Molecular classification and pathogenesis of eosinophilic disorders: 2005 update (Q36182741)

12 August 2017

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title

Molecular classification and pathogenesis of eosinophilic disorders: 2005 update (English)

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12 August 2017

Jason Gotlib

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12 August 2017

1 January 2005

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12 August 2017

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12 August 2017

114

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12 August 2017

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12 August 2017

7-25

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Recent advances in pathogenesis and management of hypereosinophilic syndromes

12 August 2017

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Myelodysplastic syndrome with hypereosinophilia and a nonrandom chromosomal abnormality dic(1;7): confirmation of eosinophil clonal involvement by fluorescence in situ hybridization.

21 January 2018

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CHIC2 deletion, a surrogate for FIP1L1-PDGFRA fusion, occurs in systemic mastocytosis associated with eosinophilia and predicts response to imatinib mesylate therapy

21 January 2018

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Cytogenetic and molecular genetic aspects of eosinophilic leukaemias

21 January 2018

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A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome

21 January 2018

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Chronic eosinophilic leukemia with 46,XY,1,der(1;7)(q10;p10) translocation.

21 January 2018

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Heterogeneity of response to imatinib-mesylate (glivec) in patients with hypereosinophilic syndrome: implications for dosing and pathogenesis

21 January 2018

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Chronic myeloid leukemia associated hypereosinophilic syndrome with a clonal t(4;7)(q11;q32).

21 January 2018

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t(5;9)(q11;q34): a novel familial translocation involving Abelson oncogene and association with hypereosinophilia.

21 January 2018

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Chronic eosinophilic leukemia with t(6;11)(q27;q23) translocation

21 January 2018

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Clinical and molecular features of FIP1L1-PDFGRA (+) chronic eosinophilic leukemias.

21 January 2018

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Eosinophilia in myelodysplastic syndrome with a (12;21)(q23;q22) translocation

21 January 2018

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Successful treatment with imatinib mesylate of hypereosinophilic syndrome (chronic eosinophilic leukemia) with myelofibrosis

21 January 2018

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Hypereosinophilia associated with monosomy 7.

21 January 2018

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Imatinib therapy for hypereosinophilic syndrome and other eosinophilic disorders

21 January 2018

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Glycoprotein V: the predominant target antigen in gold-induced autoimmune thrombocytopenia

21 January 2018

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Hypereosinophilic syndrome in a child mosaic for a congenital triplication of the short arm of chromosome 8.

21 January 2018

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Chronic eosinophilic leukaemia (CEL): a distinct myeloproliferative disease.

21 January 2018

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Rapid reversion of Loeffler's endocarditis by imatinib in early stage clonal hypereosinophilic syndrome.

21 January 2018

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FIP1L1-PDGFRA fusion: prevalence and clinicopathologic correlates in 89 consecutive patients with moderate to severe eosinophilia

21 January 2018

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Eosinophilic Leukemia with Fibrosing Endocarditis and Short Y Chromosome

21 January 2018

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Chromosomal aneuploidy in a patient with hypereosinophilic syndrome. Evidence for a malignant disease

21 January 2018

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Imatinib-mesylate for all patients with hypereosinophilic syndrome?

21 January 2018

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A case of monosomy-7 eosinophilic leukemia and neurofibromatosis, terminated with disseminated cryptococcosis

21 January 2018

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Acute myelogenous leukemia with eosinophilic differentiation and trisomy-1.

21 January 2018

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Class III receptor tyrosine kinases: role in leukaemogenesis

21 January 2018

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Structure of the receptor for platelet-derived growth factor helps define a family of closely related growth factor receptors

21 January 2018

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PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor

21 January 2018

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PDGF-D is a specific, protease-activated ligand for the PDGF beta-receptor

21 January 2018

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PDGF-D, a new protease-activated growth factor

21 January 2018

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Activation of Stat5 by platelet-derived growth factor (PDGF) is dependent on phosphorylation sites in PDGF beta-receptor juxtamembrane and kinase insert domains

21 January 2018

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STAT activation by the PDGF receptor requires juxtamembrane phosphorylation sites but not Src tyrosine kinase activation

21 January 2018

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Fusion of PDGF receptor beta to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation

21 January 2018

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H4(D10S170), a gene frequently rearranged in papillary thyroid carcinoma, is fused to the platelet-derived growth factor receptor beta gene in atypical chronic myeloid leukemia with t(5;10)(q33;q22).

