High throughput cross-interaction measures for human IgG1 antibodies correlate with clearance rates in mice (Q36213701)

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16 February 2020

title

High throughput cross-interaction measures for human IgG1 antibodies correlate with clearance rates in mice (English)

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16 February 2020

1

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16 February 2020

Tushar Jain

3

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16 February 2020

K. Dane Wittrup

10

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16 February 2020

author name string

Tingwan Sun

2

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16 February 2020

Isabelle Caffry

4

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16 February 2020

Yao Yu

5

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16 February 2020

Yuan Cao

6

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16 February 2020

Heather Lynaugh

7

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16 February 2020

Michael Brown

8

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16 February 2020

Maximiliano Vásquez

9

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16 February 2020

Yingda Xu

11

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16 February 2020

publication date

1 January 2015

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16 February 2020

published in

Monoclonal Antibodies

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16 February 2020

volume

7

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16 February 2020

issue

4

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16 February 2020

page(s)

770-777

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Antibody engineering for increased potency, breadth and half-life

16 February 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4622737

In silico selection of therapeutic antibodies for development: viscosity, clearance, and chemical stability

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4622737

Improving monoclonal antibody selection and engineering using measurements of colloidal protein interactions

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4622737

High-throughput screening for developability during early-stage antibody discovery using self-interaction nanoparticle spectroscopy

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4622737

Addressing polyspecificity of antibodies selected from an in vitro yeast presentation system: a FACS-based, high-throughput selection and analytical tool

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4622737

Death receptor 5 agonistic antibody PRO95780: preclinical pharmacokinetics and concentration-effect relationship support clinical dose and regimen selection

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4622737

High-throughput analysis of concentration-dependent antibody self-association.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4622737

Enhanced antibody half-life improves in vivo activity

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4622737

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4622737

Antibody pharmacokinetics and pharmacodynamics

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4622737

Engineered human IgG antibodies with longer serum half-lives in primates

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4622737

The protection receptor for IgG catabolism is the beta2-microglobulin-containing neonatal intestinal transport receptor

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4622737

High throughput detection of antibody self-interaction by bio-layer interferometry

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4622737

A strategy for risk mitigation of antibodies with fast clearance.

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4622737

High throughput solution-based measurement of antibody-antigen affinity and epitope binning

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4622737

Rapid analysis of antibody self-association in complex mixtures using immunogold conjugates.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4622737

Reduced elimination of IgG antibodies by engineering the variable region.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4622737

Importance of neonatal FcR in regulating the serum half-life of therapeutic proteins containing the Fc domain of human IgG1: a comparative study of the affinity of monoclonal antibodies and Fc-fusion proteins to human neonatal FcR.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4622737

Properties of human IgG1s engineered for enhanced binding to the neonatal Fc receptor (FcRn).

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4622737

Preclinical pharmacokinetics, interspecies scaling, and tissue distribution of a humanized monoclonal antibody against vascular endothelial growth factor.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4622737

Cross-interaction chromatography: a rapid method to identify highly soluble monoclonal antibody candidates

22 September 2018

1 reference

12 December 2020

Monoclonal antibodies with identical Fc sequences can bind to FcRn differentially with pharmacokinetic consequences

1 reference

12 December 2020

Fc domain mediated self-association of an IgG1 monoclonal antibody under a low ionic strength condition

1 reference

12 December 2020

Plasmonic measurements of monoclonal antibody self-association using self-interaction nanoparticle spectroscopy

1 reference

12 December 2020

Half-life of polyreactive antibodies

1 reference

12 December 2020

10.1080/19420862.2015.1043503

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26047159%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

1 reference

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16 February 2020

PubMed publication ID

26047159

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26047159%20AND%20SRC:MED&resulttype=core&format=json