyloid levels.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3405480

23 September 2018

Intraneuronal Abeta causes the onset of early Alzheimer's disease-related cognitive deficits in transgenic mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3405480

23 September 2018

Thalidomide-based TNF-alpha inhibitors for neurodegenerative diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3405480

23 September 2018

Involvement of tumor necrosis factor alpha in hippocampal development and function.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3405480

23 September 2018

Role of cytokines in the gene expression of amyloid β–protein precursor: Identification of a 5'-UTR-Binding nuclear factor and its implications in Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3405480

23 September 2018

Chronic brain inflammation results in cell loss in the entorhinal cortex and impaired LTP in perforant path-granule cell synapses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3405480

23 September 2018

Non-steroidal anti-inflammatory drugs stimulate secretion of non-amyloidogenic precursor protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3405480

23 September 2018

Target depletion of distinct tumor necrosis factor receptor subtypes reveals hippocampal neuron death and survival through different signal transduction pathways.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3405480

23 September 2018

Neurodegenerative and neuroprotective effects of tumor Necrosis factor (TNF) in retinal ischemia: opposite roles of TNF receptor 1 and TNF receptor 2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3405480

23 September 2018

Neuroinflammation-induced acceleration of amyloid deposition in the APPV717F transgenic mouse

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3405480

23 September 2018

Intracerebral production of tumor necrosis factor-alpha, a local neuroprotective agent, in Alzheimer disease and vascular dementia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3405480

23 September 2018

Amnesia induced in mice by centrally administered beta-amyloid peptides involves cholinergic dysfunction.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3405480

23 September 2018

Transforming growth factor beta mediates increase of mature transmembrane amyloid precursor protein in microglial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3405480

23 September 2018

Fluoro-Jade: novel fluorochromes for detecting toxicant-induced neuronal degeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/22642825

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glial cells and inflammation in Parkinson's disease: a role in neurodegeneration?

1 reference

https://pubmed.ncbi.nlm.nih.gov/22642825

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Unresponsiveness of MyD88-deficient mice to endotoxin

1 reference

https://pubmed.ncbi.nlm.nih.gov/22642825

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1186/1742-2094-9-106

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22642825%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

Dimensions Publication ID

0 references

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22642825%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22642825%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

ResearchGate publication ID

0 references

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