Pharmacological preconditioning with sildenafil: Basic mechanisms and clinical implications (Q36142633)

12 August 2017

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title

Pharmacological preconditioning with sildenafil: Basic mechanisms and clinical implications (English)

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12 August 2017

Rakesh C Kukreja

1

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12 August 2017

Fadi Salloum

2

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12 August 2017

Anindita Das

3

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12 August 2017

Ramzi Ockaili

4

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12 August 2017

Chang Yin

5

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12 August 2017

Yvonne A Bremer

6

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12 August 2017

Patrick W Fisher

7

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12 August 2017

Michael Wittkamp

8

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12 August 2017

John Hawkins

9

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12 August 2017

Eric Chou

10

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12 August 2017

Amit K Kukreja

11

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12 August 2017

Xiaoyin Wang

12

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12 August 2017

Vijay R Marwaha

13

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12 August 2017

Lei Xi

14

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12 August 2017

29 March 2005

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12 August 2017

Vascular Pharmacology

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12 August 2017

42

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12 August 2017

219-232

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12 August 2017

5-6

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Oxidative damage of cardiomyocytes is limited by extracellular regulated kinases 1/2-mediated induction of cyclooxygenase-2

12 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2005.02.010

Role of nitric oxide synthases in the infarct size-reducing effect conferred by heat stress in isolated rat hearts

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2005.02.010

Ischemic preconditioning depends on interaction between mitochondrial KATP channels and actin cytoskeleton.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2005.02.010

Protein kinases and kinase-modulated effectors in the late phase of ischemic preconditioning

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2005.02.010

Preconditioning against myocardial dysfunction after ischemia and reperfusion by an alpha 1-adrenergic mechanism

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2005.02.010

Time course of delayed myocardial protection after transient adenosine A1-receptor activation in the rabbit

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2005.02.010

Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2005.02.010

Immediate and Long-term Hemodynamic and Clinical Effects of Sildenafil in Patients With Pulmonary Arterial Hypertension Receiving Vasodilator Therapy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2005.02.010

The late phase of preconditioning

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2005.02.010

Sildenafil citrate (viagra) induces cardioprotective effects after ischemia/reperfusion injury in infant rabbits

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2005.02.010

Role of bradykinin in cardiac functional protection after global ischemia-reperfusion in rat heart

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2005.02.010

Chronic inhibition of nitric oxide production accelerates neointima formation and impairs endothelial function in hypercholesterolemic rabbits

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2005.02.010

ACC/AHA expert consensus document. Use of sildenafil (Viagra) in patients with cardiovascular disease. American College of Cardiology/American Heart Association

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2005.02.010

Effect of PDE5 inhibition on coronary hemodynamics in pacing-induced heart failure

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2005.02.010

Phosphodiesterase type 5 as a pharmacologic target in erectile dysfunction

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2005.02.010

Protein kinase C plays an essential role in sildenafil-induced cardioprotection in rabbits

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2005.02.010

Phosphodiesterase-5 inhibitor sildenafil preconditions adult cardiac myocytes against necrosis and apoptosis. Essential role of nitric oxide signaling.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2005.02.010

Opioid-induced second window of cardioprotection: potential role of mitochondrial KATP channels

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2005.02.010

Allosteric sites of phosphodiesterase-5 (PDE5). A potential role in negative feedback regulation of cGMP signaling in corpus cavernosum

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2005.02.010

The role of mitochondrial KATP channels in cardioprotection

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2005.02.010

The late phase of ischemic preconditioning is abrogated by targeted disruption of the inducible NO synthase gene

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2005.02.010

The effect of sildenafil on human vascular function, platelet activation, and myocardial ischemia

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2005.02.010

ATP-sensitive K(+) channel activation by nitric oxide and protein kinase G in rabbit ventricular myocytes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2005.02.010

Pharmacological evidence that inducible nitric oxide synthase is a mediator of delayed preconditioning.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2005.02.010

Acute type 5 phosphodiesterase inhibition with sildenafil enhances flow-mediated vasodilation in patients with chronic heart failure

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2005.02.010

Ischemic preconditioning upregulates vascular endothelial growth factor mRNA expression and neovascularization via nuclear translocation of protein kinase C epsilon in the rat ischemic myocardium

