The role of amino acids in extracellular loops of the human P2Y1 receptor in surface expression and activation processes. (Q36253724)

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8 December 2019

title

The role of amino acids in extracellular loops of the human P2Y1 receptor in surface expression and activation processes (English)

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8 December 2019

2

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8 December 2019

Kenneth A. Jacobson

5

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8 December 2019

author name string

C Hoffmann

1

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8 December 2019

R A Nicholas

3

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8 December 2019

T K Harden

4

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8 December 2019

language of work or name

English

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publication date

1 May 1999

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Journal of Biological Chemistry

8 December 2019

published in

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8 December 2019

volume

274

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8 December 2019

issue

21

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8 December 2019

page(s)

14639-14647

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Molecular Architecture of G Protein-Coupled Receptors.

8 December 2019

cites work

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Role of the extracellular loops of G protein-coupled receptors in ligand recognition: a molecular modeling study of the human P2Y1 receptor.

30 September 2017

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Coactivation of two different G protein-coupled receptors is essential for ADP-induced platelet aggregation

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Human P2Y1 receptor: molecular modeling and site-directed mutagenesis as tools to identify agonist and antagonist recognition sites.

30 September 2017

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A mutational analysis of residues essential for ligand recognition at the human P2Y1 receptor.

30 September 2017

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An examination of deoxyadenosine 5'(alpha-thio)triphosphate as a ligand to define P2Y receptors and its selectivity as a low potency partial agonist of the P2Y1 receptor

30 September 2017

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Role of the Cys90, Cys95 and Cys173 residues in the structure and function of the human platelet-activating factor receptor

30 September 2017

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Modelling the P2Y purinoceptor using rhodopsin as template

30 September 2017

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Identification of potent P2Y-purinoceptor agonists that are derivatives of adenosine 5'-monophosphate

30 September 2017

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A disulfide bonding interaction role for cysteines in the extracellular domain of the thyrotropin-releasing hormone receptor

30 September 2017

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Double tagging recombinant A1- and A2A-adenosine receptors with hexahistidine and the FLAG epitope. Development of an efficient generic protein purification procedure

30 September 2017

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Glutamate residues in the second extracellular loop of the human A2a adenosine receptor are required for ligand recognition

30 September 2017

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The peptide binding site of the substance P (NK-1) receptor localized by a photoreactive analogue of substance P: presence of a disulfide bond

30 September 2017

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Identification of a receptor/G-protein contact site critical for signaling specificity and G-protein activation

30 September 2017

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Identification of potent, selective P2Y-purinoceptor agonists: structure-activity relationships for 2-thioether derivatives of adenosine 5'-triphosphate

30 September 2017

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Mutation of aspartate residues in the third extracellular loop of the rat B2 bradykinin receptor decreases affinity for bradykinin

30 September 2017

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Nomenclature and classification of purinoceptors.

30 September 2017

1 reference

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Role of the second extracellular loop of adenosine receptors in agonist and antagonist binding. Analysis of chimeric A1/A3 adenosine receptors

30 September 2017

1 reference

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Purinoceptors: are there families of P2X and P2Y purinoceptors?

30 September 2017

1 reference

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Changes in the levels of inositol phosphates after agonist-dependent hydrolysis of membrane phosphoinositides

30 September 2017

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Use of eukaryotic expression technology in the functional analysis of cloned genes

30 September 2017

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DNA sequencing with chain-terminating inhibitors

30 September 2017

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Importance of extracellular domains for ligand binding in the thyrotropin-releasing hormone receptor

30 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3449168

Disulfide bridges in extracellular domains of angiotensin II receptor type IA.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3449168

Mutational analysis of the angiotensin II type 2 receptor: contribution of conserved extracellular amino acids.

30 September 2017

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Modes of peptide binding in G protein-coupled receptors

29 June 2018

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A review of mutagenesis studies of angiotensin II type 1 receptor, the three-dimensional receptor model in search of the agonist and antagonist binding site and the hypothesis of a receptor activation mechanism

29 June 2018

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Identification of four amino acids in the gastrin-releasing peptide receptor that are required for high affinity agonist binding

29 June 2018

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Thrombin receptor activating mutations. Alteration of an extracellular agonist recognition domain causes constitutive signaling

29 June 2018

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Phosphoinositide hydrolysis by guanosine 5'-[gamma-thio]triphosphate-activated phospholipase C of turkey erythrocyte membranes

29 June 2018

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Role of the extracellular domains of the cholecystokinin receptor in agonist binding.

29 June 2018

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Complete mutagenesis of the extracellular domain of interleukin-8 (IL-8) type A receptor identifies charged residues mediating IL-8 binding and signal transduction

22 September 2018

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Mechanisms of thrombin receptor agonist specificity. Chimeric receptors and complementary mutations identify an agonist recognition site

22 September 2018

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A disulfide bonding interaction role for cysteines in the extracellular domain of the thyrotropin-releasing hormone receptor

22 September 2018

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Crossref

https://api.crossref.org/works/10.1074%2FJBC.274.21.14639

Acidic residues in extracellular loops of the human Y1 neuropeptide Y receptor are essential for ligand binding

21 January 2018

1 reference

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Deoxyadenosine bisphosphate derivatives as potent antagonists at P2Y1 receptors

21 October 2018

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12 December 2020

Use of a sandwich enzyme-linked immunosorbent assay strategy to study mechanisms of G protein-coupled receptor assembly

1 reference

12 December 2020

Role of the extracellular loops of the thyrotropin-releasing hormone receptor: evidence for an initial interaction with thyrotropin-releasing hormone

1 reference

12 December 2020

Site-directed mutagenesis of P2U purinoceptors. Positively charged amino acids in transmembrane helices 6 and 7 affect agonist potency and specificity

1 reference

12 December 2020

Localization of the ligand binding site of the neurokinin-1 receptor: interpretation of chimeric mutations and single-residue substitutions

1 reference

12 December 2020

Identification of critical extracellular loop residues involved in alpha 1-adrenergic receptor subtype-selective antagonist binding

1 reference

12 December 2020

The docking of Arg2 of angiotensin II with Asp281 of AT1 receptor is essential for full agonism

1 reference

12 December 2020

Identification of peptide binding residues in the extracellular domains of the AT1 receptor

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.274.21.14639

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10329657%20AND%20SRC:MED&resulttype=core&format=json

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8 December 2019

Fatcat ID

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Fatcat

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24 November 2022

mapped directly with Wikidata item

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8 December 2019

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