MHC class Ib molecules bridge innate and acquired immunity (Q36146918)

12 August 2017

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title

MHC class Ib molecules bridge innate and acquired immunity (English)

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MHC class II protein complex

12 August 2017

main subject

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MHC class Ib protein complex

GO:0042613

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antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway

GO:0032398

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antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-independent

GO:0002488

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antigen processing and presentation, exogenous lipid antigen via MHC class Ib

GO:0042611

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antigen processing and presentation of exogenous antigen

GO:0048007

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antigen processing and presentation of endogenous antigen

GO:0019884

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GO:0019883

lipid antigen transport

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MHC protein complex assembly

GO:0002494

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lipid antigen assembly with MHC class Ib protein complex

GO:0002396

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antigen processing and presentation

GO:0002493

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antigen processing and presentation of peptide antigen via MHC class Ib

GO:0019882

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peptide antigen assembly with MHC class Ib protein complex

GO:0002428

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antigen processing and presentation of exogenous peptide antigen via MHC class Ib

GO:0002492

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antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent

GO:0002477

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antigen processing and presentation, endogenous lipid antigen via MHC class Ib

GO:0002481

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MHC class Ib protein complex assembly

GO:0048006

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antigen processing and presentation via MHC class Ib

GO:0002398

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antigen processing and presentation of endogenous peptide antigen via MHC class Ib

GO:0002475

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antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-independent

GO:0002476

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antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent

GO:0002482

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antigen processing and presentation of lipid antigen via MHC class Ib

GO:0002489

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John R Rodgers

1

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12 August 2017

Richard G Cook

series ordinal

2

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12 August 2017

publication date

1 June 2005

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Nature Reviews Immunology

12 August 2017

published in

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12 August 2017

volume

5

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12 August 2017

issue

6

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12 August 2017

page(s)

459-471

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Antigen presentation by major histocompatibility complex class I-B molecules

12 August 2017

cites work

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Qa-1 restriction of CD8+ suppressor T cells

31 March 2020

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An affinity/avidity model of peripheral T cell regulation

31 March 2020

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CD1: antigen presentation and T cell function

31 March 2020

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Biochemical features of the MHC-related protein 1 consistent with an immunological function

31 March 2020

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Association of MR1 protein, an MHC class I-related molecule, with beta(2)-microglobulin

31 March 2020

1 reference

Multifaceted roles of MHC class I and MHC class I–like molecules in T cell activation

31 March 2020

1 reference

Comparative genomics of the Mill family: a rapidly evolving MHC class I gene family

31 March 2020

1 reference

The innate immune response to tumors and its role in the induction of T-cell immunity

31 March 2020

1 reference

Hyperconservation of the N-formyl peptide binding site of M3: evidence that M3 is an old eutherian molecule with conserved recognition of a pathogen-associated molecular pattern

31 March 2020

1 reference

HLA-E allelic variants. Correlating differential expression, peptide affinities, crystal structures, and thermal stabilities

31 March 2020

1 reference

Qa-1, a nonclassical class I histocompatibility molecule with roles in innate and adaptive immunity

31 March 2020

1 reference

Crystal Structure of a T Cell Receptor Ligand T22: A Truncated MHC-Like Fold

31 March 2020

1 reference

The crystal structure of a TL/CD8alphaalpha complex at 2.1 A resolution: implications for modulation of T cell activation and memory

31 March 2020

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Functional expression of murine V2R pheromone receptors involves selective association with the M10 and M1 families of MHC class Ib molecules

31 March 2020

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Decoding the patterns of self and nonself by the innate immune system

31 March 2020

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Evidence that HLA-G is the functional homolog of mouse Qa-2, the ped gene product

31 March 2020

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Monocyte-derived HLA-G acts as a strong inhibitor of autologous CD4 T cell activation and is upregulated by interferon-beta in vitro and in vivo: rationale for the therapy of multiple sclerosis.

31 March 2020

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HLA-G1-expressing antigen-presenting cells induce immunosuppressive CD4+ T cells

31 March 2020

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The murine liver-specific nonclassical MHC class I molecule Q10 binds a classical peptide repertoire

31 March 2020

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Peptide presentation and NK inhibition by HLA-G.