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2005.02.010

Cardiovascular effects of sildenafil citrate and recommendations for its use.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2005.02.010

Role of cyclic guanosine monophosphate in late preconditioning in conscious rabbits

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2005.02.010

Bradykinin B2 receptor is involved in the late phase of preconditioning in rabbit heart

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2005.02.010

Adenosine A(1) receptor mediates late preconditioning via activation of PKC-delta signaling pathway

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2005.02.010

Sildenafil-induced cardioprotection in rabbits.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2005.02.010

Cardioprotection with phosphodiesterase-5 inhibition--a novel preconditioning strategy.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2005.02.010

Delayed effects of sublethal ischemia on the acquisition of tolerance to ischemia

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2005.02.010

Cyclic GMP regulates the Ca-channel current in guinea pig ventricular myocytes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2005.02.010

Protection against infarction afforded by preconditioning is mediated by A1 adenosine receptors in rabbit heart.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2005.02.010

Evidence that translocation of protein kinase C is a key event during ischemic preconditioning of rabbit myocardium

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2005.02.010

Cardiac stress protein elevation 24 hours after brief ischemia or heat stress is associated with resistance to myocardial infarction

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2005.02.010

Ischemic preconditioning triggers the activation of MAP kinases and MAPKAP kinase 2 in rat hearts

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2005.02.010

Preconditioning of isolated rat heart is mediated by protein kinase C

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2005.02.010

Localization of protein kinases by anchoring proteins: a theme in signal transduction

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2005.02.010

Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2005.02.010

Sildenafil (Viagra) reduces arrhythmia severity during ischaemia 24 h after oral administration in dogs

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2005.02.010

Opening of mitochondrial KATP channel induces early and delayed cardioprotective effect: role of nitric oxide

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2005.02.010

Sildenafil (Viagra) induces powerful cardioprotective effect via opening of mitochondrial K(ATP) channels in rabbits

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2005.02.010

Opening of mitochondrial K(ATP) channel occurs downstream of PKC-epsilon activation in the mechanism of preconditioning

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2005.02.010

Myocardial preconditioning: basic concepts and potential mechanisms.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2005.02.010

Bradykinin as an endogenous myocardial protective substance with particular reference to ischemic preconditioning--a brief review of the evidence

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2005.02.010

Role of p38 mitogen-activated protein kinases in preconditioning: a detrimental factor or a protective kinase?

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2005.02.010

Ischemic Preconditioning Induces Selective Translocation of Protein Kinase C Isoforms and in the Heart of Conscious Rabbits Without Subcellular Redistribution of Total Protein Kinase C Activity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2005.02.010

The efficacy and tolerability of vardenafil, a new, oral, selective phosphodiesterase type 5 inhibitor, in patients with erectile dysfunction: the first at-home clinical trial

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2005.02.010

Sustained activation of p42/p44 mitogen-activated protein kinase during recovery from simulated ischaemia mediates adaptive cytoprotection in cardiomyocytes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2005.02.010

Cellular redistribution of inducible Hsp70 protein in the human and rabbit heart in response to the stress of chronic hypoxia: role of protein kinases,.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2005.02.010

Nitric oxide-induced cardioprotection in cultured rat ventricular myocytes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2005.02.010

Effects of sildenafil on myocardial infarct size, microvascular function, and acute ischemic left ventricular dilation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2005.02.010

Myocardial and coronary endothelial protective effects of acetylcholine after myocardial ischaemia and reperfusion in rats: role of nitric oxide

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2005.02.010

Phosphodiesterase 5 inhibitors: current status and potential applications

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2005.02.010

The phosphodiesterase inhibitory selectivity and the in vitro and in vivo potency of the new PDE5 inhibitor vardenafil

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2005.02.010

Sildenafil induces delayed preconditioning through inducible nitric oxide synthase-dependent pathway in mouse heart.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2005.02.010

Activation of mitochondrial ATP-dependent potassium channels by nitric oxide.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2005.02.010

Ischemic preconditioning in the intact rat heart is mediated by delta1- but not mu- or kappa-opioid receptors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2005.02.010

Intravenous sildenafil is a potent pulmonary vasodilator in children with congenital heart disease

