Increased type II collagen cleavage by cathepsin K and collagenase activities with aging and osteoarthritis in human articular cartilage (Q36245974)

13 August 2017

Increased type II collagen cleavage by cathepsin K and collagenase activities with aging and osteoarthritis in human articular cartilage (English)

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13 August 2017

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Valeria M Dejica

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13 August 2017

John S Mort

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13 August 2017

Sheila Laverty

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13 August 2017

John Antoniou

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13 August 2017

David J Zukor

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13 August 2017

Michael Tanzer

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13 August 2017

A Robin Poole

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13 August 2017

14 May 2012

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Arthritis Research and Therapy

13 August 2017

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13 August 2017

14

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13 August 2017

3

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13 August 2017

R113

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https://scigraph.springernature.com/pub.10.1186/ar3839

13 August 2017

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cites work

Events in articular chondrocytes with aging

1 reference

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1 October 2017

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Cleavage of type II collagen by cathepsin K in human osteoarthritic cartilage

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446490

Osteoarthritis and cartilage: the role of cytokines

1 October 2017

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Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilage

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446490

Damage to type II collagen in aging and osteoarthritis starts at the articular surface, originates around chondrocytes, and extends into the cartilage with progressive degeneration

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446490

Independent expression of fibril-forming collagens I, II, and III in chondrocytes of human osteoarthritic cartilage

1 October 2017

1 reference

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Development of criteria for the classification and reporting of osteoarthritis. Classification of osteoarthritis of the knee. Diagnostic and Therapeutic Criteria Committee of the American Rheumatism Association

1 October 2017

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Cleavage of type II and III collagens with mammalian collagenase: site of cleavage and primary structure at the amino-terminal portion of the smaller fragment released from both collagens

1 October 2017

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Review of articular cartilage collagen research

1 October 2017

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Acidic cysteine endoproteinase cathepsin K in the degeneration of the superficial articular hyaline cartilage in osteoarthritis.

1 October 2017

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The tensile properties of the cartilage of human femoral condyles related to the content of collagen and glycosaminoglycans.

29 June 2018

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Protective effects of a cathepsin K inhibitor, SB-553484, in the canine partial medial meniscectomy model of osteoarthritis.

29 June 2018

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Inhibition of cathepsin K reduces bone erosion, cartilage degradation and inflammation evoked by collagen-induced arthritis in mice

21 January 2018

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The assessment of cartilage degradation in vivo: development of an immunoassay for the measurement in body fluids of type II collagen cleaved by collagenases

21 January 2018

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Expression of collagen type I and type II in consecutive stages of human osteoarthritis.

21 January 2018

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Role of interleukin-1 and tumor necrosis factor alpha in matrix degradation of human osteoarthritic cartilage.

21 January 2018

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Evidence to suggest that cathepsin K degrades articular cartilage in naturally occurring equine osteoarthritis

21 January 2018

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21 January 2018

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Accumulation of advanced glycation endproducts reduces chondrocyte-mediated extracellular matrix turnover in human articular cartilage

21 January 2018

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The release of crosslinked peptides from type II collagen into human synovial fluid is increased soon after joint injury and in osteoarthritis

21 January 2018

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Human cathepsin K cleaves native type I and II collagens at the N-terminal end of the triple helix

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446490

Copper-H2O2 oxidation strikingly improves silver intensification of the nickel-diaminobenzidine (Ni-DAB) end-product of the peroxidase reaction

22 September 2018

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12 December 2020

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12 December 2020

The collagenolytic activity of cathepsin K is unique among mammalian proteinases

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12 December 2020

Urinary type II collagen helical peptide (HELIX-II) as a new biochemical marker of cartilage degradation in patients with osteoarthritis and rheumatoid arthritis

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12 December 2020

Collagen and proteoglycan turnover in focally damaged human ankle cartilage: evidence for a generalized response and active matrix remodeling across the entire joint surface

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12 December 2020

Characterization of metalloprotease cleavage products of human articular cartilage

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12 December 2020

Osteoarthritic change is delayed in a Ctsk-knockout mouse model of osteoarthritis

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12 December 2020

Selective enhancement of collagenase-mediated cleavage of resident type II collagen in cultured osteoarthritic cartilage and arrest with a synthetic inhibitor that spares collagenase 1 (matrix metalloproteinase 1)

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12 December 2020

The increased swelling and instantaneous deformation of osteoarthritic cartilage is highly correlated with collagen degradation

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12 December 2020

Collagen type II C-telopeptide fragments as an index of cartilage degradation

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12 December 2020

Sites of collagenase cleavage and denaturation of type II collagen in aging and osteoarthritic articular cartilage and their relationship to the distribution of matrix metalloproteinase 1 and matrix metalloproteinase 13

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12 December 2020

Cleavage site specificity of cathepsin K toward cartilage proteoglycans and protease complex formation

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12 December 2020

Identifiers

DOI

10.1186/AR3839

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Dimensions Publication ID

13 August 2017

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13 August 2017

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