Anti-obesity efficacy of LH-21, a cannabinoid CB(1) receptor antagonist with poor brain penetration, in diet-induced obese rats (Q36147328)

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13 February 2020

title

Anti-obesity efficacy of LH-21, a cannabinoid CB(1) receptor antagonist with poor brain penetration, in diet-induced obese rats (English)

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13 February 2020

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13 February 2020

Nadine Jagerovic

6

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13 February 2020

Manuel Macias-Gonzalez

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Francisco-Javier Bermudez-Silva

13 February 2020

12

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13 February 2020

Juan Suarez

13

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13 February 2020

Francisco J. Pavon

15

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Fernando Rodríguez de Fonseca

13 February 2020

14

object named as

Fernando Rodríguez de Fonseca

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13 February 2020

4

Ana Crespillo

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13 February 2020

3

Margarita Vida

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13 February 2020

10

Juan Decara

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13 February 2020

8

Carmen Reyes-Cabello

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13 February 2020

author name string

Mónica Alonso

1

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13 February 2020

Laura Hernandez-Folgado

5

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13 February 2020

Pilar Goya

7

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13 February 2020

Vidal Perez-Valero

9

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13 February 2020

language of work or name

English

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publication date

1 April 2012

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British Journal of Pharmacology

13 February 2020

published in

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13 February 2020

volume

165

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13 February 2020

issue

7

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13 February 2020

page(s)

2274-2291

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Guide to Receptors and Channels (GRAC), 5th edition

13 February 2020

cites work

1 reference

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An overview of the metabolic effects of rimonabant in randomized controlled trials: potential for other cannabinoid 1 receptor blockers in obesity

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The neutral cannabinoid CB₁ receptor antagonist AM4113 regulates body weight through changes in energy intake in the rat.

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A novel peripherally restricted cannabinoid receptor antagonist, AM6545, reduces food intake and body weight, but does not cause malaise, in rodents

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The novel cannabinoid CB1 antagonist AM6545 suppresses food intake and food-reinforced behavior

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Peripheral CB1 cannabinoid receptor blockade improves cardiometabolic risk in mouse models of obesity

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GPR55 ligands promote receptor coupling to multiple signalling pathways

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CB1 antagonism exerts specific molecular effects on visceral and subcutaneous fat and reverses liver steatosis in diet-induced obese mice

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Responses to the cannabinoid receptor-1 antagonist, AM251, are more robust with age and with high-fat feeding

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Synthetic and plant-derived cannabinoid receptor antagonists show hypophagic properties in fasted and non-fasted mice

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2 October 2017

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The role of the endocannabinoid system in lipogenesis and fatty acid metabolism.

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The GPR55 ligand L-alpha-lysophosphatidylinositol promotes RhoA-dependent Ca2+ signaling and NFAT activation

2 October 2017

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Cannabinoid type 1 receptor: another arrow in the adipocytes' bow.

2 October 2017

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Central versus peripheral antagonism of cannabinoid CB1 receptor in obesity: effects of LH-21, a peripherally acting neutral cannabinoid receptor antagonist, in Zucker rats.

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2 October 2017

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Cannabinoid receptor signaling directly inhibits thermogenesis and alters expression of adiponectin and visfatin

2 October 2017

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2 October 2017

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2 October 2017

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In silico patent searching reveals a new cannabinoid receptor

2 October 2017

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2 October 2017

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Endocannabinoid activation at hepatic CB1 receptors stimulates fatty acid synthesis and contributes to diet-induced obesity

2 October 2017

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Effects of the cannabinoid-1 receptor blocker rimonabant on weight reduction and cardiovascular risk factors in overweight patients: 1-year experience from the RIO-Europe study

2 October 2017

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A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

2 October 2017

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2 October 2017

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2 October 2017

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The cannabinoid CB1 receptor antagonist SR141716 increases Acrp30 mRNA expression in adipose tissue of obese fa/fa rats and in cultured adipocyte cells

2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity

2 October 2017

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From lesions to leptin: hypothalamic control of food intake and body weight.

