Systems-ADME/Tox: resources and network approaches (Q36212769)

12 August 2017

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title

Systems-ADME/Tox: resources and network approaches (English)

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12 August 2017

1

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12 August 2017

27 July 2005

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Journal of Pharmacological and Toxicological Methods

12 August 2017

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12 August 2017

53

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12 August 2017

1

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12 August 2017

38-66

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Global expression analysis of N-methyl-N'-nitro-N-nitrosoguanidine-induced rat stomach carcinomas using oligonucleotide microarrays.

12 August 2017

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https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Long-term alteration of gene expression without morphological change in testis after neonatal exposure to genistein in mice: toxicogenomic analysis using cDNA microarray

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Gene expression profiles and genetic damage in benzo(a)pyrene diol epoxide-exposed TK6 cells

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

An integrated approach for inference and mechanistic modeling for advancing drug development

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Intestinal membrane transport of drugs and nutrients: genomics of membrane transporters using expression microarrays

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Analysis of ATP-binding cassette transporter expression in drug-selected cell lines by a microarray dedicated to multidrug resistance.

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Illuminating drug discovery with biological pathways

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Clofibrate-induced gene expression changes in rat liver: a cross-laboratory analysis using membrane cDNA arrays

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Quantitative structure-metabolism relationship modeling of metabolic N-dealkylation reaction rates

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Kohonen maps for prediction of binding to human cytochrome P450 3A4.

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Network biology: understanding the cell's functional organization

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Applications of gene arrays in environmental toxicology: fingerprints of gene regulation associated with cadmium chloride, benzo(a)pyrene, and trichloroethylene

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

SXR, a novel steroid and xenobiotic-sensing nuclear receptor

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

A new statistical approach to predicting aromatic hydroxylation sites. Comparison with model-based approaches

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Predicting Biotransformation Potential from Molecular Structure

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Gene modulation by the cyclooxygenase inhibitor, sulindac sulfide, in human colorectal carcinoma cells: possible link to apoptosis

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

New methods in predictive metabolism

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Chemogenomics: an emerging strategy for rapid target and drug discovery

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Early prediction of drug metabolism and toxicity: systems biology approach and modeling

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

RNA expression in the early characterization of hepatotoxicants in Wistar rats by high-density DNA microarrays

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Systems biology in drug discovery

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

The use and analysis of microarray data

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Pathway information for systems biology

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Treatment-specific changes in gene expression discriminate in vivo drug response in human leukemia cells

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Differential transcription factor expression in human mononuclear cells in response to amphotericin B: identification with complementary DNA microarray technology

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Integrated application of transcriptomics and metabonomics yields new insight into the toxicity due to paracetamol in the mouse

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Profiling of hepatic gene expression in rats treated with fibric acid analogs

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

The efficiency of multi-target drugs: the network approach might help drug design

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Use of a low-density microarray for studying gene expression patterns induced by hepatotoxicants on primary cultures of rat hepatocytes

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Aggregation of topological motifs in the Escherichia coli transcriptional regulatory network

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Expression of the liver Na+-independent organic anion transporting polypeptide (oatp-1) in rats with bile duct ligation

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Hepatic drug metabolism and aging

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Cluster analysis and display of genome-wide expression patterns

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Computational prediction of human drug metabolism

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Towards a new age of virtual ADME/TOX and multidimensional drug discovery

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

A novel method for visualizing nuclear hormone receptor networks relevant to drug metabolism

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

A ligand-based approach to understanding selectivity of nuclear hormone receptors PXR, CAR, FXR, LXRalpha, and LXRbeta

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Techniques: application of systems biology to absorption, distribution, metabolism, excretion and toxicity

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Present and future in vitro approaches for drug metabolism.

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Progress in predicting human ADME parameters in silico

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

A Human Drug Metabolism Database: Potential Roles in the Quantitative Predictions of Drug Metabolism and Metabolism-Related Drug-Drug Interactions

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Pharmacogenomics--drug disposition, drug targets, and side effects

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Toxicogenomics of subchronic hexachlorobenzene exposure in Brown Norway rats.

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Gene expression profile in bone marrow and hematopoietic stem cells in mice exposed to inhaled benzene

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Combining genomics, metabolome analysis, and biochemical modelling to understand metabolic networks

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

LXR/RXR ligand activation enhances basolateral efflux of beta-sitosterol in CaCo-2 cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Use of gene chip technology for the characterisation of the regulation of renal transport processes and of nephrotoxicity in rats

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Biological spectra analysis: Linking biological activity profiles to molecular structure

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Application of proteomics technologies in the investigation of the brain

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Expanded coverage of the human heart mitochondrial proteome using multidimensional liquid chromatography coupled with tandem mass spectrometry.

