Endogenous morphine: opening new doors for the treatment of pain and addiction (Q36194064)

12 August 2017

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title

Endogenous morphine: opening new doors for the treatment of pain and addiction (English)

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12 August 2017

Stephen C Pryor

1

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12 August 2017

Wei Zhu

2

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12 August 2017

Patrick Cadet

3

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12 August 2017

Enrica Bianchi

4

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12 August 2017

Massimo Guarna

5

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12 August 2017

George B Stefano

6

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12 August 2017

language of work or name

English

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publication date

1 July 2005

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Expert Opinion on Biological Therapy

12 August 2017

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12 August 2017

5

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12 August 2017

7

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12 August 2017

893-906

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Signal transduction mechanisms involving nitric oxide

12 August 2017

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https://api.crossref.org/works/10.1517%2F14712598.5.7.893

Basal nitric oxide limits immune, nervous and cardiovascular excitation: human endothelia express a mu opiate receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.5.7.893

Nitric oxide synthase: expression and expressional control of the three isoforms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.5.7.893

Mapping of neural nitric oxide synthase in the rat suggests frequent co-localization with NADPH diaphorase but not with soluble guanylyl cyclase, and novel paraneural functions for nitrinergic signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.5.7.893

Characterization of nociceptive responses and spinal releases of nitric oxide metabolites and glutamate evoked by different concentrations of formalin in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.5.7.893

7-Nitro indazole, an inhibitor of nitric oxide synthase, exhibits anti-nociceptive activity in the mouse without increasing blood pressure

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.5.7.893

Spinal nitric oxide synthesis inhibition blocks NMDA-induced thermal hyperalgesia and produces antinociception in the formalin test in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.5.7.893

Intrathecal administration of a new nitric oxide donor, NOC-18, produces acute thermal hyperalgesia in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.5.7.893

Anti-nociceptive activity of nitric oxide synthase inhibitors in the mouse: dissociation between the effect of L-NAME and L-NMMA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.5.7.893

L-NG-nitro arginine methyl ester exhibits antinociceptive activity in the mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.5.7.893

Evidence for the involvement of the nitric oxide-cGMP pathway in the antinociception of morphine in the formalin test.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.5.7.893

Activation of a NO-cyclic GMP system by NO donors potentiates beta-endorphin-induced antinociception in the mouse.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.5.7.893

Intracerebroventricular administration of a nitric oxide-releasing compound, NOC-18, produces thermal hyperalgesia in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.5.7.893

Mechanisms underlying the nociception and paw oedema caused by injection of glutamate into the mouse paw.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.5.7.893

The molecular mechanism of central analgesia induced by morphine or carbachol and the L-arginine-nitric oxide-cGMP pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.5.7.893

Analgesia by direct antagonism of nociceptor sensitization involves the arginine-nitric oxide-cGMP pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.5.7.893

The molecular mechanism of action of peripheral morphine analgesia: stimulation of the cGMP system via nitric oxide release

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.5.7.893

The dual effect of a nitric oxide donor in nociception.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.5.7.893

Dual effect of local application of nitric oxide donors in a model of incision pain in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.5.7.893

Analgesic effect of L-arginine in patients with persistent pain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.5.7.893

Double-blind evaluation of transdermal nitroglycerine as adjuvant to oral morphine for cancer pain management

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.5.7.893

Crossover study of glyceryl trinitrate patches for controlling pain in women with severe dysmenorrhoea

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.5.7.893

Endogenous nitric oxide is required for tonic cholinergic inhibition of spinal mechanical transmission.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.5.7.893

Sildenafil-induced peripheral analgesia and activation of the nitric oxide-cyclic GMP pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.5.7.893

Effect of topical administration of l‐arginine on formalin‐induced nociception in the mouse: a dual role of peripherally formed NO in pain modulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.5.7.893

Sildenafil, a phosphodiesterase-5 inhibitor, enhances the antinociceptive effect of morphine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.5.7.893

Antibodies as a means of isolating and characterizing biologically active substances: presence of a non-peptide, morphine-like compound in the central nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.5.7.893

A Nonpeptide Morphine-Like Compound: Immunocytochemical Localization in the Mouse Brain

21 January 2018

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https://api.crossref.org/works/10.1517%2F14712598.5.7.893

A non-peptide morphine-like compound from brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.5.7.893

Morphine and other opiates from beef brain and adrenal

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.5.7.893

Presence and formation of codeine and morphine in the rat

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.5.7.893

Opiate-like substances in an invertebrate, an opiate receptor on invertebrate and human immunocytes, and a role in immunosuppression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.5.7.893

Possible role of endogenous morphine and codeine on growth regulation of lung tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.5.7.893

Identification of morphine in the adrenal medullary chromaffin PC-12 cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.5.7.893

Lipopolysaccharide increases endogenous morphine levels in rat brain.