31 March 2020

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Promiscuous antigen presentation by the nonclassical MHC Ib Qa-2 is enabled by a shallow, hydrophobic groove and self-stabilized peptide conformation

31 March 2020

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Crystal structure of HLA-G: a nonclassical MHC class I molecule expressed at the fetal-maternal interface

31 March 2020

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HLA-F Surface Expression on B Cell and Monocyte Cell Lines Is Partially Independent from Tapasin and Completely Independent from TAP

31 March 2020

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Protein expression and peptide binding suggest unique and interacting functional roles for HLA-E, F, and G in maternal-placental immune recognition

31 March 2020

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Capacity of myeloid and plasmacytoid dendritic cells especially at mature stage to express and secrete HLA-G molecules.

31 March 2020

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Alloreactive CD4+ and CD8+ T cells express the immunotolerant HLA-G molecule in mixed lymphocyte reactions: in vivo implications in transplanted patients

31 March 2020

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A new major histocompatibility complex class I b gene expressed in the mouse blastocyst and placenta

31 March 2020

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Secretion of human leukocyte antigen-G by human embryos is associated with a higher in vitro fertilization pregnancy rate

31 March 2020

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Fine mapping and positional candidate studies identify HLA-G as an asthma susceptibility gene on chromosome 6p21

31 March 2020

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Maturation of antigen-presenting cells is compromised in HLA-G transgenic mice

31 March 2020

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Presentation of peptide antigens by mouse CD1 requires endosomal localization and protein antigen processing

31 March 2020

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Positive selection of MHC class Ib-restricted CD8(+) T cells on hematopoietic cells

31 March 2020

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Class Ia MHC-deficient BALB/c mice generate CD8+ T cell-mediated protective immunity against Listeria monocytogenes infection

31 March 2020

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CD8+ T cells accumulate in the lungs of Mycobacterium tuberculosis-infected Kb-/-Db-/- mice, but provide minimal protection

31 March 2020

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Nonclassical binding of formylated peptide in crystal structure of the MHC class lb molecule H2-M3

31 March 2020

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H-2M3a violates the paradigm for major histocompatibility complex class I peptide binding.

31 March 2020

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Characterization of a human peptide deformylase: implications for antibacterial drug design

31 March 2020

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Exogenous peptides enter the endoplasmic reticulum of TAP-deficient cells and induce the maturation of nascent MHC class I molecules

31 March 2020

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The majority of H2-M3 is retained intracellularly in a peptide-receptive state and traffics to the cell surface in the presence of N-formylated peptides

31 March 2020

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Direct delivery of exogenous MHC class I molecule-binding oligopeptides to the endoplasmic reticulum of viable cells

31 March 2020

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Partially TAP-independent protection against Listeria monocytogenes by H2-M3-restricted CD8+ T cells

31 March 2020

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Tapasin enhances peptide-induced expression of H2-M3 molecules, but is not required for the retention of open conformers

31 March 2020

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Positive selection of thymocytes

31 March 2020

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A differential-avidity model for T-cell selection

31 March 2020

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The ligand for positive selection of T lymphocytes in the thymus

31 March 2020

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The selection of M3-restricted T cells is dependent on M3 expression and presentation of N-formylated peptides in the thymus

31 March 2020

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Positive selection of an H2-M3 restricted T cell receptor

31 March 2020

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A physiological ligand of positive selection is recognized as a weak agonist

31 March 2020

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A physiological ligand of positive selection is seen with high specificity

31 March 2020

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H2-M3-restricted T cells in bacterial infection: rapid primary but diminished memory responses

31 March 2020

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MHC class Ib-restricted CTL provide protection against primary and secondary Listeria monocytogenes infection

31 March 2020

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The Listeria monocytogenes lemA gene product is not required for intracellular infection or to activate fMIGWII-specific T cells

31 March 2020

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The role of dendritic cells in selection of classical and nonclassical CD8+ T cells in vivo

31 March 2020

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Positive selection of a Qa-1-restricted T cell receptor with specificity for insulin

31 March 2020

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Positive selection of mouse NK1+ T cells by CD1-expressing cortical thymocytes

31 March 2020

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CTL responses to H2-M3-restricted Listeria epitopes

31 March 2020

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A Listeria monocytogenes pentapeptide is presented to cytolytic T lymphocytes by the H2-M3 MHC class Ib molecule.

