Lipolytic products activate peroxisome proliferator-activated receptor (PPAR) α and δ in brown adipocytes to match fatty acid oxidation with supply (Q36127114)

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English	Lipolytic products activate peroxisome proliferator-activated receptor (PPAR) α and δ in brown adipocytes to match fatty acid oxidation with supply	scientific article

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scholarly article

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Europe PubMed Central

PMC publication ID

12 August 2017

Lipolytic products activate peroxisome proliferator-activated receptor (PPAR) α and δ in brown adipocytes to match fatty acid oxidation with supply (English)

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

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1 reference

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author name string

Emilio P Mottillo

1

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

Ainsley E Bloch

2

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Europe PubMed Central

PMC publication ID

12 August 2017

Todd Leff

3

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Europe PubMed Central

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12 August 2017

James G Granneman

4

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Europe PubMed Central

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12 August 2017

language of work or name

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publication date

8 June 2012

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Europe PubMed Central

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12 August 2017

Journal of Biological Chemistry

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Europe PubMed Central

PMC publication ID

12 August 2017

287

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Europe PubMed Central

PMC publication ID

12 August 2017

30

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

25038-25048

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

Assessment of oxidative metabolism in brown fat using PET imaging

1 reference

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In vivo identification of bipotential adipocyte progenitors recruited by β3-adrenoceptor activation and high-fat feeding

1 reference

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2 October 2017

NT-PGC-1α protein is sufficient to link β3-adrenergic receptor activation to transcriptional and physiological components of adaptive thermogenesis

1 reference

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2 October 2017

The nuclear receptor PPARβ/δ programs muscle glucose metabolism in cooperation with AMPK and MEF2

1 reference

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2 October 2017

Peroxisome proliferator-activated receptor α (PPARα) induces PPARγ coactivator 1α (PGC-1α) gene expression and contributes to thermogenic activation of brown fat: involvement of PRDM16.

1 reference

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2 October 2017

ATGL-mediated fat catabolism regulates cardiac mitochondrial function via PPAR-α and PGC-1.

1 reference

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2 October 2017

Desnutrin/ATGL is regulated by AMPK and is required for a brown adipose phenotype

1 reference

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2 October 2017

The implication of brown adipose tissue for humans

1 reference

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2 October 2017

Intracellular fatty acids suppress β-adrenergic induction of PKA-targeted gene expression in white adipocytes

1 reference

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2 October 2017

Adipose triglyceride lipase is a major hepatic lipase that regulates triacylglycerol turnover and fatty acid signaling and partitioning

1 reference

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Weight loss and lipolysis promote a dynamic immune response in murine adipose tissue

1 reference

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beta3-adrenergic receptor induction of adipocyte inflammation requires lipolytic activation of stress kinases p38 and JNK

1 reference

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VLDL hydrolysis by LPL activates PPAR-alpha through generation of unbound fatty acids

1 reference

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2 October 2017

Transcriptional control of brown fat development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3408177

2 October 2017

Rescue of cardiomyopathy in peroxisome proliferator-activated receptor-alpha transgenic mice by deletion of lipoprotein lipase identifies sources of cardiac lipids and peroxisome proliferator-activated receptor-alpha activators

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3408177

2 October 2017

PPARdelta is a fatty acid sensor that enhances mitochondrial oxidation in insulin-secreting cells and protects against fatty acid-induced dysfunction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3408177

2 October 2017

Perilipin controls lipolysis by regulating the interactions of AB-hydrolase containing 5 (Abhd5) and adipose triglyceride lipase (Atgl).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3408177

2 October 2017

Peroxisome proliferator-activated receptor beta/delta (PPARbeta/delta) but not PPARalpha serves as a plasma free fatty acid sensor in liver

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3408177

2 October 2017

Identification of a physiologically relevant endogenous ligand for PPARalpha in liver

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3408177

2 October 2017

Combinatorial transcription factor regulation of the cyclic AMP-response element on the Pgc-1alpha promoter in white 3T3-L1 and brown HIB-1B preadipocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3408177

2 October 2017

Twist-1 is a PPARdelta-inducible, negative-feedback regulator of PGC-1alpha in brown fat metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3408177

