TSAO derivatives the first non-peptide inhibitors of HIV-1 RT dimerization. (Q36186788)

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30 December 2019

review article

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title

TSAO derivatives the first non-peptide inhibitors of HIV-1 RT dimerization (English)

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30 December 2019

3

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30 December 2019

author name string

María-José Camarasa

series ordinal

1

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30 December 2019

Sonsoles Velázquez

series ordinal

2

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30 December 2019

María-Jesús Pérez-Pérez

series ordinal

4

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30 December 2019

publication date

1 January 2005

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Antiviral Chemistry & Chemotherapy

30 December 2019

published in

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30 December 2019

volume

16

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30 December 2019

issue

3

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30 December 2019

page(s)

147-153

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Chimeric HIV-1 and feline immunodeficiency virus reverse transcriptases: critical role of the p51 subunit in the structural integrity of heterodimeric lentiviral DNA polymerases

30 December 2019

cites work

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2',5'-Bis-O-(tert-butyldimethylsilyl)-3'-spiro-5''-(4''-amino-1'',2''- oxathiole-2'',2'-dioxide)pyrimidine (TSAO) nucleoside analogues: highlyselective inhibitors of human immunodeficiency virus type 1 that are targeted at the viral reverse transcri

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Sensitivity of (138 Glu-->Lys) mutated human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) to HIV-1-specific RT inhibitors

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Analysis of inhibition of retroviral reverse transcriptase

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Exploitation of the low fidelity of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase and the nucleotide composition bias in the HIV-1 genome to alter the drug resistance development of HIV.

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Subunit specificity of mutations that confer resistance to nonnucleoside inhibitors in human immunodeficiency virus type 1 reverse transcriptase

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TSAO compounds: the comprehensive story of a unique family of HIV-1 specific inhibitors of reverse transcriptase

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Novel [2',5'-bis-O-(tert-butyldimethylsilyl)-beta-D-ribofuranosyl]- 3'-spiro-5''-(4''-amino-1'',2''-oxathiole-2'',2" -dioxide) derivatives with anti-HIV-1 and anti-human-cytomegalovirus activity.

21 January 2018

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Dimerization kinetics of HIV-1 and HIV-2 reverse transcriptase: a two step process

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The p51 subunit of human immunodeficiency virus type 1 reverse transcriptase is essential in loading the p66 subunit on the template primer

21 January 2018

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Structure of unliganded HIV-1 reverse transcriptase at 2.7 A resolution: implications of conformational changes for polymerization and inhibition mechanisms

21 January 2018

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Structure of a covalently trapped catalytic complex of HIV-1 reverse transcriptase: implications for drug resistance

21 January 2018

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Crystal structure of human immunodeficiency virus type 1 reverse transcriptase complexed with double-stranded DNA at 3.0 A resolution shows bent DNA

21 January 2018

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21 January 2018

The retroviral enzymes

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Crystal structure at 3.5 A resolution of HIV-1 reverse transcriptase complexed with an inhibitor

21 January 2018

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4"-H-TSAO-T, a novel prototype in the HIV-1 specific TSAO family.

21 January 2018

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Synthesis of 3' '-substituted TSAO derivatives with anti-HIV-1 and anti-HIV-2 activity through an efficient palladium-catalyzed cross-coupling approach

21 January 2018

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The beta7-beta8 loop of the p51 subunit in the heterodimeric (p66/p51) human immunodeficiency virus type 1 reverse transcriptase is essential for the catalytic function of the p66 subunit

21 January 2018

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Site-directed mutagenesis of human immunodeficiency virus type 1 reverse transcriptase at amino acid position 138.

21 January 2018

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Nonnucleoside inhibitor binding affects the interactions of the fingers subdomain of human immunodeficiency virus type 1 reverse transcriptase with DNA

21 January 2018

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TSAO analogues. Stereospecific synthesis and anti-HIV-1 activity of 1-[2',5'-bis-O-(tert-butyldimethylsilyl)-beta-D-ribofuranosyl]-3'-spiro -5''- (4''-amino-1'',2''-oxathiole 2'',2''-dioxide) pyrimidine and pyrimidine-modified nucleosides

21 January 2018

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21 January 2018

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High resolution structures of HIV-1 RT from four RT-inhibitor complexes

21 January 2018

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The structure of unliganded reverse transcriptase from the human immunodeficiency virus type 1

21 January 2018

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Identification of a putative binding site for [2',5'-bis-O-(tert-butyldimethylsilyl)-beta-D-ribofuranosyl]-3'-spiro-5''-(4''-amino-1'',2''-oxathiole-2'',2''-dioxide)thymine (TSAO) derivatives at the p51-p66 interface of HIV-1 reverse transcriptase.

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Steered molecular dynamics simulation on the binding of NNRTI to HIV-1 RT.

21 January 2018

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Human immunodeficiency virus type 1 reverse transcriptase dimer destabilization by 1-[Spiro[4"-amino-2",2" -dioxo-1",2" -oxathiole-5",3'-[2', 5'-bis-O-(tert-butyldimethylsilyl)-beta-D-ribofuranosyl]]]-3-ethylthy mine

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Inhibitor binding alters the directions of domain motions in HIV-1 reverse transcriptase

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3'-Spiro nucleosides, a new class of specific human immunodeficiency virus type 1 inhibitors: synthesis and antiviral activity of [2', 5'-bis-O-(tert-butyldimethylsilyl)-.beta.-D-xylo- and -ribofuranose]-3'-spiro-5''-[4''-amino-1'', 2''-oxathiole 2''

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