31 March 2020

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MHC class Ia-restricted memory T cells inhibit expansion of a nonprotective MHC class Ib (H2-M3)-restricted memory response.

31 March 2020

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Sequence convergence in the peptide-binding region of primate and rodent MHC class Ib molecules

31 March 2020

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Evolutionary relationships of major histocompatibility complex class I genes in simian primates

31 March 2020

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Polymorphism and conservation of the genes encoding Qa1 molecules

31 March 2020

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A ligand for the murine NK activation receptor Ly-49D: activation of tolerized NK cells from beta 2-microglobulin-deficient mice

31 March 2020

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HLA-E is expressed on trophoblast and interacts with CD94/NKG2 receptors on decidual NK cells

31 March 2020

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Blastocyst MHC, a putative murine homologue of HLA-G, protects TAP-deficient tumor cells from natural killer cell-mediated rejection in vivo

31 March 2020

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Peptide binding characteristics of the non-classical class Ib MHC molecule HLA-E assessed by a recombinant random peptide approach

31 March 2020

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Analysis of Qa-1(b) peptide binding specificity and the capacity of CD94/NKG2A to discriminate between Qa-1-peptide complexes

31 March 2020

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Analysis of HLA-E peptide-binding specificity and contact residues in bound peptide required for recognition by CD94/NKG2.

31 March 2020

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The human major histocompatibility complex class Ib molecule HLA-E binds signal sequence-derived peptides with primary anchor residues at positions 2 and 9

31 March 2020

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HLA-E-dependent presentation of Mtb-derived antigen to human CD8+ T cells

31 March 2020

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Identification of a human HLA-E-restricted CD8+ T cell subset in volunteers immunized with Salmonella enterica serovar Typhi strain Ty21a typhoid vaccine

31 March 2020

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HLA-E-restricted recognition of human cytomegalovirus by a subset of cytolytic T lymphocytes

31 March 2020

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Human T cell receptor-mediated recognition of HLA-E

31 March 2020

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Constitutive and regulated expression of the class IB molecule Qa-1 in pancreatic beta cells.

31 March 2020

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Identification of a tap-dependent leader peptide recognized by alloreactive T cells specific for a class Ib antigen

31 March 2020

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TAP- and tapasin-dependent HLA-E surface expression correlates with the binding of an MHC class I leader peptide

31 March 2020

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HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C

31 March 2020

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HLA-E is a major ligand for the natural killer inhibitory receptor CD94/NKG2A

31 March 2020

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Recognition of human histocompatibility leukocyte antigen (HLA)-E complexed with HLA class I signal sequence-derived peptides by CD94/NKG2 confers protection from natural killer cell-mediated lysis

31 March 2020

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Recognition of the class Ib molecule Qa-1(b) by putative activating receptors CD94/NKG2C and CD94/NKG2E on mouse natural killer cells

31 March 2020

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Implications of HLA-E allele expression and different HLA-E ligand diversity for the regulation of NK cells

31 March 2020

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HLA-E-bound peptides influence recognition by inhibitory and triggering CD94/NKG2 receptors: preferential response to an HLA-G-derived nonamer

31 March 2020

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Cutting edge: the human cytomegalovirus UL40 gene product contains a ligand for HLA-E and prevents NK cell-mediated lysis

31 March 2020

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Surface expression of HLA-E, an inhibitor of natural killer cells, enhanced by human cytomegalovirus gpUL40.

31 March 2020

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NK cell activity during human cytomegalovirus infection is dominated by US2-11-mediated HLA class I down-regulation

31 March 2020

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UL40-mediated NK evasion during productive infection with human cytomegalovirus.

31 March 2020

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Cytomegalovirus MHC class I homologues and natural killer cells: an overview

31 March 2020

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The HLA-A2 restricted T cell epitope HCV core 35-44 stabilizes HLA-E expression and inhibits cytolysis mediated by natural killer cells

31 March 2020

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HLA-A2 molecules in an antigen-processing mutant cell contain signal sequence-derived peptides

31 March 2020

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Intramembrane proteolysis of signal peptides: an essential step in the generation of HLA-E epitopes

31 March 2020

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Requirement of the proteasome for the trimming of signal peptide-derived epitopes presented by the nonclassical major histocompatibility complex class I molecule HLA-E

