The effects of 5-fluoruracil treatment on 3'-fluoro-3'-deoxythymidine (FLT) transport and metabolism in proliferating and non-proliferating cultures of human tumor cells. (Q36213599)

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English	The effects of 5-fluoruracil treatment on 3'-fluoro-3'-deoxythymidine (FLT) transport and metabolism in proliferating and non-proliferating cultures of human tumor cells.	scientific article

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31 January 2020

The effects of 5-fluoruracil treatment on 3'-fluoro-3'-deoxythymidine (FLT) transport and metabolism in proliferating and non-proliferating cultures of human tumor cells (English)

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31 January 2020

1

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31 January 2020

author name string

Lena J McLaughlin

2

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31 January 2020

Kenneth A Krohn

3

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31 January 2020

Jeffrey L Schwartz

4

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31 January 2020

publication date

5 May 2012

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31 January 2020

Nuclear Medicine and Biology

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31 January 2020

39

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31 January 2020

7

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31 January 2020

970-976

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31 January 2020

The role of nucleoside/nucleotide transport and metabolism in the uptake and retention of 3'-fluoro-3'-deoxythymidine in human B-lymphoblast cells.

1 reference

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Induction of thymidine kinase 1 after 5-fluorouracil as a mechanism for 3'-deoxy-3'-[18F]fluorothymidine flare.

1 reference

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1 October 2017

Different modes of transport for 3H-thymidine, 3H-FLT, and 3H-FMAU in proliferating and nonproliferating human tumor cells

1 reference

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1 October 2017

Biodistribution and uptake of 3'-deoxy-3'-fluorothymidine in ENT1-knockout mice and in an ENT1-knockdown tumor model

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Altered tissue 3'-deoxy-3'-[18F]fluorothymidine pharmacokinetics in human breast cancer following capecitabine treatment detected by positron emission tomography

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Chk1-dependent slowing of S-phase progression protects DT40 B-lymphoma cells against killing by the nucleoside analogue 5-fluorouracil.

1 reference

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Elevation of radiolabelled thymidine uptake in RIF-1 fibrosarcoma and HT29 colon adenocarcinoma cells after treatment with thymidylate synthase inhibitors

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Positron emission tomography measurement of tumor metabolism and growth: its expanding role in oncology

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Control of dTTP pool size by anaphase promoting complex/cyclosome is essential for the maintenance of genetic stability

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Novel chemical strategies for thymidylate synthase inhibition

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[18F]FLT-PET in oncology: current status and opportunities

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Metabolism of 3'-deoxy-3'-[F-18]fluorothymidine in proliferating A549 cells: validations for positron emission tomography

1 reference

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1 October 2017

Effect of p53 activation on cell growth, thymidine kinase-1 activity, and 3'-deoxy-3'fluorothymidine uptake

1 reference

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Monitoring tumor cell proliferation by targeting DNA synthetic processes with thymidine and thymidine analogs.

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1 October 2017

3'-deoxy-3'-[18F]fluorothymidine as a new marker for monitoring tumor response to antiproliferative therapy in vivo with positron emission tomography.

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Novel aspects of resistance to drugs targeted to dihydrofolate reductase and thymidylate synthase

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Thymidylate synthase inhibitors

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12 December 2020

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10.1016/J.NUCMEDBIO.2012.03.009

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31 January 2020

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31 January 2020

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31 January 2020

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