2 October 2017

Hepatic triacylglycerol hydrolysis regulates peroxisome proliferator-activated receptor alpha activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3408177

2 October 2017

Adipose overexpression of desnutrin promotes fatty acid use and attenuates diet-induced obesity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3408177

2 October 2017

FSP27 contributes to efficient energy storage in murine white adipocytes by promoting the formation of unilocular lipid droplets

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3408177

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Analysis of mitochondrial function in situ in permeabilized muscle fibers, tissues and cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3408177

2 October 2017

Fatty acid-binding proteins: role in metabolic diseases and potential as drug targets

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3408177

2 October 2017

Hepatic overexpression of hormone-sensitive lipase and adipose triglyceride lipase promotes fatty acid oxidation, stimulates direct release of free fatty acids, and ameliorates steatosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3408177

2 October 2017

Comprehensive analysis of PPARalpha-dependent regulation of hepatic lipid metabolism by expression profiling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3408177

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Transcriptional control of mitochondrial energy metabolism through the PGC1 coactivators.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3408177

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Three members of the human pyruvate dehydrogenase kinase gene family are direct targets of the peroxisome proliferator-activated receptor beta/delta

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3408177

2 October 2017

PPARs and their metabolic modulation: new mechanisms for transcriptional regulation?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3408177

2 October 2017

Complementary action of the PGC-1 coactivators in mitochondrial biogenesis and brown fat differentiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3408177

2 October 2017

PGC-1alpha deficiency causes multi-system energy metabolic derangements: muscle dysfunction, abnormal weight control and hepatic steatosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3408177

2 October 2017

Minireview: lipid metabolism, metabolic diseases, and peroxisome proliferator-activated receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3408177

2 October 2017

Peroxisome-Proliferator-Activated Receptor δ Activates Fat Metabolism to Prevent Obesity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3408177

2 October 2017

Hormone-sensitive lipase: control of intracellular tri-(di-)acylglycerol and cholesteryl ester hydrolysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3408177

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Regulatory motifs for CREB-binding protein and Nfe2l2 transcription factors in the upstream enhancer of the mitochondrial uncoupling protein 1 gene

1 reference

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Perilipin ablation results in a lean mouse with aberrant adipocyte lipolysis, enhanced leptin production, and resistance to diet-induced obesity

1 reference

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A history of the first uncoupling protein, UCP1.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3408177

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CREB activation induces adipogenesis in 3T3-L1 cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3408177

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A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3408177

2 October 2017

Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors alpha and delta

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3408177

2 October 2017

Role of hormone-sensitive lipase in beta-adrenergic remodeling of white adipose tissue

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3408177

2 July 2018

Analysis of lipolytic protein trafficking and interactions in adipocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3408177

2 July 2018

High-throughput assay to measure oxygen consumption in digitonin-permeabilized cells of patients with mitochondrial disorders.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3408177

23 September 2018

DNA extraction procedures meaningfully influence qPCR-based mtDNA copy number determination

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Maintenance of cardiac energy metabolism by histone deacetylase 3 in mice

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23 September 2018

Absence of perilipin results in leanness and reverses obesity in Lepr(db/db) mice

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3408177

23 September 2018

Peroxisome proliferator-activated receptor alpha activates transcription of the brown fat uncoupling protein-1 gene. A link between regulation of the thermogenic and lipid oxidation pathways in the brown fat cell.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3408177

23 September 2018

An upstream enhancer regulating brown-fat-specific expression of the mitochondrial uncoupling protein gene

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23 September 2018

Noradrenergic stimulation of mitochondriogenesis in brown adipocytes differentiating in culture

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https://pubmed.ncbi.nlm.nih.gov/22685301

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabolic and cellular plasticity in white adipose tissue I: effects of beta3-adrenergic receptor activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/22685301

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analysis of mitochondrial function using phosphorescent oxygen-sensitive probes

1 reference

https://pubmed.ncbi.nlm.nih.gov/22685301

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabolic and cellular plasticity in white adipose tissue II: role of peroxisome proliferator-activated receptor-alpha

1 reference

https://pubmed.ncbi.nlm.nih.gov/22685301

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M112.374041

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

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