Latent HIV-1 is activated by exosomes from cells infected with either replication-competent or defective HIV-1. (Q36217786)

12 August 2017

Latent HIV-1 is activated by exosomes from cells infected with either replication-competent or defective HIV-1. (English)

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12 August 2017

1

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5 June 2020

Francesco Manfredi

3

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5 June 2020

Eleonora Olivetta

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5 June 2020

Maurizio Federico

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5 June 2020

author name string

Simona Anticoli

2

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5 June 2020

Chiara Chiozzini

4

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publication date

26 October 2015

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12 August 2017

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5 June 2020

volume

12

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5 June 2020

page(s)

87

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https://scigraph.springernature.com/pub.10.1186/s12977-015-0216-y

5 June 2020

exact match

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cites work

Exosomes from human immunodeficiency virus type 1 (HIV-1)-infected cells license quiescent CD4+ T lymphocytes to replicate HIV-1 through a Nef- and ADAM17-dependent mechanism.

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Cell activation and HIV-1 replication in unstimulated CD4+ T lymphocytes ingesting exosomes from cells expressing defective HIV-1.

1 October 2017

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An in-depth comparison of latent HIV-1 reactivation in multiple cell model systems and resting CD4+ T cells from aviremic patients

1 October 2017

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Comparative analysis of measures of viral reservoirs in HIV-1 eradication studies

1 October 2017

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HIV Nef, paxillin, and Pak1/2 regulate activation and secretion of TACE/ADAM10 proteases

1 October 2017

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Biochemical and biologic characterization of exosomes and microvesicles as facilitators of HIV-1 infection in macrophages

1 October 2017

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Sphingolipid-modulated exosome secretion promotes clearance of amyloid-β by microglia

1 October 2017

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A flexible model of HIV-1 latency permitting evaluation of many primary CD4 T-cell reservoirs

1 October 2017

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1 October 2017

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Competitive interactions of cancer cells and normal cells via secretory microRNAs

1 October 2017

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Intercellular nanovesicle-mediated microRNA transfer: a mechanism of environmental modulation of hepatocellular cancer cell growth

1 October 2017

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1 October 2017

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Studies of HIV-1 latency in an ex vivo model that uses primary central memory T cells

1 October 2017

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HIV-1 is budded from CD4+ T lymphocytes independently of exosomes

1 October 2017

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Exosome release of β-catenin: a novel mechanism that antagonizes Wnt signaling

1 October 2017

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Exosomes: extracellular organelles important in intercellular communication

1 October 2017

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Secretory mechanisms and intercellular transfer of microRNAs in living cells

1 October 2017

1 reference

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ADAM-17: the enzyme that does it all.

1 October 2017

1 reference

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HIV Nef is secreted in exosomes and triggers apoptosis in bystander CD4+ T cells

1 October 2017

1 reference

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Small-molecule screening using a human primary cell model of HIV latency identifies compounds that reverse latency without cellular activation

1 October 2017

1 reference

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HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation

1 October 2017

1 reference

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Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers

1 October 2017

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Human immunodeficiency virus type 1 Nef induces programmed death 1 expression through a p38 mitogen-activated protein kinase-dependent mechanism

1 October 2017

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Discrimination between exosomes and HIV-1: purification of both vesicles from cell-free supernatants

1 October 2017

1 reference

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Valproic acid without intensified antiviral therapy has limited impact on persistent HIV infection of resting CD4+ T cells

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4623921

Low-level viremia persists for at least 7 years in patients on suppressive antiretroviral therapy

1 October 2017

1 reference

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Ceramide triggers budding of exosome vesicles into multivesicular endosomes

1 October 2017

1 reference

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Isolation and characterization of exosomes from cell culture supernatants and biological fluids

1 October 2017

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Higher-order oligomerization targets plasma membrane proteins and HIV gag to exosomes

1 October 2017

1 reference

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Exosomes and HIV Gag bud from endosome-like domains of the T cell plasma membrane

1 October 2017

1 reference

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Human immunodeficiency virus type 1 can establish latent infection in resting CD4+ T cells in the absence of activating stimuli

1 October 2017

1 reference

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HIV reproducibly establishes a latent infection after acute infection of T cells in vitro.

