APE1- and APE2-dependent DNA breaks in immunoglobulin class switch recombination. (Q36229211)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18025127%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

title

APE1- and APE2-dependent DNA breaks in immunoglobulin class switch recombination (English)

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27 December 2019

1

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27 December 2019

Yusaku Nakabeppu

4

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27 December 2019

Carol E. Schrader

7

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27 December 2019

author name string

Erin K Linehan

2

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27 December 2019

Daisuke Tsuchimoto

3

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27 December 2019

Phyllis R Strauss

5

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27 December 2019

Janet Stavnezer

6

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27 December 2019

language of work or name

English

0 references

publication date

19 November 2007

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Journal of Experimental Medicine

27 December 2019

published in

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27 December 2019

volume

204

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27 December 2019

issue

12

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27 December 2019

page(s)

3017-3026

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DNA polymerase beta is able to repair breaks in switch regions and plays an inhibitory role during immunoglobulin class switch recombination

27 December 2019

cites work

1 reference

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Human Xip1 (C2orf13) is a novel regulator of cellular responses to DNA strand breaks

1 October 2017

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A novel human AP endonuclease with conserved zinc-finger-like motifs involved in DNA strand break responses

1 October 2017

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APLF (C2orf13) is a novel human protein involved in the cellular response to chromosomal DNA strand breaks

1 October 2017

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Antibody class switching mediated by yeast endonuclease-generated DNA breaks.

1 October 2017

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The chemical stability of abasic RNA compared to abasic DNA.

1 October 2017

1 reference

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Human Ape2 protein has a 3'-5' exonuclease activity that acts preferentially on mismatched base pairs

1 October 2017

1 reference

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Isolation of a small molecule inhibitor of DNA base excision repair.

1 October 2017

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Inducible DNA breaks in Ig S regions are dependent on AID and UNG

1 October 2017

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Two essential but distinct functions of the mammalian abasic endonuclease

1 October 2017

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A vital role for Ape1/Ref1 protein in repairing spontaneous DNA damage in human cells.

1 October 2017

1 reference

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Genomic instability, endoreduplication, and diminished Ig class-switch recombination in B cells lacking Nbs1.

1 October 2017

1 reference

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Nibrin functions in Ig class-switch recombination

1 October 2017

1 reference

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Mismatch recognition and uracil excision provide complementary paths to both Ig switching and the A/T-focused phase of somatic mutation

1 October 2017

1 reference

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Class-switch recombination: interplay of transcription, DNA deamination and DNA repair

1 October 2017

1 reference

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Mechanisms of human DNA repair: an update

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118529

Mutations occur in the Ig Smu region but rarely in Sgamma regions prior to class switch recombination

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118529

AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118529

Mechanism and control of class-switch recombination

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118529

Base excision repair intermediates as topoisomerase II poisons

1 October 2017

1 reference

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Heterozygosity for the mouse Apex gene results in phenotypes associated with oxidative stress.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118529

Human APE2 protein is mostly localized in the nuclei and to some extent in the mitochondria, while nuclear APE2 is partly associated with proliferating cell nuclear antigen

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118529

Genome maintenance mechanisms for preventing cancer

1 October 2017

1 reference

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Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2)

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118529

Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118529

A method for detecting abasic sites in living cells: age-dependent changes in base excision repair

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118529

Reduced isotype switching in splenic B cells from mice deficient in mismatch repair enzymes

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118529

Identification of redox/repair protein Ref-1 as a potent activator of p53

1 October 2017

1 reference

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AP-1 transcriptional activity is regulated by a direct association between thioredoxin and Ref-1

1 October 2017

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Substrate binding by human apurinic/apyrimidinic endonuclease indicates a Briggs-Haldane mechanism

1 October 2017

1 reference

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Negative regulation of the major human AP-endonuclease, a multifunctional protein

1 October 2017

1 reference

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The redox/DNA repair protein, Ref-1, is essential for early embryonic development in mice.

1 October 2017

1 reference

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Repair of oxidative damage to DNA: enzymology and biology

1 October 2017

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Redox activation of Fos-Jun DNA binding activity is mediated by a DNA repair enzyme

1 October 2017

1 reference

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Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient mice

1 October 2017

1 reference

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Rate of chain breakage at apurinic sites in double-stranded deoxyribonucleic acid

29 June 2018

1 reference

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Activation-induced cytidine deaminase-dependent DNA breaks in class switch recombination occur during G1 phase of the cell cycle and depend upon mismatch repair

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118529

Different organization of base excision repair of uracil in DNA in nuclei and mitochondria and selective upregulation of mitochondrial uracil-DNA glycosylase after oxidative stress

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118529

Transcription arrest at an abasic site in the transcribed strand of template DNA.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118529

Endonucleolytic function of MutLalpha in human mismatch repair.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118529

Mismatch repair converts AID-instigated nicks to double-strand breaks for antibody class-switch recombination

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118529

MRE11/RAD50 cleaves DNA in the AID/UNG-dependent pathway of immunoglobulin gene diversification

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118529

Host cell reactivation of plasmids containing oxidative DNA lesions is defective in Cockayne syndrome but normal in UV-sensitive syndrome fibroblasts

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118529

Growth retardation and dyslymphopoiesis accompanied by G2/M arrest in APEX2-null mice.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118529

Apurinic/apyrimidinic endonuclease (APE/REF-1) haploinsufficient mice display tissue-specific differences in DNA polymerase beta-dependent base excision repair.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118529

Delineation of the role of the Mre11 complex in class switch recombination

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118529

Human uracil-DNA glycosylase deficiency associated with profoundly impaired immunoglobulin class-switch recombination

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118529

Determinants in nuclease specificity of Ape1 and Ape2, human homologues of Escherichia coli exonuclease III.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118529

Redox factor 1 (Ref-1) enhances specific DNA binding of p53 by promoting p53 tetramerization

22 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18025127

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Second human protein with homology to the Escherichia coli abasic endonuclease exonuclease III

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18025127

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1084/JEM.20071289

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18025127%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18025127%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

PubMed publication ID

18025127

1 reference