In vivo analysis of the role of aberrant histone deacetylase recruitment and RAR alpha blockade in the pathogenesis of acute promyelocytic leukemia. (Q36228502)

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English	In vivo analysis of the role of aberrant histone deacetylase recruitment and RAR alpha blockade in the pathogenesis of acute promyelocytic leukemia.	scientific article

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18 January 2020

In vivo analysis of the role of aberrant histone deacetylase recruitment and RAR alpha blockade in the pathogenesis of acute promyelocytic leukemia (English)

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18 January 2020

Hiromichi Matsushita

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18 January 2020

Pier Paolo Scaglioni

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18 January 2020

Eduardo Magalhães Rego

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Pier Paolo Pandolfi

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Pier Paolo Pandolfi

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Hayato Miyachi

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Samia M Majid

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Mantu Bhaumik

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Lu Fan Cai

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18 January 2020

Akira Kakizuka

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18 January 2020

Wilson H Miller

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18 January 2020

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20 March 2006

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18 January 2020

Journal of Experimental Medicine

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18 January 2020

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18 January 2020

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18 January 2020

821-828

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18 January 2020

PML-RARA-RXR oligomers mediate retinoid and rexinoid/cAMP cross-talk in acute promyelocytic leukemia cell differentiation

1 reference

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1 October 2017

Biological roles and mechanistic actions of co-repressor complexes

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1 October 2017

Methyltransferase recruitment and DNA hypermethylation of target promoters by an oncogenic transcription factor

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1 October 2017

Translocations of the RARalpha gene in acute promyelocytic leukemia

1 reference

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1 October 2017

Function of RARalpha during the maturation of neutrophils

1 reference

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1 October 2017

DNA methylation, chromatin inheritance, and cancer

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1 October 2017

Inhibition of transformed cell growth and induction of cellular differentiation by pyroxamide, an inhibitor of histone deacetylase

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1 October 2017

DNA recognition by the aberrant retinoic acid receptors implicated in human acute promyelocytic leukemia

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1 October 2017

Positive and negative regulation of granulopoiesis by endogenous RARalpha

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1 October 2017

Role of promyelocytic leukemia (PML) protein in tumor suppression

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1 October 2017

Acquired, nonrandom chromosomal abnormalities associated with the development of acute promyelocytic leukemia in transgenic mice

1 reference

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1 October 2017

Retinoic acid (RA) and As2O3 treatment in transgenic models of acute promyelocytic leukemia (APL) unravel the distinct nature of the leukemogenic process induced by the PML-RARalpha and PLZF-RARalpha oncoproteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118271

1 October 2017

c-Myb acetylation at the carboxyl-terminal conserved domain by transcriptional co-activator p300.

1 reference

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1 October 2017

Distinct leukemia phenotypes in transgenic mice and different corepressor interactions generated by promyelocytic leukemia variant fusion genes PLZF-RARalpha and NPM-RARalpha

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118271

1 October 2017

Deconstructing a disease: RARalpha, its fusion partners, and their roles in the pathogenesis of acute promyelocytic leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118271

1 October 2017

A role for histone deacetylase activity in HDAC1-mediated transcriptional repression

1 reference

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1 October 2017

Fusion proteins of the retinoic acid receptor-alpha recruit histone deacetylase in promyelocytic leukaemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118271

1 October 2017

Role of the histone deacetylase complex in acute promyelocytic leukaemia

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118271

1 October 2017

Opposite effects of the acute promyelocytic leukemia PML-retinoic acid receptor alpha (RAR alpha) and PLZF-RAR alpha fusion proteins on retinoic acid signalling.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118271

1 October 2017

A retinoid-resistant acute promyelocytic leukemia subclone expresses a dominant negative PML-RAR alpha mutation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118271

1 October 2017

Acute leukemia with promyelocytic features in PML/RARalpha transgenic mice

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1 October 2017

Effects on differentiation by the promyelocytic leukemia PML/RARalpha protein depend on the fusion of the PML protein dimerization and RARalpha DNA binding domains

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118271

1 October 2017

PMLRAR homodimers: distinct DNA binding properties and heteromeric interactions with RXR

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1 October 2017

RARs and RXRs: evidence for two autonomous transactivation functions (AF-1 and AF-2) and heterodimerization in vivo

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Myeloid leukemia with promyelocytic features in transgenic mice expressing hCG-NuMA-RARalpha

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29 June 2018

Acquisition of oncogenic potential by RAR chimeras in acute promyelocytic leukemia through formation of homodimers.

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29 June 2018

The t(5;17) acute promyelocytic leukemia fusion protein NPM-RAR interacts with co-repressor and co-activator proteins and exhibits both positive and negative transcriptional properties.

1 reference

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29 June 2018

Distinct interactions of PML-RARalpha and PLZF-RARalpha with co-repressors determine differential responses to RA in APL.

1 reference

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21 January 2018

Oligomerization of RAR and AML1 transcription factors as a novel mechanism of oncogenic activation.

1 reference

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21 January 2018

Recurring chromosomal abnormalities in leukemia in PML-RARA transgenic mice parallel human acute promyelocytic leukemia.

1 reference

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21 January 2018

Altered ligand binding and transcriptional regulation by mutations in the PML/RARalpha ligand-binding domain arising in retinoic acid-resistant patients with acute promyelocytic leukemia.

1 reference

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22 September 2018

Inhibition of skin development by targeted expression of a dominant-negative retinoic acid receptor

1 reference

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21 January 2018

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18 January 2020

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18 January 2020

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18 January 2020

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