21 January 2018

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Rabaptin-5 is a novel fusion partner to platelet-derived growth factor beta receptor in chronic myelomonocytic leukemia.

21 January 2018

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Novel translocations that disrupt the platelet-derived growth factor receptor beta (PDGFRB) gene in BCR-ABL-negative chronic myeloproliferative disorders.

21 January 2018

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Cloning of the t(1;5)(q23;q33) in a myeloproliferative disorder associated with eosinophilia: involvement of PDGFRB and response to imatinib

21 January 2018

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Myeloproliferative disorders with translocations of chromosome 5q31-35: role of the platelet-derived growth factor receptor Beta

21 January 2018

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Transforming properties of the Huntingtin interacting protein 1/ platelet-derived growth factor beta receptor fusion protein.

21 January 2018

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The t(4;22)(q12;q11) in atypical chronic myeloid leukaemia fuses BCR to PDGFRA.

21 January 2018

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Chronic myeloproliferative disorders with rearrangement of the platelet-derived growth factor alpha receptor: a new clinical target for STI571/Glivec

21 January 2018

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Molecular and cytogenetic characterization of a novel translocation t(4;22) involving the breakpoint cluster region and platelet-derived growth factor receptor-alpha genes in a patient with atypical chronic myeloid leukemia

21 January 2018

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Treatment of hypereosinophilic syndrome with imatinib mesilate

21 January 2018

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Response of idiopathic hypereosinophilic syndrome to treatment with imatinib mesylate

21 January 2018

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Efficacy of imatinib mesylate in the treatment of idiopathic hypereosinophilic syndrome

21 January 2018

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The FIP1 gene encodes a component of a yeast pre-mRNA polyadenylation factor that directly interacts with poly(A) polymerase

21 January 2018

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Discovery of a fusion kinase in EOL-1 cells and idiopathic hypereosinophilic syndrome

21 January 2018

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The EOL-1 cell line as an in vitro model for the study of FIP1L1-PDGFRA-positive chronic eosinophilic leukemia

21 January 2018

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The FIP1L1-PDGFRalpha fusion tyrosine kinase in hypereosinophilic syndrome and chronic eosinophilic leukemia: implications for diagnosis, classification, and management.

21 January 2018

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G-CSF receptor truncations found in SCN/AML relieve SOCS3-controlled inhibition of STAT5 but leave suppression of STAT3 intact

21 January 2018

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Platelet-derived growth factor (PDGF) receptor-alpha activates c-Jun NH2-terminal kinase-1 and antagonizes PDGF receptor-beta -induced phenotypic transformation

21 January 2018

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Small-molecule control of insulin and PDGF receptor signaling and the role of membrane attachment

21 January 2018

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The roles of FLT3 in hematopoiesis and leukemia

21 January 2018

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Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors

21 January 2018

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Definition of an inhibitory juxtamembrane WW-like domain in the platelet-derived growth factor beta receptor

21 January 2018

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PDGFRA activating mutations in gastrointestinal stromal tumors.

21 January 2018

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Molecular remission and reversal of myelofibrosis in response to imatinib mesylate treatment in patients with the myeloproliferative variant of hypereosinophilic syndrome

21 January 2018

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Sustained molecular response with imatinib in a leukemic form of idiopathic hypereosinophilic syndrome in relapse after allograft.

21 January 2018

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Complete molecular remission of chronic eosinophilic leukemia complicated by CNS disease after targeted therapy with imatinib

21 January 2018

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Myeloid blast crisis evolving during imatinib treatment of an FIP1L1-PDGFR alpha-positive chronic myeloproliferative disease with prominent eosinophilia

21 January 2018

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PKC412 overcomes resistance to imatinib in a murine model of FIP1L1-PDGFRα-induced myeloproliferative disease.

