Reverse engineering a hierarchical regulatory network downstream of oncogenic KRAS. (Q36171170)

12 August 2017

Reverse engineering a hierarchical regulatory network downstream of oncogenic KRAS. (English)

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12 August 2017

8

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12 August 2017

Bertram Klinger

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Stefan Legewie

object named as

Stefan Legewie

2

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Hanspeter Herzel

7

object named as

Hanspeter Herzel

1 reference

12 August 2017

Iwona Stelniec-Klotz

1

1 reference

12 August 2017

Oleg Tchernitsa

3

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12 August 2017

Franziska Witzel

4

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12 August 2017

Christine Sers

6

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12 August 2017

Reinhold Schäfer

9

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12 August 2017

1 January 2012

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Molecular Systems Biology

12 August 2017

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12 August 2017

8

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12 August 2017

601

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describes a project that uses

12 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3421447/fullTextXML

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cites work

Strong negative feedback from Erk to Raf confers robustness to MAPK signalling.

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Potential therapeutic strategies to overcome acquired resistance to BRAF or MEK inhibitors in BRAF mutant cancers

1 October 2017

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Identification of Y-box binding protein 1 as a core regulator of MEK/ERK pathway-dependent gene signatures in colorectal cancer cells

1 October 2017

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EGF decreases the abundance of microRNAs that restrain oncogenic transcription factors

1 October 2017

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Requirement of the NF-kappaB subunit p65/RelA for K-Ras-induced lung tumorigenesis

1 October 2017

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The incoherent feedforward loop can provide fold-change detection in gene regulation

1 October 2017

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The transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line.

1 October 2017

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Distilling free-form natural laws from experimental data

1 October 2017

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HMGA2 maintains oncogenic RAS-induced epithelial-mesenchymal transition in human pancreatic cancer cells

1 October 2017

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A systems biological approach suggests that transcriptional feedback regulation by dual-specificity phosphatase 6 shapes extracellular signal-related kinase activity in RAS-transformed fibroblasts

1 October 2017

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Ras oncogenes: split personalities

1 October 2017

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Ras promotes growth by alternative splicing-mediated inactivation of the KLF6 tumor suppressor in hepatocellular carcinoma.

1 October 2017

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Recurrent design patterns in the feedback regulation of the mammalian signalling network

1 October 2017

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HMGA2 gene is a promising target for ovarian cancer silencing therapy

1 October 2017

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NF-kappa B genes have a major role in inflammatory breast cancer

1 October 2017

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The HMGA proteins: a myriad of functions (Review).

1 October 2017

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Deciphering AP-1 function in tumorigenesis: fra-ternizing on target promoters

1 October 2017

1 reference

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Fra-1 promotes growth and survival in RAS-transformed thyroid cells by controlling cyclin A transcription

1 October 2017

1 reference

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Growth factor-induced MAPK network topology shapes Erk response determining PC-12 cell fate

1 October 2017

1 reference

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Role of oncoprotein growth factor independent-1 (GFI1) in repression of 25-hydroxyvitamin D 1alpha-hydroxylase (CYP27B1): a comparative analysis in human prostate cancer and kidney cells

1 October 2017

1 reference

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Effects of Ras signaling on gene expression analyzed by customized microarrays

1 October 2017

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ARACNE: An Algorithm for the Reconstruction of Gene Regulatory Networks in a Mammalian Cellular Context

1 October 2017

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OTX1 and OTX2 expression correlates with the clinicopathologic classification of medulloblastomas

1 October 2017

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The Fos family of transcription factors and their role in tumourigenesis

1 October 2017

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Molecular mechanisms of drug resistance

1 October 2017

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A large-scale RNAi screen in human cells identifies new components of the p53 pathway

1 October 2017

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A resource for large-scale RNA-interference-based screens in mammals.

1 October 2017

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Inferring genetic networks and identifying compound mode of action via expression profiling

1 October 2017

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Accumulation of Fra-1 in ras-transformed cells depends on both transcriptional autoregulation and MEK-dependent posttranslational stabilization

1 October 2017

1 reference

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Untangling the wires: a strategy to trace functional interactions in signaling and gene networks

1 October 2017

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NF-kappaB in cancer: from innocent bystander to major culprit

1 October 2017

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Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

1 October 2017

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Global analysis of differential gene expression after transformation with the v-H-ras oncogene in a murine tumor model

1 October 2017

1 reference

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Distinct roles of Jun : Fos and Jun : ATF dimers in oncogenesis

1 October 2017

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Significance analysis of microarrays applied to the ionizing radiation response

1 October 2017

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Akt suppresses apoptosis by stimulating the transactivation potential of the RelA/p65 subunit of NF-kappaB.

1 October 2017

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A genome-wide survey of RAS transformation targets

1 October 2017

1 reference

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Emergent properties of networks of biological signaling pathways

1 October 2017

1 reference

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Neoplastic transformation of rat thyroid cells requires the junB and fra-1 gene induction which is dependent on the HMGI-C gene product

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3421447

The Gfi-1 proto-oncoprotein contains a novel transcriptional repressor domain, SNAG, and inhibits G1 arrest induced by interleukin-2 withdrawal

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3421447

Differential expression of two different homeobox gene families during mouse tegument morphogenesis

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3421447

A rapid, sensitive, and specific method for the determination of protein in dilute solution

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3421447

Gene network dynamics controlling keratinocyte migration

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3421447

Molecular interpretation of ERK signal duration by immediate early gene products

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3421447

Increase in AP-1 activity is a general event in thyroid cell transformation in vitro and in vivo

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3421447

Transformation by ras modifies AP1 composition and activity

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3421447

Transformation of cultured rat ovarian surface epithelial cells by Kirsten murine sarcoma virus

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3421447

A cell line, ROSE 199, derived from normal rat ovarian surface epithelium

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3421447

Sequential development of mutant clones in an imatinib resistant chronic myeloid leukaemia patient following sequential treatment with multiple tyrosine kinase inhibitors: an emerging problem?

2 July 2018

1 reference

https://api.crossref.org/works/10.1038%2FMSB.2012.32

Development and testing of a prototype reflex measurement system employing artificial neural networks

21 January 2018

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https://api.crossref.org/works/10.1038%2FMSB.2012.32

A yeast synthetic network for in vivo assessment of reverse-engineering and modeling approaches

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMSB.2012.32

Roles of KLF6 and KLF6-SV1 in ovarian cancer progression and intraperitoneal dissemination.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMSB.2012.32

Oncogenic Ha-Ras-induced signaling activates NF-kappaB transcriptional activity, which is required for cellular transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMSB.2012.32

Transcriptional basis of KRAS oncogene-mediated cellular transformation in ovarian epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMSB.2012.32

The Inferelator 2.0: a scalable framework for reconstruction of dynamic regulatory network models.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3421447

A Germline DNA Polymorphism Enhances Alternative Splicing of theKLF6Tumor Suppressor Gene and Is Associated with Increased Prostate Cancer Risk

23 September 2018

1 reference

https://api.crossref.org/works/10.1038%2FMSB.2012.32

21 January 2018

Identifiers

DOI

10.1038/MSB.2012.32

1 reference

12 August 2017

1 reference

12 August 2017

PubMed publication ID

22864383

1 reference