Design and synthesis of potential mechanism-based inhibitors of the aminotransferase BioA involved in biotin biosynthesis. (Q36252957)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22724679%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

title

Design and synthesis of potential mechanism-based inhibitors of the aminotransferase BioA involved in biotin biosynthesis (English)

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1

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5 February 2020

author name string

Courtney C Aldrich

series ordinal

2

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5 February 2020

language of work or name

English

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publication date

3 July 2012

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22724679%20AND%20SRC:MED&resulttype=core&format=json

Journal of Organic Chemistry

5 February 2020

published in

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volume

77

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5 February 2020

issue

14

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5 February 2020

page(s)

6051-6058

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Mechanism-based Inactivation by Aromatization of the Transaminase BioA Involved in Biotin Biosynthesis in Mycobaterium tuberculosis

5 February 2020

cites work

1 reference

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Evaluating the sensitivity of Mycobacterium tuberculosis to biotin deprivation using regulated gene expression

30 September 2017

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A continuous fluorescence displacement assay for BioA: an enzyme involved in biotin biosynthesis.

30 September 2017

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Pyridoxal-5'-phosphate-dependent enzymes involved in biotin biosynthesis: structure, reaction mechanism and inhibition

30 September 2017

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Mechanism of Inactivation of Escherichia coli Aspartate Aminotransferase by ( S )-4-Amino-4,5-dihydro-2-furancarboxylic Acid,

30 September 2017

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Structural Characterization of the Mycobacterium tuberculosis Biotin Biosynthesis Enzymes 7,8-Diaminopelargonic Acid Synthase and Dethiobiotin Synthetase,

30 September 2017

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Chiral discrimination among aminotransferases: inactivation by 4-amino-4,5-dihydrothiophenecarboxylic acid

30 September 2017

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Inhibition of 7,8-diaminopelargonic acid aminotransferase from Mycobacterium tuberculosis by chiral and achiral anologs of its substrate: biological implications

30 September 2017

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30 September 2017

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Inactivation of Escherichia coli L-aspartate aminotransferase by (S)-4-amino-4,5-dihydro-2-thiophenecarboxylic acid reveals "a tale of two mechanisms"

30 September 2017

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(+/-)-(1S,2R,5S)-5-Amino-2-fluorocyclohex-3-enecarboxylic acid. A potent GABA aminotransferase inactivator that irreversibly inhibits via an elimination-aromatization pathway

30 September 2017

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7,8-Diaminoperlargonic acid aminotransferase from Mycobacterium tuberculosis, a potential therapeutic target. Characterization and inhibition studies

30 September 2017

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Genetic requirements for mycobacterial survival during infection

30 September 2017

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Catalytic Asymmetric Rearrangement of Allylic Trichloroacetimidates. A Practical Method for Preparing Allylic Amines and Congeners of High Enantiomeric Purity

30 September 2017

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Structural basis for the inhibition of the biosynthesis of biotin by the antibiotic amiclenomycin

30 September 2017

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Biosynthesis of biotin and lipoic acid

30 September 2017

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The biotin-dependent enzymes

30 September 2017

1 reference

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The mechanism of biotin-dependent enzymes

30 September 2017

1 reference

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Studies on a new amino acid antibiotic, amiclenomycin.

30 September 2017

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Metabolic products from microorganisms. 230. Amiclenomycin-peptides, new antimetabolites of biotin. Taxonomy, fermentation and biological properties.

29 June 2018

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29 June 2018

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Total synthesis of aigialomycin D using a Ramberg-Bäcklund/RCM strategy

29 June 2018

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Variable strategy toward carbasugars and relatives. 6. Diastereoselective synthesis of 2-deoxy-2-amino-5a-carba-beta-L-mannopyranuronic acid and 2-deoxy-2-amino-5a-carba-beta-L-mannopyranose

22 September 2018

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Design and synthesis of potent, orally active, inhibitors of carboxypeptidase U (TAFIa).

22 September 2018

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Inactivation of gamma-aminobutyric acid aminotransferase by (S)-4-amino-4,5-dihydro-2-furancarboxylic acid does not proceed by the expected aromatization mechanism

22 September 2018

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Design, synthesis, and biological activity of a difluoro-substituted, conformationally rigid vigabatrin analogue as a potent gamma-aminobutyric acid aminotransferase inhibitor

22 September 2018

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Intramolecular silicon-assisted cross-coupling reactions: general synthesis of medium-sized rings containing a 1,3-cis-cis diene unit

22 September 2018

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Total synthesis of amiclenomycin, an inhibitor of biotin biosynthesis

22 September 2018

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Isolation and characterization of the product of inactivation of gamma-aminobutyric acid aminotransferase by gabaculine

22 September 2018

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Determination of free biotin in plasma by liquid chromatography with fluorimetric detection

22 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22724679

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Facile synthesis of alpha-substituted acrylate esters

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22724679

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Studies of the mode of action of amiclenomycin

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22724679

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1021/JO3008435

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22724679%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

1 reference

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5 February 2020

PubMed publication ID

22724679

1 reference