21 January 2018

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Elevated serum tryptase levels identify a subset of patients with a myeloproliferative variant of idiopathic hypereosinophilic syndrome associated with tissue fibrosis, poor prognosis, and imatinib responsiveness

21 January 2018

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Response to imatinib mesylate in patients with chronic myeloproliferative diseases with rearrangements of the platelet-derived growth factor receptor beta

21 January 2018

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A 2-year-old with atypical CML with a t(5;12)(q33;p13) treated successfully with imatinib mesylate

21 January 2018

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Imatinib mesylate elicits positive clinical response in atypical chronic myeloid leukemia involving the platelet-derived growth factor receptor beta

21 January 2018

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Activity of STI571 in chronic myelomonocytic leukemia with a platelet-derived growth factor beta receptor fusion oncogene

21 January 2018

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Evidence for position effects as a variant ETV6-mediated leukemogenic mechanism in myeloid leukemias with a t(4;12)(q11-q12;p13) or t(5;12)(q31;p13).

21 January 2018

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The human GRAF gene is fused to MLL in a unique t(5;11)(q31;q23) and both alleles are disrupted in three cases of myelodysplastic syndrome/acute myeloid leukemia with a deletion 5q

21 January 2018

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AF5q31, a newly identified AF4-related gene, is fused to MLL in infant acute lymphoblastic leukemia with ins(5;11)(q31;q13q23)

21 January 2018

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A novel gene, NSD1, is fused to NUP98 in the t(5;11)(q35;p15.5) in de novo childhood acute myeloid leukemia.

21 January 2018

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Fusion of TEL/ETV6 to a novel ACS2 in myelodysplastic syndrome and acute myelogenous leukemia with t(5;12)(q31;p13)

21 January 2018

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Chronic myelocytic leukemia with eosinophilia, t(9;12)(q34;p13), and ETV6-ABL gene rearrangement: case report and review of the literature

21 January 2018

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Constitutive kinase activation of the TEL-Syk fusion gene in myelodysplastic syndrome with t(9;12)(q22;p12).

21 January 2018

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The 8p11 myeloproliferative syndrome: a distinct clinical entity caused by constitutive activation of FGFR1

21 January 2018

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Fibroblast growth factor receptor 1 is fused to FIM in stem-cell myeloproliferative disorder with t(8;13)

21 January 2018

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The t(8;13)(p11;q11-12) rearrangement associated with an atypical myeloproliferative disorder fuses the fibroblast growth factor receptor 1 gene to a novel gene RAMP

21 January 2018

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FGFR1 is fused with a novel zinc-finger gene, ZNF198, in the t(8;13) leukaemia/lymphoma syndrome

21 January 2018

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The t(8;22) in chronic myeloid leukemia fuses BCR to FGFR1: transforming activity and specific inhibition of FGFR1 fusion proteins

21 January 2018

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Fusion of the BCR and the fibroblast growth factor receptor-1 (FGFR1) genes as a result of t(8;22)(p11;q11) in a myeloproliferative disorder: the first fusion gene involving BCR but not ABL.

21 January 2018

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Endogenous retroviral sequence is fused to FGFR1 kinase in the 8p12 stem-cell myeloproliferative disorder with t(8;19)(p12;q13.3).

21 January 2018

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Identification of a novel gene, FGFR1OP2, fused to FGFR1 in 8p11 myeloproliferative syndrome

21 January 2018

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8p11 myeloproliferative syndrome with a novel t(7;8) translocation leading to fusion of the FGFR1 and TIF1 genes

21 January 2018

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Identification of four new translocations involving FGFR1 in myeloid disorders

21 January 2018

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The ins and outs of fibroblast growth factors

21 January 2018

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Characterization of FIM-FGFR1, the fusion product of the myeloproliferative disorder-associated t(8;13) translocation

21 January 2018

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ZNF198-FGFR1 transforms Ba/F3 cells to growth factor independence and results in high level tyrosine phosphorylation of STATS 1 and 5

21 January 2018

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Distinct stem cell myeloproliferative/T lymphoma syndromes induced by ZNF198-FGFR1 and BCR-FGFR1 fusion genes from 8p11 translocations

21 January 2018

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PKC412 inhibits the zinc finger 198-fibroblast growth factor receptor 1 fusion tyrosine kinase and is active in treatment of stem cell myeloproliferative disorder

21 January 2018

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21 January 2018

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Brief report: clonal proliferation of type 2 helper T cells in a man with the hypereosinophilic syndrome

21 January 2018

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Expansion of cytokine-producing CD4-CD8- T cells associated with abnormal Fas expression and hypereosinophilia.

21 January 2018

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Eosinophilia associated with clonal T-cell proliferation

21 January 2018

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21 January 2018

Identifiers

DOI

10.1159/000085559

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12 August 2017

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PubMed ID

15995322