Mechanism of action of and mechanism of reduced susceptibility to the novel anti-Clostridium difficile compound LFF571 (Q36171778)

12 August 2017

Mechanism of action of and mechanism of reduced susceptibility to the novel anti-Clostridium difficile compound LFF571 (English)

1 reference

12 August 2017

Clostridium difficile

0 references

author name string

J A Leeds

1

1 reference

12 August 2017

M Sachdeva

2

1 reference

12 August 2017

S Mullin

3

1 reference

12 August 2017

J Dzink-Fox

4

1 reference

12 August 2017

M J Lamarche

5

1 reference

12 August 2017

language of work or name

English

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publication date

29 May 2012

1 reference

Antimicrobial Agents and Chemotherapy

12 August 2017

3

1 reference

based on heuristic

inferred from page(s)

published in

1 reference

12 August 2017

56

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12 August 2017

8

1 reference

12 August 2017

4463-4465

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Discovery of LFF571: an investigational agent for Clostridium difficile infection

12 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3421628

Comparative in vitro activities of LFF571 against Clostridium difficile and 630 other intestinal strains of aerobic and anaerobic bacteria

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3421628

In vitro and in vivo activities of novel, semisynthetic thiopeptide inhibitors of bacterial elongation factor Tu.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3421628

Clostridium difficile infection: An overview of the disease and its pathogenesis, epidemiology and interventions

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3421628

Fidaxomicin versus vancomycin for Clostridium difficile infection

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3421628

Clostridium difficile infection: epidemiology, risk factors and management

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3421628

Antibiotic treatment for Clostridium difficile-associated diarrhea in adults

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3421628

The chemical basis for the action of the vancomycin group of antibiotics

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3421628

Antibiotic GE2270 a: a novel inhibitor of bacterial protein synthesis. I. Isolation and characterization

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3421628

Efficacy of LFF571 in a hamster model of Clostridium difficile infection

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3421628

European Society of Clinical Microbiology and Infectious Diseases (ESCMID): treatment guidance document for Clostridium difficile infection (CDI).

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3421628

Spectrum of activity and mode of action of REP3123, a new antibiotic to treat Clostridium difficile infections.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3421628

Treatment of Clostridium difficile infection.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3421628

GE2270A-resistant mutations in elongation factor Tu allow productive aminoacyl-tRNA binding to EF-Tu.GTP.GE2270A complexes.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3421628

Structural Basis of the Action of Pulvomycin and GE2270 A on Elongation Factor Tu†,‡

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3421628

A defined growth medium for Clostridium difficile

5 December 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22644023

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1128/AAC.06354-11

1 reference

12 August 2017

1 reference

12 August 2017

1 reference