31 March 2020

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Requirements for signal peptide peptidase-catalyzed intramembrane proteolysis

31 March 2020

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Intramembrane-cleaving proteases: controlled liberation of proteins and bioactive peptides

31 March 2020

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A signal peptide peptidase (SPP) reporter activity assay based on the cleavage of type II membrane protein substrates provides further evidence for an inverted orientation of the SPP active site relative to presenilin

31 March 2020

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Factors controlling the trafficking and processing of a leader-derived peptide presented by Qa-1

31 March 2020

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The nonclassical MHC class I molecule Qa-1 forms unstable peptide complexes

31 March 2020

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Heat shock proteins can regulate expression of the Tla region-encoded class Ib molecule Qa-1.

31 March 2020

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Structural features impose tight peptide binding specificity in the nonclassical MHC molecule HLA-E

31 March 2020

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Population genetic studies of HLA-E: evidence for selection.

31 March 2020

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A peptide from heat shock protein 60 is the dominant peptide bound to Qa-1 in the absence of the MHC class Ia leader sequence peptide Qdm.

31 March 2020

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The 60-kDa heat shock protein modulates allograft rejection

31 March 2020

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A signal peptide derived from hsp60 binds HLA-E and interferes with CD94/NKG2A recognition

31 March 2020

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Molecular mimicry mediated by MHC class Ib molecules after infection with gram-negative pathogens

31 March 2020

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Gram-negative pathogens and molecular mimicry: is there a case for mistaken identity? Response

31 March 2020

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MHC-unrestricted recognition of bacteria-infected target cells by human CD8+ cytotoxic T lymphocytes

31 March 2020

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Functional analysis of the molecular factors controlling Qa1-mediated protection of target cells from NK lysis

31 March 2020

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Bacterial and host factors involved in the major histocompatibility complex class Ib-restricted presentation of Salmonella Hsp 60: novel pathway.

31 March 2020

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Heat shock protein 60 from Chlamydia pneumoniae elicits an unusual set of inflammatory responses via Toll-like receptor 2 and 4 in vivo

31 March 2020

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Cytokine function of heat shock proteins

31 March 2020

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Heat shock proteins 70 and 60 share common receptors which are expressed on human monocyte-derived but not epidermal dendritic cells

31 March 2020

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The receptor for heat shock protein 60 on macrophages is saturable, specific, and distinct from receptors for other heat shock proteins

31 March 2020

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Hydrophobicity: an ancient damage-associated molecular pattern that initiates innate immune responses.

31 March 2020

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31 March 2020

Reviving suppression?

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Murine CD8+ T cells that specifically delete autologous CD4+ T cells expressing V beta 8 TCR: a role of the Qa-1 molecule

31 March 2020

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Suppression of autoimmune disease after vaccination with autoreactive T cells that express Qa-1 peptide complexes

31 March 2020

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CD8+ T cells control the TH phenotype of MBP-reactive CD4+ T cells in EAE mice

31 March 2020

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Homeostatic control of immunity by TCR peptide-specific Tregs

31 March 2020

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Induction of TCR Vbeta-specific CD8+ CTLs by TCR Vbeta-derived peptides bound to HLA-E.

31 March 2020

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Analysis of regulatory CD8 T cells in Qa-1-deficient mice

31 March 2020

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Qa-1 restricted recognition of foreign antigen by a γδ T-cell hybridoma

31 March 2020

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Activation of murine epidermal V gamma 5/V delta 1-TCR(+) T cell lines by Glu-Tyr polypeptides

31 March 2020

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Response of murine gamma delta T cells to the synthetic polypeptide poly-Glu50Tyr50

31 March 2020

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Differential requirement for tapasin in the presentation of leader- and insulin-derived peptide antigens to Qa-1b-restricted CTLs

31 March 2020

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Homeostatic proliferation of a Qa-1b-restricted T cell: a distinction between the ligands required for positive selection and for proliferation in lymphopenic hosts

31 March 2020

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Immune recognition of a human renal cancer antigen through post-translational protein splicing.

31 March 2020

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An antigenic peptide produced by peptide splicing in the proteasome

31 March 2020

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Transporters associated with antigen processing (TAP)-independent presentation of soluble insulin to alpha/beta T cells by the class Ib gene product, Qa-1(b).

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRI1635

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12 August 2017

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