Mouse lipin-1 and lipin-2 cooperate to maintain glycerolipid homeostasis in liver and aging cerebellum. (Q36236228)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22908270%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

title

Mouse lipin-1 and lipin-2 cooperate to maintain glycerolipid homeostasis in liver and aging cerebellum (English)

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1

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Laurent Vergnes

5

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Stephen G. Young

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Karen Reue

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3

Peixiang Zhang

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4

Lauren S Csaki

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Loren G Fong

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Jimmy Donkor

2

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Jessica M Lee

6

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Jay Dewald

7

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David N Brindley

8

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Elisa Atti

9

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Sotirios Tetradis

10

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Yuko Yoshinaga

11

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11 February 2020

Pieter J De Jong

12

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11 February 2020

language of work or name

English

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publication date

20 August 2012

1 reference

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Proceedings of the National Academy of Sciences of the United States of America

11 February 2020

published in

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volume

109

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issue

37

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page(s)

E2486-95

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Glycerolipid signals alter mTOR complex 2 (mTORC2) to diminish insulin signaling

11 February 2020

cites work

1 reference

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Lipin-1 phosphatidic phosphatase activity modulates phosphatidate levels to promote peroxisome proliferator-activated receptor γ (PPARγ) gene expression during adipogenesis

1 October 2017

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Relationship of glucose and oleate metabolism to cardiac function in lipin-1 deficient (fld) mice

1 October 2017

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Lysophosphatidic acid activates peroxisome proliferator activated receptor-γ in CHO cells that over-express glycerol 3-phosphate acyltransferase-1

1 October 2017

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Dual function lipin proteins and glycerolipid metabolism

1 October 2017

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Heart-type fatty acid-binding protein is essential for efficient brown adipose tissue fatty acid oxidation and cold tolerance.

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Lipin proteins form homo- and hetero-oligomers

1 October 2017

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1 October 2017

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Lipins: multifunctional lipid metabolism proteins

1 October 2017

1 reference

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Lipin 1 represses NFATc4 transcriptional activity in adipocytes to inhibit secretion of inflammatory factors

1 October 2017

1 reference

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A conserved serine residue is required for the phosphatidate phosphatase activity but not the transcriptional coactivator functions of lipin-1 and lipin-2

1 October 2017

1 reference

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Phosphatidic acid phosphohydrolase in the regulation of inflammatory signaling

1 October 2017

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Biochemistry, physiology, and genetics of GPAT, AGPAT, and lipin enzymes in triglyceride synthesis

1 October 2017

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Phosphatidate degradation: phosphatidate phosphatases (lipins) and lipid phosphate phosphatases

1 October 2017

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Lipin 2 is a liver-enriched phosphatidate phosphohydrolase enzyme that is dynamically regulated by fasting and obesity in mice

1 October 2017

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Metabolic syndrome: from epidemiology to systems biology

1 October 2017

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Mutations in LPIN1 cause recurrent acute myoglobinuria in childhood.

1 October 2017

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Phosphatidic acid phosphatase, a key enzyme in the regulation of lipid synthesis

1 October 2017

1 reference

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Thematic Review Series: Glycerolipids. Multiple roles for lipins/phosphatidate phosphatase enzymes in lipid metabolism

1 October 2017

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Temporal and spatial regulation of the phosphatidate phosphatases lipin 1 and 2

1 October 2017

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Phosphatidic acid mediates demyelination in Lpin1 mutant mice

1 October 2017

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Regulation of lipin-1 gene expression by glucocorticoids during adipogenesis

1 October 2017

1 reference

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Adipose tissue lipin-1 expression is correlated with peroxisome proliferator-activated receptor alpha gene expression and insulin sensitivity in healthy young men.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3443145

A splice site mutation confirms the role of LPIN2 in Majeed syndrome.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3443145

Diagnosis and management of early- and late-onset cerebellar ataxia

1 October 2017

1 reference

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Three mammalian lipins act as phosphatidate phosphatases with distinct tissue expression patterns

1 October 2017

1 reference

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Insulin controls subcellular localization and multisite phosphorylation of the phosphatidic acid phosphatase, lipin 1.

1 October 2017

1 reference

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Lipin 1 is an inducible amplifier of the hepatic PGC-1alpha/PPARalpha regulatory pathway

1 October 2017

1 reference

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Quantitative profiling of polar glycerolipid species from organs of wild-type Arabidopsis and a phospholipase Dalpha1 knockout mutant

1 October 2017

1 reference

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Agpat6 deficiency causes subdermal lipodystrophy and resistance to obesity

1 October 2017

1 reference

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Gene targeting using a promoterless gene trap vector ("targeted trapping") is an efficient method to mutate a large fraction of genes.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3443145

Homozygous mutations in LPIN2 are responsible for the syndrome of chronic recurrent multifocal osteomyelitis and congenital dyserythropoietic anaemia (Majeed syndrome).

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3443145

Cerebellar control of balance and locomotion

1 October 2017

1 reference

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Enzymes of triacylglycerol synthesis and their regulation

1 October 2017

1 reference

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A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3443145

Age-associated changes in central nervous system glycerolipid composition and metabolism

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3443145

The syndrome of chronic recurrent multifocal osteomyelitis and congenital dyserythropoietic anaemia. Report of a new family and a review

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3443145

Mutant mice as a model for cerebellar ataxia

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3443145

Lipodystrophy in the fld mouse results from mutation of a new gene encoding a nuclear protein, lipin

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3443145

Adipose tissue deficiency, glucose intolerance, and increased atherosclerosis result from mutation in the mouse fatty liver dystrophy (fld) gene.

1 October 2017

1 reference

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Behavioral and functional analysis of mouse phenotype: SHIRPA, a proposed protocol for comprehensive phenotype assessment

1 October 2017

1 reference

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Congenital dyserythropoietic anemia and chronic recurrent multifocal osteomyelitis in three related children and the association with Sweet syndrome in two siblings

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3443145

Endoplasmic reticulum stress promotes LIPIN2-dependent hepatic insulin resistance

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3443145

The level and compartmentalization of phosphatidate phosphatase-1 (lipin-1) control the assembly and secretion of hepatic VLDL.

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3443145

Lipin expression preceding peroxisome proliferator-activated receptor-gamma is critical for adipogenesis in vivo and in vitro.

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3443145

LPIN1 gene mutations: a major cause of severe rhabdomyolysis in early childhood

29 June 2018

1 reference

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Environmental enrichment slows disease progression in R6/2 Huntington's disease mice

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3443145

Aging promotes a different phosphatidic acid utilization in cytosolic and microsomal fractions from brain and liver

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3443145

Profiling Membrane Lipids in Plant Stress Responses

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3443145

Phospholipase D and phosphatidate phosphohydrolase activities in rat cerebellum during aging

5 December 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22908270

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Quantification of Bone Microarchitecture with the Structure Model Index

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22908270

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.1205221109

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22908270%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22908270%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22908270%20AND%20SRC:MED&resulttype=core&format=json