21 January 2018

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https://api.crossref.org/works/10.1517%2F14712598.5.7.893

Presence of reticuline in rat brain: a pathway for morphine biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.5.7.893

Identification of the convulsant opiate thebaine in mammalian brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.5.7.893

Highly sensitive gas chromatographic-tandem mass spectrometric method for the determination of morphine and codeine in serum and urine in the femtomolar range

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.5.7.893

Synthesis of the skeleton of the morphine molecule by mammalian liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.5.7.893

Transformation of thebaine to oripavine, codeine, and morphine by rat liver, kidney, and brain microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.5.7.893

Endogenous formation of morphine in human cells

21 January 2018

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https://api.crossref.org/works/10.1517%2F14712598.5.7.893

Immunocytochemical localization of endogenous codeine and morphine

21 January 2018

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https://api.crossref.org/works/10.1517%2F14712598.5.7.893

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.5.7.893

Opioid Inhibition of Dopamine Release from Nervous Tissue of Mytilus edulis and Octopus bimaculatus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.5.7.893

Molecular identification and functional expression of mu 3, a novel alternatively spliced variant of the human mu opiate receptor gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.5.7.893

Endogenous morphine modulates acute thermonociception in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.5.7.893

Effect of ?-Endorphin and naloxone on acquisition, memory, and retrieval of shuttle avoidance and habituation learning in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.5.7.893

Relationship between morphine and etonitazene-induced working memory impairment and analgesia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.5.7.893

Autoimmunovascular regulation: morphine and anandamide and ancondamide stimulated nitric oxide release

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.5.7.893

Perspectives on the N-methyl-D-aspartate/nitric oxide cascade and opioid tolerance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.5.7.893

Comparison of the effects of specific and nonspecific inhibition of nitric oxide synthase on morphine analgesia, tolerance and dependence in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.5.7.893

Evidence that nitric oxide-glutamate cascade modulates spinal antinociceptive effect of morphine: a behavioural and microdialysis study in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.5.7.893

II - Prostaglandin hyperalgesia: The peripheral analgesic activity of morphine, enkephalins and opioid antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.5.7.893

Prostaglandin hyperalgesia, V: A peripheral analgesic receptor for opiates

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.5.7.893

The peripheral antinociceptive effect induced by morphine is associated with ATP-sensitive K(+) channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.5.7.893

Role of nitric oxide in the induction and expression of morphine tolerance and dependence in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.5.7.893

Differential effects of nitric oxide synthase inhibitor, 7-nitroindazole, on discriminative stimulus and somatic effects of naloxone in morphine-dependent rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.5.7.893

Pharmacological modulation of secondary mediator systems--cyclic AMP and cyclic GMP--on inflammatory hyperalgesia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.5.7.893

Functionally differentiating two neuronal nitric oxide synthase isoforms through antisense mapping: evidence for opposing NO actions on morphine analgesia and tolerance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.5.7.893

Experimental mononeuropathy reduces the antinociceptive effects of morphine: implications for common intracellular mechanisms involved in morphine tolerance and neuropathic pain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.5.7.893

Modulation of dural nociceptor mechanosensitivity by the nitric oxide-cyclic GMP signaling cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.5.7.893

Increase of nitric oxide by L-arginine potentiates beta-endorphin- but not mu-, delta- or kappa-opioid agonist-induced antinociception in the mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.5.7.893

L-arginine exerts a dual role in nociceptive processing in the brain: involvement of the kyotorphin-Met-enkephalin pathway and NO-cyclic GMP pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.5.7.893

Efferent projections of the periaqueductal gray in the rabbit

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.5.7.893

The induction of pain: an integrative review.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.5.7.893

Effect of nitric oxide production on the redox modulatory site of the NMDA receptor-channel complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.5.7.893

A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.5.7.893

The NMDA receptor antagonists, LY274614 and MK-801, and the nitric oxide synthase inhibitor, NG-nitro-L-arginine, attenuate analgesic tolerance to the mu-opioid morphine but not to kappa opioids

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.5.7.893

Antagonism of LPS and IFN-gamma induction of iNOS in human saphenous vein endothelium by morphine and anandamide by nitric oxide inhibition of adenylate cyclase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.5.7.893

Effects of endogenous morphine deprivation on memory retention of passive avoidance learning in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.5.7.893

Inhibition of nitric oxide synthase enhances morphine antinociception in the rat spinal cord

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.5.7.893

Inhibition of nitric oxide synthase attenuates the development of morphine tolerance and dependence in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.5.7.893

Morphine coupling to invertebrate immunocyte nitric oxide release is dependent on intracellular calcium transients

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.5.7.893

Endothelium-derived relaxing factor release on activation of NMDA receptors suggests role as intercellular messenger in the brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.5.7.893

21 January 2018

Identifiers

DOI

10.1517/14712598.5.7.893

1 reference

12 August 2017

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