Selective PDE4 inhibitors as potent anti-inflammatory drugs for the treatment of airway diseases (Q36165890)

12 August 2017

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title

Selective PDE4 inhibitors as potent anti-inflammatory drugs for the treatment of airway diseases (English)

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12 August 2017

Vincent Lagente

1

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12 August 2017

Corinne Martin-Chouly

2

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12 August 2017

Elisabeth Boichot

3

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12 August 2017

Marco A Martins

4

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12 August 2017

Patrica M R Silva

5

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12 August 2017

publication date

1 March 2005

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Memórias do Instituto Oswaldo Cruz

12 August 2017

number of pages

6

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based on heuristic

inferred from page(s)

published in

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12 August 2017

volume

100 Suppl 1

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12 August 2017

page(s)

131-136

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Theophylline: new perspectives for an old drug

12 August 2017

cites work

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Characterization of five different proteins produced by alternatively spliced mRNAs from the human cAMP-specific phosphodiesterase PDE4D gene

21 January 2018

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Synthesis, structure-activity relationships, and pharmacological profile of 9-amino-4-oxo-1-phenyl-3,4,6,7-tetrahydro[1,4]diazepino[6, 7,1-hi]indoles: discovery of potent, selective phosphodiesterase type 4 inhibitors

21 January 2018

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Cilomilast, a selective phosphodiesterase-4 inhibitor for treatment of patients with chronic obstructive pulmonary disease: a randomised, dose-ranging study

21 January 2018

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The selective phosphodiesterase 4 inhibitor RP 73-401 reduced matrix metalloproteinase 9 activity and transforming growth factor-beta release during acute lung injury in mice: the role of the balance between Tumor necrosis factor-alpha and interleuk

21 January 2018

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Involvement of gelatinases (MMP-2 and MMP-9) in the development of airway inflammation and pulmonary fibrosis

21 January 2018

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Challenge of human Jurkat T-cells with the adenylate cyclase activator forskolin elicits major changes in cAMP phosphodiesterase (PDE) expression by up-regulating PDE3 and inducing PDE4D1 and PDE4D2 splice variants as well as down-regulating a novel

21 January 2018

1 reference

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Antiinflammatory effects of the phosphodiesterase-4 inhibitor cilomilast (Ariflo) in chronic obstructive pulmonary disease

21 January 2018

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Phosphodiesterase 4 inhibitors and the treatment of asthma: where are we now and where do we go from here?

21 January 2018

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Cilomilast: a second generation phosphodiesterase 4 inhibitor for asthma and chronic obstructive pulmonary disease

21 January 2018

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Effects of rolipram on cyclic AMP levels in alveolar macrophages and lipopolysaccharide-induced inflammation in mouse lung

21 January 2018

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Inhibition of antigen-induced pulmonary eosinophilia and neutrophilia by selective inhibitors of phosphodiesterase types 3 or 4 in Brown Norway rats

21 January 2018

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DMSO-treated HL60 cells: a model of neutrophil-like cells mainly expressing PDE4B subtype.

21 January 2018

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Role of PDE4 in superoxide anion generation through p44/42MAPK regulation: a cAMP and a PKA-independent mechanism.

21 January 2018

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Remodeling in asthma and chronic obstructive lung disease

21 January 2018

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Induction of the cyclic nucleotide phosphodiesterase PDE4B is essential for LPS-activated TNF-alpha responses

21 January 2018

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Subcellular localization of rolipram-sensitive, cAMP-specific phosphodiesterases. Differential targeting and activation of the splicing variants derived from the PDE4D gene

21 January 2018

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PDE4 inhibitors attenuate fibroblast chemotaxis and contraction of native collagen gels

21 January 2018

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Phosphodiesterase 4 inhibitor cilomilast inhibits fibroblast-mediated collagen gel degradation induced by tumor necrosis factor-alpha and neutrophil elastase

21 January 2018

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Effects of isozyme-selective phosphodiesterase inhibitors on eosinophil infiltration in the guinea-pig lung

21 January 2018

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Suppression of human inflammatory cell function by subtype-selective PDE4 inhibitors correlates with inhibition of PDE4A and PDE4B.

21 January 2018

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Modulation of matrix metalloproteinase production from human lung fibroblasts by type 4 phosphodiesterase inhibitors

21 January 2018

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Multiple splice variants of phosphodiesterase PDE4C cloned from human lung and testis

21 January 2018

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Deletion of phosphodiesterase 4D in mice shortens alpha(2)-adrenoceptor-mediated anesthesia, a behavioral correlate of emesis

21 January 2018

1 reference

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Differential regulation of metalloproteinase production, proliferation and chemotaxis of human lung fibroblasts by PDGF, interleukin-1beta and TNF-alpha

21 January 2018

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Modulation of eotaxin formation and eosinophil migration by selective inhibitors of phosphodiesterase type 4 isoenzyme

21 January 2018

1 reference

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Evidence that cyclic AMP phosphodiesterase inhibitors suppress TNF alpha generation from human monocytes by interacting with a 'low-affinity' phosphodiesterase 4 conformer

21 January 2018

1 reference

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Proposal for pharmacologically distinct conformers of PDE4 cyclic AMP phosphodiesterases

21 January 2018

1 reference

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10.1590/S0074-02762005000900023

21 January 2018

Identifiers

DOI

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12 August 2017

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