2 October 2017

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Arachidonic acid inhibits lipogenic gene expression in 3T3-L1 adipocytes through a prostanoid pathway

2 October 2017

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Positional cloning of the mouse obese gene and its human homologue

2 October 2017

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A Novel Serum Protein Similar to C1q, Produced Exclusively in Adipocytes

2 October 2017

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Synthesis and characterization of a peripherally restricted CB1 cannabinoid antagonist, URB447, that reduces feeding and body-weight gain in mice

2 October 2017

1 reference

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The novel cannabinoid CB1 receptor neutral antagonist AM4113 suppresses food intake and food-reinforced behavior but does not induce signs of nausea in rats

2 July 2018

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Leptin, leptin receptors, and the control of body weight.

2 July 2018

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AdipoQ is a novel adipose-specific gene dysregulated in obesity

2 July 2018

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Expression of the cannabinoid system in muscle: effects of a high-fat diet and CB1 receptor blockade

2 July 2018

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Basal and fasting/refeeding-regulated tissue levels of endogenous PPAR-alpha ligands in Zucker rats.

23 September 2018

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Antiobesity designed multiple ligands: Synthesis of pyrazole fatty acid amides and evaluation as hypophagic agents.

23 September 2018

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A novel pyrene-guanidiniocarbonyl-pyrrole cation efficiently differentiates between ds-DNA and ds-RNA by two independent, sensitive spectroscopic methods.

23 September 2018

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Pharmacological evaluation of LH-21, a newly discovered molecule that binds to cannabinoid CB1 receptor

23 September 2018

1 reference

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Endocannabinoid dysregulation in the pancreas and adipose tissue of mice fed with a high-fat diet

23 September 2018

1 reference

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A neutral CB1 receptor antagonist reduces weight gain in rat.

23 September 2018

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Analgesic properties of oleoylethanolamide (OEA) in visceral and inflammatory pain

23 September 2018

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The cannabinoid CB1 receptor inverse agonist, rimonabant, modifies body weight and adiponectin function in diet-induced obese rats as a consequence of reduced food intake

23 September 2018

1 reference

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Antiobesity effects of the novel in vivo neutral cannabinoid receptor antagonist 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-3-hexyl-1H-1,2,4-triazole--LH 21.

23 September 2018

1 reference

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Discovery of 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-3-hexyl-1h-1,2,4-triazole, a novel in vivo cannabinoid antagonist containing a 1,2,4-triazole motif

23 September 2018

1 reference

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Preferential effects of the cannabinoid CB1 receptor antagonist, SR 141716, on food intake and body weight gain of obese (fa/fa) compared to lean Zucker rats.

23 September 2018

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Antiobesity effects of chronic cannabinoid CB1 receptor antagonist treatment in diet-induced obese mice

23 September 2018

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A peripheral mechanism for CB1 cannabinoid receptor-dependent modulation of feeding.

23 September 2018

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Anti-obesity effect of SR141716, a CB1 receptor antagonist, in diet-induced obese mice

23 September 2018

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Increased hepatic lipogenesis but decreased expression of lipogenic gene in adipose tissue in human obesity

23 September 2018

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Appetite suppression and weight loss after the cannabinoid antagonist SR 141716.

23 September 2018

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Presence of the cannabinoid receptors, CB1 and CB2, in human omental and subcutaneous adipocytes

23 September 2018

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12 December 2020

Rimonabant reduces obesity-associated hepatic steatosis and features of metabolic syndrome in obese Zucker fa/fa rats

1 reference

12 December 2020

Inhibition of milk ingestion and growth after administration of a neutral cannabinoid CB1 receptor antagonist on the first postnatal day in the mouse

1 reference

12 December 2020

The endogenous cannabinoid system stimulates glucose uptake in human fat cells via phosphatidylinositol 3-kinase and calcium-dependent mechanisms

1 reference

12 December 2020

10.1111/J.1476-5381.2011.01698.X

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21951309%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21951309%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

PubMed publication ID

21951309

1 reference