Immune responses to tuberculosis in developing countries: implications for new vaccines (Q36213975)

12 August 2017

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title

Immune responses to tuberculosis in developing countries: implications for new vaccines (English)

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12 August 2017

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3

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12 August 2017

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Keertan Dheda

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12 August 2017

Graham A W Rook

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12 August 2017

1 August 2005

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Nature Reviews Immunology

12 August 2017

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12 August 2017

5

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12 August 2017

8

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12 August 2017

661-667

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Variation in protection by BCG: implications of and for heterologous immunity

12 August 2017

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Severe mycobacterial and Salmonella infections in interleukin-12 receptor-deficient patients

21 January 2018

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Tuberculosis associated with infliximab, a tumor necrosis factor alpha-neutralizing agent

21 January 2018

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T cell-based tracking of multidrug resistant tuberculosis infection after brief exposure

21 January 2018

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Pathogenesis of tuberculosis: pathway to apical localization

21 January 2018

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Reduced immunopathology and mortality despite tissue persistence in a Mycobacterium tuberculosis mutant lacking alternative sigma factor, SigH

21 January 2018

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Mycobacterium tuberculosis WhiB3 interacts with RpoV to affect host survival but is dispensable for in vivo growth.

21 January 2018

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Failure to induce enhanced protection against tuberculosis by increasing T-cell-dependent interferon-gamma generation

21 January 2018

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Enhanced immunogenicity and protective efficacy against Mycobacterium tuberculosis of bacille Calmette-Guérin vaccine using mucosal administration and boosting with a recombinant modified vaccinia virus Ankara

21 January 2018

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Improved immunogenicity and protective efficacy of a tuberculosis DNA vaccine encoding Ag85 by protein boosting

21 January 2018

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Mycobacterium bovis BCG producing interleukin-18 increases antigen-specific gamma interferon production in mice.

21 January 2018

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Regulatory T cells: friend or foe in immunity to infection?

21 January 2018

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Antigen-specific and persistent tuberculin anergy in a cohort of pulmonary tuberculosis patients from rural Cambodia

21 January 2018

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Induction of T helper type 1-like regulatory cells that express Foxp3 and protect against airway hyper-reactivity

21 January 2018

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Sputum cytokine levels in patients with pulmonary tuberculosis as early markers of mycobacterial clearance.

21 January 2018

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Escape of malaria parasites from host immunity requires CD4+ CD25+ regulatory T cells

21 January 2018

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Geographic latitude and the efficacy of bacillus Calmette-Guérin vaccine

21 January 2018

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Mycobacterial antigens exacerbate disease manifestations in Mycobacterium tuberculosis-infected mice

21 January 2018

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Environmental mycobacteria in northern Malawi: implications for the epidemiology of tuberculosis and leprosy

21 January 2018

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Prospects for low dose BCG vaccination against tuberculosis

21 January 2018

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Do successful tuberculosis vaccines need to be immunoregulatory rather than merely Th1-boosting?

21 January 2018

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In situ study of abundant expression of proinflammatory chemokines and cytokines in pulmonary granulomas that develop in cynomolgus macaques experimentally infected with Mycobacterium tuberculosis

21 January 2018

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IL-4 in tuberculosis: implications for vaccine design

21 January 2018

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In vivo and in vitro studies of a novel cytokine, interleukin 4delta2, in pulmonary tuberculosis

21 January 2018

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Structural and functional properties of IL-4delta2, an alternative splice variant of human IL-4.

21 January 2018

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Cloning of interleukin-4 delta2 splice variant (IL-4delta2) in chimpanzee and cynomolgus macaque: phylogenetic analysis of delta2 splice variant appearance, and implications for the study of IL-4-driven immune processes

21 January 2018

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Increased expression of mRNA encoding interleukin (IL)-4 and its splice variant IL-4delta2 in cells from contacts of Mycobacterium tuberculosis, in the absence of in vitro stimulation.

21 January 2018

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Healthy individuals that control a latent infection with Mycobacterium tuberculosis express high levels of Th1 cytokines and the IL-4 antagonist IL-4delta2.

21 January 2018

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Mice incapable of making IL-4 or IL-10 display normal resistance to infection with Mycobacterium tuberculosis

21 January 2018

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Pulmonary tuberculosis in BALB/c mice with non-functional IL-4 genes: changes in the inflammatory effects of TNF-alpha and in the regulation of fibrosis

21 January 2018

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Interleukin-13 induces tissue fibrosis by selectively stimulating and activating transforming growth factor beta(1).