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Monitoring expression of genes involved in drug metabolism and toxicology using DNA microarrays

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Induction profile of rat organic anion transporting polypeptide 2 (oatp2) by prototypical drug-metabolizing enzyme inducers that activate gene expression through ligand-activated transcription factor pathways

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Organic anion transporting polypeptides of the OATP/ SLC21 family: phylogenetic classification as OATP/ SLCO superfamily, new nomenclature and molecular/functional properties

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Gene expression analysis reveals chemical-specific profiles

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Integration of clinical and gene expression endpoints to explore furan-mediated hepatotoxicity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Evidence for dynamically organized modularity in the yeast protein-protein interaction network

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Co-clustering of biological networks and gene expression data

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Comparison of basal gene expression profiles and effects of hepatocarcinogens on gene expression in cultured primary human hepatocytes and HepG2 cells

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Whither structural biology?

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Activators of the rat pregnane X receptor differentially modulate hepatic and intestinal gene expression

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

From molecular to modular cell biology

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Downregulation of lactoferrin by PPARalpha ligands: role in perturbation of hepatocyte proliferation and apoptosis

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Microarray profile analysis of toxic cocaine-induced alterations in the expression of mouse brain gene sequences: a possible 'protective' effect of buprenorphine

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

EDGE: a centralized resource for the comparison, analysis, and distribution of toxicogenomic information

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Bromobenzene-induced hepatotoxicity at the transcriptome level

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Toxicogenomics of bromobenzene hepatotoxicity: a combined transcriptomics and proteomics approach

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Gene expression profiling of rat livers reveals indicators of potential adverse effects.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Gene-expression patterns in drug-resistant acute lymphoblastic leukemia cells and response to treatment

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Discriminating two classes of toxicants through expression analysis of HepG2 cells with DNA arrays

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Proteomics: characterizing the cogs in the machinery of life

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Systems biology: integrating technology, biology, and computation

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

7 January 2021

The digital code of DNA.

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https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

The impact of systems approaches on biological problems in drug discovery

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Identification of a gene expression profile that discriminates indirect-acting genotoxins from direct-acting genotoxins

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Assessment of cisplatin-induced nephrotoxicity by microarray technology

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Gene expression profiling reveals multiple toxicity endpoints induced by hepatotoxicants

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Multidrug resistance protein 2 (MRP2) transports HIV protease inhibitors, and transport can be enhanced by other drugs

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Effect of age and gender on the activity of human hepatic CYP3A

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Discovering regulatory and signalling circuits in molecular interaction networks

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Integrated genomic and proteomic analyses of a systematically perturbed metabolic network

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Changes in global gene and protein expression during early mouse liver carcinogenesis induced by non-genotoxic model carcinogens oxazepam and Wyeth-14,643.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Pharmacogenetics of cytochrome P450 and its applications in drug therapy: the past, present and future

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Lethality and centrality in protein networks

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

The large-scale organization of metabolic networks

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Characterization of the human OATP-C (SLC21A6) gene promoter and regulation of liver-specific OATP genes by hepatocyte nuclear factor 1 alpha

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Hepatocyte nuclear factor 1 alpha: a key mediator of the effect of bile acids on gene expression

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Gene expression analysis of peroxisome proliferators- and phenytoin-induced hepatotoxicity using cDNA microarray

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Gene expression profile in the livers of rats orally administered ethinylestradiol for 28 days using a microarray technique

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Applications of microarrays with toxicologically relevant genes (tox genes) for the evaluation of chemical toxicants in Sprague Dawley rats in vivo and human hepatocytes in vitro

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Gene expression analysis of the rat testis after treatment with di(2-ethylhexyl) phthalate using cDNA microarray and real-time RT-PCR.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Organic anion-transporting polypeptide (OATP) transporter family and drug disposition

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Drug metabolism and ageing

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Computational systems biology

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Systems biology: a brief overview

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Modeling of human cytochrome p450-mediated drug metabolism using unsupervised machine learning approach

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Overview on the application of transcription profiling using selected nephrotoxicants for toxicology assessment

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Valproic acid teratogenicity: a toxicogenomics approach

