Designer enediynes generate DNA breaks, interstrand cross-links, or both, with concomitant changes in the regulation of DNA damage responses (Q36140618)

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scholarly article

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English	Designer enediynes generate DNA breaks, interstrand cross-links, or both, with concomitant changes in the regulation of DNA damage responses	scholarly article

Statements

scholarly article

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

Designer enediynes generate DNA breaks, interstrand cross-links, or both, with concomitant changes in the regulation of DNA damage responses (English)

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

0 references

author name string

Daniel R Kennedy

1

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

Jianhua Ju

2

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

Ben Shen

3

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

Terry A Beerman

4

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

language of work or name

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publication date

31 October 2007

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

number of pages

6

1 reference

based on heuristic

inferred from page(s)

Proceedings of the National Academy of Sciences of the United States of America

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

104

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

45

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

17632-17637

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

describes a project that uses

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2077023/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

Single chemical modifications of the C-1027 enediyne core, a radiomimetic antitumor drug, affect both drug potency and the role of ataxia-telangiectasia mutated in cellular responses to DNA double-strand breaks

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2077023

2 October 2017

The radiomimetic enediyne C-1027 induces unusual DNA damage responses to double-strand breaks

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2077023

2 October 2017

Detection of oxaliplatin-induced DNA crosslinks in vitro and in cancer patients using the alkaline comet assay.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2077023

2 October 2017

DNA interstrand crosslinks: natural and drug-induced DNA adducts that induce unique cellular responses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2077023

2 October 2017

Ataxia telangiectasia mutated (ATM) and ATM and Rad3-related protein exhibit selective target specificities in response to different forms of DNA damage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2077023

2 October 2017

Requirement of the MRN complex for ATM activation by DNA damage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2077023

2 October 2017

ATM and related protein kinases: safeguarding genome integrity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2077023

2 October 2017

Oxidative Strand Scission of Nucleic Acids: Routes Initiated by Hydrogen Abstraction from the Sugar Moiety

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2077023

2 October 2017

Cell cycle checkpoint signaling through the ATM and ATR kinases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2077023

2 October 2017

Single cell gel/comet assay: guidelines for in vitro and in vivo genetic toxicology testing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2077023

2 October 2017

A role for ATR in the DNA damage-induced phosphorylation of p53

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2077023

2 October 2017

DNA damage and mutagenesis by radiomimetic DNA-cleaving agents: bleomycin, neocarzinostatin and other enediynes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2077023

2 October 2017

Effects of the DNA-damaging enediyne C-1027 on intracellular SV40 and genomic DNA in green monkey kidney BSC-1 cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2077023

2 October 2017

Effects of bizelesin (U-77779), a bifunctional alkylating minor groove agent, on genomic and simian virus 40 DNA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2077023

2 October 2017

The yield of DNA double-strand breaks produced intracellularly by ionizing radiation: a review

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2077023

2 October 2017

Measurement of bleomycin, neocarzinostatin, and auromomycin cleavage of cell-free and intracellular simian virus 40 DNA and chromatin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2077023

2 July 2018

The ATM-mediated DNA-damage response: taking shape.

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0708274104

21 January 2018

Cellular responses to the DNA strand-scission enediyne C-1027 can be independent of ATM, ATR, and DNA-PK kinases

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0708274104

21 January 2018

Biosynthesis of the beta-amino acid moiety of the enediyne antitumor antibiotic C-1027 featuring beta-amino acyl-S-carrier protein intermediates

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0708274104

21 January 2018

Molecular mechanism of novel DNA sugar damage by an antitumour protein antibiotic

1 reference

https://pubmed.ncbi.nlm.nih.gov/17978180

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of ataxia telangiectasia mutated by DNA strand break-inducing agents correlates closely with the number of DNA double strand breaks

1 reference

https://pubmed.ncbi.nlm.nih.gov/17978180

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biosynthesis of the enediyne antitumor antibiotic C-1027

1 reference

https://pubmed.ncbi.nlm.nih.gov/17978180

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanism of Formation of Novel Covalent Drug·DNA Interstrand Cross-Links and Monoadducts by Enediyne Antitumor Antibiotics

1 reference

https://pubmed.ncbi.nlm.nih.gov/17978180

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1073/PNAS.0708274104

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

2007PNAS..10417632K

0 references

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

ResearchGate publication ID

0 references

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