21 January 2018

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Absence of interleukin-4 determines less severe pulmonary paracoccidioidomycosis associated with impaired Th2 response

21 January 2018

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Alternative activation of macrophages

21 January 2018

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Inhibition of respiration by nitric oxide induces a Mycobacterium tuberculosis dormancy program

21 January 2018

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Increased Interleukin-4 production by CD8 and gammadelta T cells in health-care workers is associated with the subsequent development of active tuberculosis

21 January 2018

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Dendritic cells derived from BCG-infected precursors induce Th2-like immune response

21 January 2018

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Cross-linking of the mannose receptor on monocyte-derived dendritic cells activates an anti-inflammatory immunosuppressive program

21 January 2018

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Differential monocyte activation underlies strain-specific Mycobacterium tuberculosis pathogenesis

21 January 2018

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Il-4 influences apoptosis of mycobacterium-reactive lymphocytes in the presence of TNF-alpha.

21 January 2018

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Differential regulation of Th1 and Th2 cells by p91-110 and p21-40 peptides of the 16-kD alpha-crystallin antigen of Mycobacterium tuberculosis

21 January 2018

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Polarization of PPD-specific T-cell response of patients with tuberculosis from Th0 to Th1 profile after successful antimycobacterial therapy or in vitro conditioning with interferon-alpha or interleukin-12.

21 January 2018

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Immunotherapy with plasmid DNA encoding mycobacterial hsp65 in association with chemotherapy is a more rapid and efficient form of treatment for tuberculosis in mice.

21 January 2018

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Development of the Mycobacterium bovis BCG vaccine: review of the historical and biochemical evidence for a genealogical tree

21 January 2018

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A new vaccine against tuberculosis affords greater survival after challenge than the current vaccine in the guinea pig model of pulmonary tuberculosis

21 January 2018

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Recombinant modified vaccinia virus Ankara expressing antigen 85A boosts BCG-primed and naturally acquired antimycobacterial immunity in humans

21 January 2018

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Differential immune responses and protective efficacy induced by components of a tuberculosis polyprotein vaccine, Mtb72F, delivered as naked DNA or recombinant protein

21 January 2018

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Selecting the components for a safe and efficient tuberculosis subunit vaccine--recent progress and post-genomic insights

21 January 2018

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IL-10–producing and naturally occurring CD4+ Tregs: limiting collateral damage

21 January 2018

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Ex Vivo Characterization of Early Secretory Antigenic Target 6-Specific T Cells at Sites of Active Disease in Pleural Tuberculosis

21 January 2018

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Efficacy of BCG vaccine in the prevention of tuberculosis. Meta-analysis of the published literature

21 January 2018

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Alternative Splicing of Murine Interleukin-4 mRNA

21 January 2018

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Whither Mycobacterium vaccae—encore

21 January 2018

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Persistence of DNA from Mycobacterium tuberculosis in superficially normal lung tissue during latent infection

21 January 2018

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Interleukin-4 and Its Alternatively Spliced Variant (IL-4 δ 2) in Patients with Atopic Asthma

21 January 2018

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An IL-12-based vaccination method for preventing fibrosis induced by schistosome infection

21 January 2018

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Suppression of airway eosinophilia by killed Mycobacterium vaccae-induced allergen-specific regulatory T-cells

21 January 2018

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Immunological and pathological comparative analysis between experimental latent tuberculous infection and progressive pulmonary tuberculosis

21 January 2018

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Funding, advances invigorate TB fight

21 January 2018

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Efficacy of BCG vaccine in the prevention of tuberculosis. Meta-analysis of the published literature

31 March 2020

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Partial interferon-gamma receptor 1 deficiency in a child with tuberculoid bacillus Calmette-Guérin infection and a sibling with clinical tuberculosis

31 March 2020

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High frequencies of circulating IFN-γ-secreting CD8 cytotoxic T cells specific for a novel MHC class I-restrictedMycobacterium tuberculosis epitope inM. tuberculosis-infected subjects without disease

31 March 2020

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A DNA prime-live vaccine boost strategy in mice can augment IFN-gamma responses to mycobacterial antigens but does not increase the protective efficacy of two attenuated strains of Mycobacterium bovis against bovine tuberculosis

31 March 2020

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IL-10-producing and naturally occurring CD4+ Tregs: limiting collateral damage

31 March 2020

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IL-10-producing T cells suppress immune responses in anergic tuberculosis patients

31 March 2020

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Detection of low-frequency antigen-specific IL-10-producing CD4(+) T cells via ELISPOT in PBMC: cognate vs. nonspecific production of the cytokine

31 March 2020

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CD4+ T Cell Clones Producing both Interferon-γ and Interleukin-10 Predominate in Bronchoalveolar Lavages of Active Pulmonary Tuberculosis Patients

31 March 2020

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Validation of housekeeping genes for normalizing RNA expression in real-time PCR.

31 March 2020

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Contribution of Th1 and Th2 cells to protection and pathology in experimental models of granulomatous lung disease

31 March 2020

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IL-4-regulated enteropathy in an intestinal nematode infection

31 March 2020

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Mechanism of suppression of nitric oxide synthase expression by interleukin-4 in primary mouse macrophages

31 March 2020

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The success and failure of BCG - implications for a novel tuberculosis vaccine

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRI1666

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12 August 2017

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PubMed ID

16056257