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Gene expression profiles in rat intestine identify pathways for 1,25-dihydroxyvitamin D(3) stimulated calcium absorption and clarify its immunomodulatory properties

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Modulation of gene expression by cancer chemopreventive dithiolethiones through the Keap1-Nrf2 pathway. Identification of novel gene clusters for cell survival

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Carnitine transport by organic cation transporters and systemic carnitine deficiency

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Gene Expression in the Human Intestine and Correlation with Oral Valacyclovir Pharmacokinetic Parameters

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

cDNA microarray gene expression analysis and toxicological phenotype for anticancer drug

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

cDNA microarray gene expression profiling of hydroxyurea, paclitaxel, and p-anisidine, genotoxic compounds with differing tumorigenicity results

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

A map of the interactome network of the metazoan C. elegans

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Microarray analysis in human hepatocytes suggests a mechanism for hepatotoxicity induced by trovafloxacin.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Regulation of DNA replication fork genes by 17beta-estradiol

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

A common set of immediate-early response genes in liver regeneration and hyperplasia

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Database development in toxicogenomics: issues and efforts

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

A gene expression signature for oxidant stress/reactive metabolites in rat liver

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

An evaluation of a low-density DNA microarray using cytochrome P450 inducers

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

A proteomic investigation of drug-induced steatosis in rat liver

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Etomoxir-induced oxidative stress in HepG2 cells detected by differential gene expression is confirmed biochemically

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Network motifs: simple building blocks of complex networks

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Evidence for inverse effects of OATP-C (SLC21A6) 5 and 1b haplotypes on pravastatin kinetics

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

The challenges of modeling mammalian biocomplexity

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Understanding 'Global' Systems Biology: Metabonomics and the Continuum of Metabolism

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Pathway studio—the analysis and navigation of molecular networks

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

A novel method for generation of signature networks as biomarkers from complex high throughput data

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Biological networks and analysis of experimental data in drug discovery

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Polymorphisms of OATP-C (SLC21A6) and OAT3 (SLC22A8) genes: consequences for pravastatin pharmacokinetics

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Genetic polymorphisms of human organic anion transporters OATP-C (SLC21A6) and OATP-B (SLC21A9): allele frequencies in the Japanese population and functional analysis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Involvement of organic anion transporting polypeptides in the transport of troglitazone sulfate: implications for understanding troglitazone hepatotoxicity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Expression of hepatic transporters OATP-C and MRP2 in primary sclerosing cholangitis.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Integration of chemical-genetic and genetic interaction data links bioactive compounds to cellular target pathways

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Effect of age on in vitro triazolam biotransformation in male human liver microsomes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Detection of functional modules from protein interaction networks.

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Interaction networks: coordinating responses to xenobiotic exposure

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Potential effects of tetrodotoxin exposure to human glial cells postulated using microarray approach

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Expression profiling of acetaminophen liver toxicity in mice using microarray technology

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Modular organization of cellular networks

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Differential expression of genes encoding immunomodulatory proteins in response to amphotericin B in human mononuclear cells identified by cDNA microarray analysis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Gene expression analysis in the ventral prostate of rats exposed to vinclozolin or procymidone

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Regulation of rat organic anion transporters in bile salt-induced cholestatic hepatitis: effect of ursodeoxycholate

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Aminorex, fenfluramine, and chlorphentermine are serotonin transporter substrates. Implications for primary pulmonary hypertension.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Genomics and proteomics analysis of acetaminophen toxicity in mouse liver

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

MDR1 genotype-related pharmacokinetics and pharmacodynamics.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Novel single nucleotide polymorphisms of organic cation transporter 1 (SLC22A1) affecting transport functions

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Organic anion transporting polypeptide mediates organic anion/HCO3- exchange

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Gene expression analysis of the lung following paraquat administration in rats using DNA microarray

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Up-regulation of transporters of the MRP family by drugs and toxins

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Module networks: identifying regulatory modules and their condition-specific regulators from gene expression data

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Discovering molecular pathways from protein interaction and gene expression data

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Identification of transcriptome profiles for the DNA-damaging agents bleomycin and hydrogen peroxide in L5178Y mouse lymphoma cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Susceptibility of rats to mammary gland carcinogenesis by the food-derived carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) varies with age and is associated with the induction of differential gene expression

