Passenger transgenes reveal intrinsic specificity of the antibody hypermutation mechanism: clustering, polarity, and specific hot spots (Q36172034)

12 August 2017

Passenger transgenes reveal intrinsic specificity of the antibody hypermutation mechanism: clustering, polarity, and specific hot spots (English)

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12 August 2017

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A G Betz

1

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12 August 2017

C Rada

2

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12 August 2017

R Pannell

3

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12 August 2017

C Milstein

4

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12 August 2017

M S Neuberger

5

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12 August 2017

language of work or name

English

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publication date

1 March 1993

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Proceedings of the National Academy of Sciences of the United States of America

12 August 2017

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12 August 2017

90

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12 August 2017

6

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12 August 2017

2385-2388

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Patterns of somatic mutations in immunoglobulin variable genes

12 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=46091

Mutation drift and repertoire shift in the maturation of the immune response

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=46091

Mutational hot spots in Ig V region genes of human follicular lymphomas

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=46091

Boundaries of somatic mutation in rearranged immunoglobulin genes: 5' boundary is near the promoter, and 3' boundary is approximately 1 kb from V(D)J gene

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=46091

Heterogeneity of DNA repair at the gene level

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=46091

Hierarchies of DNA repair in mammalian cells: biological consequences

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=46091

Somatic hypermutation of immunoglobulin kappa may depend on sequences 3' of C kappa and occurs on passenger transgenes.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=46091

Mutation and selection during the secondary response to 2-phenyloxazolone

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=46091

Mutation pattern of immunoglobulin transgenes is compatible with a model of somatic hypermutation in which targeting of the mutator is linked to the direction of DNA replication

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=46091

Clonal evolution of a follicular lymphoma: evidence for antigen selection

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=46091

The repertoire of human germline VH sequences reveals about fifty groups of VH segments with different hypervariable loops

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=46091

Antibody engineering for the analysis of affinity maturation of an anti-hapten response.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=46091

Activation of memory and virgin B cell clones in hyperimmune animals.

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=46091

Maintenance of B-cell memory by long-lived cells generated from proliferating precursors

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=46091

Distribution of mutations around rearranged heavy-chain antibody variable-region genes

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=46091

Colony assays for antibody fragments expressed in bacteria.

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=46091

Non-random features of the repertoire expressed by the members of one V kappa gene family and of the V-J recombination.

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=46091

Accumulation of somatic mutants in the B cell compartment after primary immunization with a T cell-dependent antigen

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=46091

Nonrandomness of point mutation as reflected in nucleotide substitutions in pseudogenes and its evolutionary implications

2 July 2018

1 reference

12 December 2020

Somatic mutation and the maturation of immune response to 2-phenyl oxazolone

1 reference

12 December 2020

Model for the interaction of DNA junctions and resolving enzymes

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12 December 2020

V gene rearrangement is required to fully activate the hypermutation mechanism in B cells

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12 December 2020

Origin of Antibody Variation

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12 December 2020

Identifiers

DOI

10.1073/PNAS.90.6.2385

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12 August 2017

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12 August 2017

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