Structural basis of interaction between urokinase-type plasminogen activator and its receptor (Q36237711)

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30 December 2019

title

Structural basis of interaction between urokinase-type plasminogen activator and its receptor (English)

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30 December 2019

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1

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author name string

Graham Parry

2

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30 December 2019

Jennifer Callahan

3

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David E Shaw

4

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30 December 2019

Alice Kuo

5

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30 December 2019

Khalil Bdeir

6

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30 December 2019

Douglas B Cines

7

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Andrew Mazar

8

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Jacek Lubkowski

9

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language of work or name

English

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publication date

26 August 2006

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Journal of Molecular Biology

30 December 2019

published in

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volume

363

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issue

2

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page(s)

482-495

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Structure of human urokinase plasminogen activator in complex with its receptor

30 December 2019

cites work

1 reference

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Urokinase-induced signaling in human vascular smooth muscle cells is mediated by PDGFR-beta

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Cross-talk between fMLP and vitronectin receptors triggered by urokinase receptor-derived SRSRY peptide

1 October 2017

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Domain 2 of the urokinase receptor contains an integrin-interacting epitope with intrinsic signaling activity: generation of a new integrin inhibitor

1 October 2017

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Crystal structure of the human urokinase plasminogen activator receptor bound to an antagonist peptide

1 October 2017

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1 October 2017

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1 October 2017

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Characterization of low-glycosylated forms of soluble human urokinase receptor expressed in Drosophila Schneider 2 cells after deletion of glycosylation-sites.

1 October 2017

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Proteolytic regulation of the urokinase receptor/CD87 on monocytic cells by neutrophil elastase and cathepsin G

1 October 2017

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Molecular and functional interdependence of the urokinase-type plasminogen activator system with integrins

1 October 2017

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Sequences within domain II of the urokinase receptor critical for differential ligand recognition

1 October 2017

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Metalloproteases cleave the urokinase-type plasminogen activator receptor in the D1-D2 linker region and expose epitopes not present in the intact soluble receptor

1 October 2017

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The fibrinolytic receptor for urokinase activates the G protein-coupled chemotactic receptor FPRL1/LXA4R.

1 October 2017

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Peptide-derived antagonists of the urokinase receptor. affinity maturation by combinatorial chemistry, identification of functional epitopes, and inhibitory effect on cancer cell intravasation

1 October 2017

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The role of the plasminogen activation system in angiogenesis and metastasis

1 October 2017

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Direct binding of occupied urokinase receptor (uPAR) to LDL receptor-related protein is required for endocytosis of uPAR and regulation of cell surface urokinase activity

1 October 2017

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Identification of a urokinase receptor-integrin interaction site. Promiscuous regulator of integrin function

1 October 2017

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Mapping part of the functional epitope for ligand binding on the receptor for urokinase-type plasminogen activator by site-directed mutagenesis

1 October 2017

1 reference

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Cleavage of urokinase receptor regulates its interaction with integrins in thyroid cells.

1 October 2017

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Efficient anisotropic refinement of macromolecular structures using FFT

1 October 2017

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Further additions to MolScript version 1.4, including reading and contouring of electron-density maps

1 October 2017

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Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

1 October 2017

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Urokinase receptor (CD87) regulates leukocyte recruitment via beta 2 integrins in vivo.

1 October 2017

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Glycosylation profile of a recombinant urokinase-type plasminogen activator receptor expressed in Chinese hamster ovary cells

1 October 2017

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Binding of high molecular weight kininogen to human endothelial cells is mediated via a site within domains 2 and 3 of the urokinase receptor

1 October 2017

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1 October 2017

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Proteolytic cleavage of the urokinase receptor substitutes for the agonist-induced chemotactic effect

1 October 2017

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N-linked glycosylation of the ligand-binding domain of the human urokinase receptor contributes to the affinity for its ligand

1 October 2017

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Solution structure of the amino-terminal fragment of urokinase-type plasminogen activator

1 October 2017

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The structure of the urokinase-type plasminogen activator receptor gene

1 October 2017

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Chemical modification of the urokinase-type plasminogen activator and its receptor using tetranitromethane. Evidence for the involvement of specific tyrosine residues in both molecules during receptor-ligand interaction

1 October 2017

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The human receptor for urokinase plasminogen activator. NH2-terminal amino acid sequence and glycosylation variants

1 October 2017

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Three dimensional structure of erabutoxin b neurotoxic protein: inhibitor of acetylcholine receptor

1 October 2017

1 reference

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Systematic mutational analysis of the receptor-binding region of the human urokinase-type plasminogen activator.

1 October 2017

1 reference

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Specific binding of urinary-type plasminogen activator (u-PA) to vitronectin and its role in mediating u-PA-dependent adhesion of U937 cells

29 June 2018

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The receptor-binding sequence of urokinase. A biological function for the growth-factor module of proteases

29 June 2018

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The kringle stabilizes urokinase binding to the urokinase receptor

29 June 2018

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Plasmin-dependent elimination of the growth-factor-like domain in urokinase causes its rapid cellular uptake and degradation.

22 September 2018

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Cellular glycosylphosphatidylinositol-specific phospholipase D regulates urokinase receptor shedding and cell surface expression

22 September 2018

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12 December 2020

A region in domain II of the urokinase receptor required for urokinase binding

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12 December 2020

Urokinase regulates vitronectin binding by controlling urokinase receptor oligomerization

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12 December 2020

Domain structure and interactions of recombinant urokinase-type plasminogen activator

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12 December 2020

The urokinase receptor and the regulation of cell proliferation

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12 December 2020

Processing of X-ray diffraction data collected in oscillation mode

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12 December 2020

Identification of the urokinase receptor as an adhesion receptor for vitronectin

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12 December 2020

Physical association of complement receptor type 3 and urokinase-type plasminogen activator receptor in neutrophil membranes

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12 December 2020

NMR studies of the dynamics of the multidomain protein urokinase-type plasminogen activator

1 reference

12 December 2020

Mac-1 (CD11b/CD18) and the urokinase receptor (CD87) form a functional unit on monocytic cells

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12 December 2020

Soluble human urokinase receptor is composed of two active units

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12 December 2020

Cell-surface acceleration of urokinase-catalyzed receptor cleavage

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12 December 2020

The intact urokinase receptor is required for efficient vitronectin binding: receptor cleavage prevents ligand interaction

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12 December 2020

Binding of human urokinase-type plasminogen activator to its receptor: residues involved in species specificity and binding

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12 December 2020

10.1016/J.JMB.2006.08.063

Identifiers

DOI

1 reference

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30 December 2019

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30 December 2019

PubMed publication ID

16979660

1 reference