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

From large networks to small molecules

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Gemfibrozil and its glucuronide inhibit the organic anion transporting polypeptide 2 (OATP2/OATP1B1:SLC21A6)-mediated hepatic uptake and CYP2C8-mediated metabolism of cerivastatin: analysis of the mechanism of the clinically relevant drug-drug inter

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Inhibition of transporter-mediated hepatic uptake as a mechanism for drug-drug interaction between cerivastatin and cyclosporin A.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Protein complexes and functional modules in molecular networks

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

ADME-AP: a database of ADME associated proteins.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Toxicogenomics in Predictive Toxicology in Drug Development

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

cDNA microarray analysis reveals chop-10 plays a key role in Sertoli cell injury induced by bisphenol A.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Characterization of the human heart mitochondrial proteome

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Using a customized DNA microarray for expression profiling of the estrogen-responsive genes to evaluate estrogen activity among natural estrogens and industrial chemicals.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Identification of differentially regulated transcripts in mouse striatum following methamphetamine treatment--an oligonucleotide microarray approach.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Identification of toxicologically predictive gene sets using cDNA microarrays

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Identification of platform-independent gene expression markers of cisplatin nephrotoxicity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Polymorphisms in OATP-C: identification of multiple allelic variants associated with altered transport activity among European- and African-Americans

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Human organic anion transporting polypeptide-C (SLC21A6) is a major determinant of rifampin-mediated pregnane X receptor activation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

ArrayTrack--supporting toxicogenomic research at the U.S. Food and Drug Administration National Center for Toxicological Research

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Functional modules by relating protein interaction networks and gene expression.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Phenytoin treatment reduces atherosclerosis in mice through mechanisms independent of plasma HDL-cholesterol concentration.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Diverse roles of the nuclear orphan receptor CAR in regulating hepatic genes in response to phenobarbital

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

The toxicogenomics of nuclear receptor agonists

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Overview of an interlaboratory collaboration on evaluating the effects of model hepatotoxicants on hepatic gene expression

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Biochemical and microarray analyses of bupivacaine-induced apoptosis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Global protein function prediction from protein-protein interaction networks.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Subchronic exposure to TCDD, PeCDF, PCB126, and PCB153: effect on hepatic gene expression

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Reconstruction and functional characterization of the human mitochondrial metabolic network based on proteomic and biochemical data

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Role of orphan nuclear receptors in the regulation of drug-metabolising enzymes.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

ATP-binding cassette transporter A1 (ABCA1) functions as a cholesterol efflux regulatory protein

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Development of a DNA Microarray for Toxicology Based on Hepatotoxin-Regulated Sequences.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Identifying toxic mechanisms using DNA microarrays: evidence that an experimental inhibitor of cell adhesion molecule expression signals through the aryl hydrocarbon nuclear receptor

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Clustering of hepatotoxins based on mechanism of toxicity using gene expression profiles

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Effects of co-administration of antioxidants and arsenicals on the rat urinary bladder epithelium

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Inheritance and drug response

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Pharmacogenetics: inherited variation in amino acid sequence and altered protein quantity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

In silico multicellular systems biology and minimal genomes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Gene expression changes induced in mouse liver by di(2-ethylhexyl) phthalate

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Identification and characterization of metallothionein-1 and -2 gene expression in the context of (+/-)3,4-methylenedioxymethamphetamine-induced toxicity to brain dopaminergic neurons.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Liver gene expression in rats in response to the peroxisome proliferator-activated receptor-alpha agonist ciprofibrate

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Persistence of gene expression changes in stomach mucosae induced by short-term N-methyl-N'-nitro-N-nitrosoguanidine treatment and their presence in stomach cancers

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Human membrane transporter database: a Web-accessible relational database for drug transport studies and pharmacogenomics

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Detection of regulatory circuits by integrating the cellular networks of protein-protein interactions and transcription regulation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Mechanisms of benzene-induced hematotoxicity and leukemogenicity: cDNA microarray analyses using mouse bone marrow tissue

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Analysis of gene expression in carbon tetrachloride-treated rat livers using a novel bioarray technology

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

TopNet: a tool for comparing biological sub-networks, correlating protein properties with topological statistics

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Genetic polymorphisms in human proton-dependent dipeptide transporter PEPT1: implications for the functional role of Pro586.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Structural biology and function of solute transporters: implications for identifying and designing substrates

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Modeling of active transport systems

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

Gene expression microarray data analysis for toxicology profiling

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2005.05.005

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1016/J.VASCN.2005.05.005

1 reference

12 August 2017

1 reference

PubMed ID

16054403