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2005.02.010

Phosphodiesterase type 5 as a target for the treatment of hypoxia-induced pulmonary hypertension

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2005.02.010

Cardiac phosphodiesterase 5 (cGMP-specific) modulates beta-adrenergic signaling in vivo and is down-regulated in heart failure

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2005.02.010

Modulation of myocardial contraction by endocardial and coronary vascular endothelium

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2005.02.010

Cardiovascular events in users of sildenafil: results from first phase of prescription event monitoring in England

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2005.02.010

Long-term treatment with oral sildenafil in addition to continuous IV epoprostenol in patients with pulmonary arterial hypertension

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2005.02.010

Nitric oxide donors induce late preconditioning against myocardial stunning and infarction in conscious rabbits via an antioxidant-sensitive mechanism

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2005.02.010

Activation of mitochondrial K(ATP) channel elicits late preconditioning against myocardial infarction via protein kinase C signaling pathway

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2005.02.010

Alpha-adrenergic receptor stimulation produces late preconditioning through inducible nitric oxide synthase in mouse heart

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2005.02.010

Oxygen radicals can induce preconditioning in rabbit hearts

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2005.02.010

Differential effect of ischemic and pharmacological preconditioning on PKC isoform translocation in adult rat cardiac myocytes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2005.02.010

Adenosine in myocardial protection in on-pump and off-pump cardiac surgery

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2005.02.010

Tissue distribution of phosphodiesterase families and the effects of sildenafil on tissue cyclic nucleotides, platelet function, and the contractile responses of trabeculae carneae and aortic rings in vitro

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2005.02.010

Mitochondrial K(ATP) channel as an end effector of cardioprotection during late preconditioning: triggering role of nitric oxide

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2005.02.010

Ischemic preconditioning upregulates inducible nitric oxide synthase in cardiac myocyte

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2005.02.010

Opening of Ca2+-activated K+ channels triggers early and delayed preconditioning against I/R injury independent of NOS in mice.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2005.02.010

Interaction between cyclic adenosine monophosphate and cyclic gunaosine monophosphate in guinea pig ventricular myocardium

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2005.02.010

Effect of inhaled iloprost plus oral sildenafil in patients with primary pulmonary hypertension

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2005.02.010

Essential role of inducible nitric oxide synthase in monophosphoryl lipid A-induced late cardioprotection: evidence from pharmacological inhibition and gene knockout mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2005.02.010

Glycolipid RC-552 induces delayed preconditioning-like effect via iNOS-dependent pathway in mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2005.02.010

Evidence that NOS2 acts as a trigger and mediator of late preconditioning induced by acute systemic hypoxia.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2005.02.010

Cobalt chloride induces delayed cardiac preconditioning in mice through selective activation of HIF-1alpha and AP-1 and iNOS signaling.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2005.02.010

Cytoprotective role of Ca2+- activated K+ channels in the cardiac inner mitochondrial membrane

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2005.02.010

Ischaemic preconditioning: present position and future directions.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2005.02.010

Preconditioning protects ischemic rabbit heart by protein kinase C activation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2005.02.010

Sildenafil (Viagra) induces neurogenesis and promotes functional recovery after stroke in rats

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2005.02.010

Late preconditioning elicited by activation of adenosine A(3) receptor in heart: role of NF- kappa B, iNOS and mitochondrial K(ATP) channel

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2005.02.010

Protein kinase C-delta mediates adenosine A3 receptor-induced delayed cardioprotection in mouse

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2005.02.010

Role of inducible nitric oxide synthase in pharmacological "preconditioning" with monophosphoryl lipid A

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2005.02.010

Inducible nitric oxide synthase mediates delayed myocardial protection induced by activation of adenosine A(1) receptors: evidence from gene-knockout mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2005.02.010

p38 Triggers late preconditioning elicited by anisomycin in heart: involvement of NF-kappaB and iNOS.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2005.02.010

Delayed preconditioning with adenosine is mediated by opening of ATP-sensitive K(+) channels in rabbit heart

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2005.02.010

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7 January 2021

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Identifiers

DOI

10.1016/J.VPH.2005.02.010

1 reference

12 August 2017

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