Development of 2A peptide-based strategies in the design of multicistronic vectors (Q36150485)

12 August 2017

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title

Development of 2A peptide-based strategies in the design of multicistronic vectors (English)

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12 August 2017

Andrea L Szymczak

1

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PubMed ID

15934839

12 August 2017

Dario A A Vignali

series ordinal

2

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PubMed ID

15934839

12 August 2017

language of work or name

English

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publication date

1 May 2005

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Expert Opinion on Biological Therapy

12 August 2017

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12 August 2017

5

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12 August 2017

627-638

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12 August 2017

5

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Glioma cells transduced with an Escherichia coli CD/HSV-1 TK fusion gene exhibit enhanced metabolic suicide and radiosensitivity

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Construction and characterization of retroviral vectors expressing biologically active human interleukin-12.

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Viral vectors for gene transfer: a review of their use in the treatment of human diseases

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Viral vectors for gene therapy: the art of turning infectious agents into vehicles of therapeutics

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Development of herpes simplex virus replication-defective multigene vectors for combination gene therapy applications

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Polycistronic viral vectors

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Transcriptional control: an essential component of cancer gene therapy strategies?

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Comparison of promoter suppression in avian and murine retrovirus vectors

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Expression of Complete Chicken Thymidine Kinase Gene Inserted in a Retrovirus Vector

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Efficient retrovirus-mediated transfer and expression of a human adenosine deaminase gene in diploid skin fibroblasts from an adenosine deaminase-deficient human

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Transcriptional interference in avian retroviruses—implications for the promoter insertion model of leukaemogenesis

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Factors affecting long-term stability of Moloney murine leukemia virus-based vectors

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Factors affecting retroviral vector function and structural integrity

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cis-acting regulatory elements within gag genes of avian retroviruses

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High mutation rate of a spleen necrosis virus-based retrovirus vector

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A new set of positive/negative selectable markers for mammalian cells

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Limitations on the use of fused green fluorescent protein to investigate structure-function relationships for the cauliflower mosaic virus movement protein

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Fusagene vectors: a novel strategy for the expression of multiple genes from a single cistron.

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Internal initiation of translation of eukaryotic mRNA directed by a sequence derived from poliovirus RNA

21 January 2018

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Retroviral vectors containing putative internal ribosome entry sites: development of a polycistronic gene transfer system and applications to human gene therapy

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Internal ribosome entry sites in eukaryotic mRNA molecules

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Characterization of an internal ribosomal entry segment within the 5' leader of avian reticuloendotheliosis virus type A RNA and development of novel MLV-REV-based retroviral vectors

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The 5' untranslated region of Rhopalosiphum padi virus contains an internal ribosome entry site which functions efficiently in mammalian, plant, and insect translation systems.

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Polypurine (A)-rich sequences promote cross-kingdom conservation of internal ribosome entry

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The encephalomyocarditis virus internal ribosome entry site allows efficient coexpression of two genes from a recombinant provirus in cultured cells and in embryos

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Retroviral coexpression of a multidrug resistance gene (MDR1) and human alpha-galactosidase A for gene therapy of Fabry disease

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The internal ribosomal entry site of the encephalomyocarditis virus enables reliable coexpression of two transgenes in human primary T lymphocytes

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A retroviral vector that allows efficient co-expression of two genes and the versatility of alternate selection markers

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Internal ribosomal entry site-containing retroviral vectors with green fluorescent protein and drug resistance markers

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Stably transmitted triple-promoter retroviral vectors and their use in transformation of primary mammalian cells

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Generation of mammalian cells stably expressing multiple genes at predetermined levels.

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Use and comparison of different internal ribosomal entry sites (IRES) in tricistronic retroviral vectors

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Alternative ways to think about mRNA sequences and proteins that appear to promote internal initiation of translation

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Picornavirus internal ribosome entry segments: comparison of translation efficiency and the requirements for optimal internal initiation of translation in vitro

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Comparison of picornaviral IRES-driven internal initiation of translation in cultured cells of different origins.

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Recognition of picornavirus internal ribosome entry sites within cells; influence of cellular and viral proteins

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IRES-dependent second gene expression is significantly lower than cap-dependent first gene expression in a bicistronic vector

21 January 2018

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Improved vectors for stable expression of foreign genes in mammalian cells by use of the untranslated leader sequence from EMC virus

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Dicistronic transcription units for gene expression in mammalian cells

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Retrovector encoding a green fluorescent protein-herpes simplex virus thymidine kinase fusion protein serves as a versatile suicide/reporter for cell and gene therapy applications

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Composition and arrangement of genes define the strength of IRES-driven translation in bicistronic mRNAs

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Translation of the human c-myc P0 tricistronic mRNA involves two independent internal ribosome entry sites.

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A 9-nt segment of a cellular mRNA can function as an internal ribosome entry site (IRES) and when present in linked multiple copies greatly enhances IRES activity

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Development of multigene and regulated lentivirus vectors

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Identification of two short internal ribosome entry sites selected from libraries of random oligonucleotides

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Reconstitution of a metabolic pathway with triple-cistronic IRES-containing retroviral vectors for correction of tetrahydrobiopterin deficiency

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Construction and characterization of polycistronic retrovirus vectors for sustained and high-level co-expression of apolipoprotein A-I and lecithin-cholesterol acyltransferase

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Skipping the co-expression problem: the new 2A "CHYSEL" technology

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Cleavage of foot-and-mouth disease virus polyprotein is mediated by residues located within a 19 amino acid sequence

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The 'cleavage' activities of foot-and-mouth disease virus 2A site-directed mutants and naturally occurring '2A-like' sequences

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Retroviral vector-mediated expression of HoxB4 in hematopoietic cells using a novel coexpression strategy

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Recombinant AAV vectors containing the foot and mouth disease virus 2A sequence confer efficient bicistronic gene expression in cultured cells and rat substantia nigra neurons

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Tricistronic and tetracistronic retroviral vectors for gene transfer

21 January 2018

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Co-translational, intraribosomal cleavage of polypeptides by the foot-and-mouth disease virus 2A peptide

21 January 2018

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Stable, stoichiometric delivery of diverse protein functions

21 January 2018

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Use of the 2A sequence from foot-and-mouth disease virus in the generation of retroviral vectors for gene therapy

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Construction and characterization of pentacistronic retrovirus vectors

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The T cell antigen receptor: insights into organelle biology

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The majority of immunogenic epitopes generate CD4+ T cells that are dependent on MHC class II-bound peptide-flanking residues

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21 January 2018

Identifiers

DOI

10.1517/14712598.5.5.627

1 reference

12 August 2017

1 reference

PubMed ID

15934839