Deficiency of PTP1B in leptin receptor-expressing neurons leads to decreased body weight and adiposity in mice. (Q36177418)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22802463%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

title

Deficiency of PTP1B in leptin receptor-expressing neurons leads to decreased body weight and adiposity in mice (English)

1 reference

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8 February 2020

4

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8 February 2020

author name string

Ryan C Tsou

series ordinal

1

1 reference

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8 February 2020

Derek J Zimmer

series ordinal

2

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8 February 2020

Bart C De Jonghe

series ordinal

3

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8 February 2020

language of work or name

English

0 references

publication date

16 July 2012

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8 February 2020

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8 February 2020

volume

153

1 reference

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8 February 2020

issue

9

1 reference

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8 February 2020

page(s)

4227-4237

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Adipocyte-specific protein tyrosine phosphatase 1B deletion increases lipogenesis, adipocyte cell size and is a minor regulator of glucose homeostasis

8 February 2020

cites work

1 reference

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Role of GABA release from leptin receptor-expressing neurons in body weight regulation

1 October 2017

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Intracerebroventricular leptin infusion improves glucose homeostasis in lean type 2 diabetic MKR mice via hepatic vagal and non-vagal mechanisms

1 October 2017

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Regulation of brown fat adipogenesis by protein tyrosine phosphatase 1B

1 October 2017

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Molecular mapping of mouse brain regions innervated by leptin receptor-expressing cells

1 October 2017

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Segregation of acute leptin and insulin effects in distinct populations of arcuate proopiomelanocortin neurons

1 October 2017

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PTP1B and SHP2 in POMC neurons reciprocally regulate energy balance in mice

1 October 2017

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Endogenous leptin signaling in the caudal nucleus tractus solitarius and area postrema is required for energy balance regulation

1 October 2017

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Chronic peroxisome proliferator-activated receptor gamma (PPARgamma) activation of epididymally derived white adipocyte cultures reveals a population of thermogenically competent, UCP1-containing adipocytes molecularly distinct from classic [...]

1 October 2017

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Deletion of protein tyrosine phosphatase 1b improves peripheral insulin resistance and vascular function in obese, leptin-resistant mice via reduced oxidant tone

1 October 2017

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Leptin targets in the mouse brain

1 October 2017

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Direct innervation of GnRH neurons by metabolic- and sexual odorant-sensing leptin receptor neurons in the hypothalamic ventral premammillary nucleus

1 October 2017

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Liver-specific deletion of protein-tyrosine phosphatase 1B (PTP1B) improves metabolic syndrome and attenuates diet-induced endoplasmic reticulum stress

1 October 2017

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Specific physiological roles for signal transducer and activator of transcription 3 in leptin receptor-expressing neurons

1 October 2017

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Improved glucose homeostasis in mice with muscle-specific deletion of protein-tyrosine phosphatase 1B.

1 October 2017

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Transcriptional control of brown fat determination by PRDM16

1 October 2017

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Hypothalamic leptin regulation of energy homeostasis and glucose metabolism

1 October 2017

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Mice lacking inhibitory leptin receptor signals are lean with normal endocrine function

1 October 2017

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1 October 2017

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PTP1B antisense oligonucleotide lowers PTP1B protein, normalizes blood glucose, and improves insulin sensitivity in diabetic mice

1 October 2017

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Interaction of protein tyrosine phosphatase (PTP) 1B with its substrates is influenced by two distinct binding domains

1 October 2017

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Attenuation of leptin action and regulation of obesity by protein tyrosine phosphatase 1B.

1 October 2017

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PTP1B regulates leptin signal transduction in vivo

1 October 2017

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Increased energy expenditure, decreased adiposity, and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1B-deficient mice

1 October 2017

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Tyrosine dephosphorylation and deactivation of insulin receptor substrate-1 by protein-tyrosine phosphatase 1B. Possible facilitation by the formation of a ternary complex with the Grb2 adaptor protein

1 October 2017

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Development changes in long-form leptin receptor expression and localization in rat brain

1 October 2017

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Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene

1 October 2017

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Distributions of leptin receptor mRNA isoforms in the rat brain

1 October 2017

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Localization of leptin receptor (Ob-R) messenger ribonucleic acid in the rodent hindbrain

1 October 2017

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Protein-tyrosine phosphatase 1B complexes with the insulin receptor in vivo and is tyrosine-phosphorylated in the presence of insulin

1 October 2017

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1 October 2017

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1 October 2017

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1 October 2017

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1 October 2017

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Osmotic loading of neutralizing antibodies demonstrates a role for protein-tyrosine phosphatase 1B in negative regulation of the insulin action pathway

1 October 2017

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Inhibition of hypothalamic neuropeptide Y gene expression by insulin

1 October 2017

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Chronic intracerebroventricular infusion of insulin reduces food intake and body weight of baboons

1 October 2017

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Medicine. Beige can be slimming

1 October 2017

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Beneficial effects of PTP1B deficiency on brown adipocyte differentiation and protection against apoptosis induced by pro- and anti-inflammatory stimuli.

2 July 2018

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Neuronal protein tyrosine phosphatase 1B deficiency results in inhibition of hypothalamic AMPK and isoform-specific activation of AMPK in peripheral tissues

2 July 2018

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Characterization of leptin-responsive neurons in the caudal brainstem.

2 July 2018

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2 July 2018

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23 September 2018

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23 September 2018

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23 September 2018

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23 September 2018

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23 September 2018

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23 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22802463

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Obesity epidemic in need of answers

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22802463

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Effect of intracerebroventricular insulin infusion on diabetic hyperphagia and hypothalamic neuropeptide gene expression

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22802463

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1210/EN.2012-1548

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22802463%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22802463%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22802463%20AND%20SRC:MED&resulttype=core&format=json