The de novo and salvage pathways of GDP-mannose biosynthesis are both sufficient for the growth of bloodstream-form Trypanosoma brucei. (Q36141595)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22375793%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

title

The de novo and salvage pathways of GDP-mannose biosynthesis are both sufficient for the growth of bloodstream-form Trypanosoma brucei (English)

1 reference

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24 January 2020

main subject

Trypanosoma brucei

0 references

phosphomannose isomerase

1 reference

6 February 2019

6

1 reference

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24 January 2020

author name string

Sabine Kuettel

1

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24 January 2020

Majken C T Wadum

2

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24 January 2020

Maria Lucia S Güther

3

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24 January 2020

Karina Mariño

4

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24 January 2020

Carolin Riemer

5

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24 January 2020

language of work or name

English

0 references

publication date

21 March 2012

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24 January 2020

published in

Molecular Microbiology

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24 January 2020

volume

84

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24 January 2020

issue

2

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24 January 2020

page(s)

340-351

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The synthesis of UDP-N-acetylglucosamine is essential for bloodstream form trypanosoma brucei in vitro and in vivo and UDP-N-acetylglucosamine starvation reveals a hierarchy in parasite protein glycosylation.

24 January 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3412276

Deletion of the TbALG3 gene demonstrates site-specific N-glycosylation and N-glycan processing in Trypanosoma brucei

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3412276

Sugar nucleotide pools of Trypanosoma brucei, Trypanosoma cruzi, and Leishmania major

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3412276

Galactose starvation in a bloodstream form Trypanosoma brucei UDP-glucose 4'-epimerase conditional null mutant

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3412276

The suppression of galactose metabolism in procylic form Trypanosoma brucei causes cessation of cell growth and alters procyclin glycoprotein structure and copy number.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3412276

Galactose metabolism is essential for the African sleeping sickness parasite Trypanosoma brucei

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3412276

Purification, cloning and characterization of a GPI inositol deacylase from Trypanosoma brucei

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3412276

Disruption of mannose activation in Leishmania mexicana: GDP-mannose pyrophosphorylase is required for virulence, but not for viability

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3412276

The transferrin receptor of Trypanosoma brucei

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3412276

A tightly regulated inducible expression system for conditional gene knock-outs and dominant-negative genetics in Trypanosoma brucei

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3412276

The Alamar Blue assay to determine drug sensitivity of African trypanosomes (T.b. rhodesiense and T.b. gambiense) in vitro

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3412276

Oral ingestion of mannose elevates blood mannose levels: a first step toward a potential therapy for carbohydrate-deficient glycoprotein syndrome type I.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3412276

Trypanosoma brucei brucei: inhibition of glycosylation of the major variable surface coat glycoprotein by tunicamycin

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3412276

Phenylmethanesulphonyl fluoride inhibits GPI anchor biosynthesis in the African trypanosome

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3412276

The LAMP-like protein p67 plays an essential role in the lysosome of African trypanosomes

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3412276

Continuous cultivation of Trypanosoma brucei blood stream forms in a medium containing a low concentration of serum protein without feeder cell layers

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3412276

Comparative proteomics of glycosomes from bloodstream form and procyclic culture form Trypanosoma brucei brucei.

2 July 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2958.2012.08026.X

Properties of GDP-mannose pyrophosphorylase, a critical enzyme and drug target in Leishmania mexicana

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2958.2012.08026.X

GDP-mannose pyrophosphorylase is essential in the bloodstream form of Trypanosoma brucei

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2958.2012.08026.X

The membrane-bound histidine acid phosphatase TbMBAP1 is essential for endocytosis and membrane recycling in Trypanosoma brucei

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2958.2012.08026.X

The role of phosphomannose isomerase in Leishmania mexicana glycoconjugate synthesis and virulence

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2958.2012.08026.X

A comparative study of methylglyoxal metabolism in trypanosomatids

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2958.2012.08026.X

The suppression of galactose metabolism in Trypanosoma cruzi epimastigotes causes changes in cell surface molecular architecture and cell morphology.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2958.2012.08026.X

Characterization, localization, essentiality, and high-resolution crystal structure of glucosamine 6-phosphate N-acetyltransferase from Trypanosoma brucei.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2958.2012.08026.X

The glycosylation of the variant surface glycoproteins and procyclic acidic repetitive proteins of Trypanosoma brucei.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2958.2012.08026.X

Role of hexosamine biosynthesis in Leishmania growth and virulence

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2958.2012.08026.X

A model for sedimentation in inhomogeneous media. I. Dynamic density gradients from sedimenting co-solutes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2958.2012.08026.X

The de novo synthesis of GDP-fucose is essential for flagellar adhesion and cell growth in Trypanosoma brucei

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2958.2012.08026.X

Biosynthesis of Trypanosoma brucei variant surface glycoproteins. N-glycosylation and addition of a phosphatidylinositol membrane anchor.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3412276

In silico prediction of the glycosomal enzymes of Leishmania major and trypanosomes

23 September 2018

2 references

https://api.crossref.org/works/10.1111%2FJ.1365-2958.2012.08026.X

21 January 2018

12 December 2020

Developmentally regulated trafficking of the lysosomal membrane protein p67 in Trypanosoma brucei

1 reference

PubMed

12 December 2020

Candidate glycophospholipid precursor for the glycosylphosphatidylinositol membrane anchor of Trypanosoma brucei variant surface glycoproteins

1 reference

PubMed

12 December 2020

The mevalonate pathway in the bloodstream form of Trypanosoma brucei. Identification of dolichols containing 11 and 12 isoprene residues

1 reference

PubMed

12 December 2020

10.1111/J.1365-2958.2012.08026.X

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22375793%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

1 reference

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24 January 2020

PubMed publication ID

22375793

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22375793%20AND%20SRC:MED&resulttype=core&format=json