1 October 2017

1 reference

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Human immunodeficiency virus type 1 DNA sequences genetically damaged by hypermutation are often abundant in patient peripheral blood mononuclear cells and may be generated during near-simultaneous infection and activation of CD4(+) T cells

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4623921

Design and use of an inducibly activated human immunodeficiency virus type 1 Nef to study immune modulation

1 October 2017

1 reference

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Residual HIV-RNA levels persist for up to 2.5 years in peripheral blood mononuclear cells of patients on potent antiretroviral therapy

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4623921

Human immunodeficiency virus type 1 Nef protein sensitizes CD4(+) T lymphoid cells to apoptosis via functional upregulation of the CD95/CD95 ligand pathway.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4623921

Mutations in the tat gene are responsible for human immunodeficiency virus type 1 postintegration latency in the U1 cell line

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4623921

Recovery of replication-competent HIV despite prolonged suppression of plasma viremia

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4623921

Accumulation of defective viral genomes in peripheral blood mononuclear cells of human immunodeficiency virus type 1-infected individuals.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4623921

Establishment of a stable, inducible form of human immunodeficiency virus type 1 DNA in quiescent CD4 lymphocytes in vitro

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4623921

Tumor necrosis factor alpha induces expression of human immunodeficiency virus in a chronically infected T-cell clone

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4623921

AIDS/HIV. Rekindled HIV infection

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4623921

Apoptosis enhancement by the HIV-1 Nef protein.

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4623921

Cytokine-induced expression of HIV-1 in a chronically infected promonocyte cell line.

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4623921

Biologic and molecular characterization of producer and nonproducer clones from HUT-78 cells infected with a patient HIV isolate.

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4623921

Replication-competent noninduced proviruses in the latent reservoir increase barrier to HIV-1 cure.

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4623921

HIV-1 genome is often defective in PBMCs and rectal tissues after long-term HAART as a result of APOBEC3 editing and correlates with the size of reservoirs.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4623921

CCR7 ligands CCL19 and CCL21 increase permissiveness of resting memory CD4+ T cells to HIV-1 infection: a novel model of HIV-1 latency.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4623921

Fluorescent substrates for the proteinases ADAM17, ADAM10, ADAM8, and ADAM12 useful for high-throughput inhibitor screening.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4623921

HIV-1 Nef regulates the release of superoxide anions from human macrophages.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4623921

Long-term follow-up studies confirm the stability of the latent reservoir for HIV-1 in resting CD4+ T cells.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4623921

Selective enrichment of tetraspan proteins on the internal vesicles of multivesicular endosomes and on exosomes secreted by human B-lymphocytes.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4623921

Characterization of a promonocyte clone chronically infected with HIV and inducible by 13-phorbol-12-myristate acetate.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4623921

The ESCRT pathway and HIV-1 budding

22 September 2018

1 reference

12 December 2020

Massive Secretion by T Cells Is Caused by HIV Nef in Infected Cells and by Nef Transfer to Bystander Cells

1 reference

12 December 2020

Residual HIV-1 RNA in blood plasma of patients taking suppressive highly active antiretroviral therapy

1 reference

12 December 2020

Exosomes released during reticulocyte maturation bind to fibronectin via integrin alpha4beta1

1 reference

12 December 2020

HIV-1 Nef activates STAT1 in human monocytes/macrophages through the release of soluble factors

1 reference

12 December 2020

Decay-accelerating factor (CD55) and membrane inhibitor of reactive lysis (CD59) are released within exosomes during In vitro maturation of reticulocytes

1 reference

12 December 2020

10.1186/S12977-015-0216-Y

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DOI

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5 June 2020

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5 June 2020

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