Ruboxistaurin, a protein kinase C beta inhibitor, as an emerging treatment for diabetes microvascular complications (Q36256287)

13 August 2017

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title

Ruboxistaurin, a protein kinase C beta inhibitor, as an emerging treatment for diabetes microvascular complications (English)

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13 August 2017

Scott V Joy

1

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13 August 2017

Ann C Scates

2

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13 August 2017

Srilaxmi Bearelly

3

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13 August 2017

Moahad Dar

4

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13 August 2017

Christina A Taulien

5

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13 August 2017

Jason A Goebel

6

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13 August 2017

Michael J Cooney

7

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13 August 2017

language of work or name

English

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publication date

13 September 2005

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Annals of Pharmacotherapy

13 August 2017

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13 August 2017

39

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13 August 2017

10

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13 August 2017

1693-1699

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Global burden of diabetes, 1995-2025: prevalence, numerical estimates, and projections

13 August 2017

1 reference

Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group

21 January 2018

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The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. The Diabetes Control and Complications Trial Research Group

21 January 2018

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Protein kinase C and the development of diabetic vascular complications

21 January 2018

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Molecular understanding of hyperglycemia's adverse effects for diabetic complications

21 January 2018

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Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage

21 January 2018

1 reference

Hyperglycemia-induced mitochondrial superoxide overproduction activates the hexosamine pathway and induces plasminogen activator inhibitor-1 expression by increasing Sp1 glycosylation

21 January 2018

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Identification of PKC-isoform-specific biological actions using pharmacological approaches

21 January 2018

1 reference

Protein kinase C isotypes and their specific functions: prologue

21 January 2018

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Dual role of pseudosubstrate in the coordinated regulation of protein kinase C by phosphorylation and diacylglycerol

21 January 2018

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Protein kinase C activation: isozyme-specific effects on metabolism and cardiovascular complications in diabetes

21 January 2018

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Mitogen-activated protein kinases as glucose transducers for diabetic complications

21 January 2018

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Diacylglycerol accumulation and microvascular abnormalities induced by elevated glucose levels

21 January 2018

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How hyperglycemia promotes atherosclerosis: molecular mechanisms

21 January 2018

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The interactions of a selective protein kinase C beta inhibitor with the human cytochromes P450.

21 January 2018

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The prevalence of diabetic retinopathy among adults in the United States

21 January 2018

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Protein kinase C activation and its role in the development of vascular complications in diabetes mellitus

21 January 2018

1 reference

Protein kinase C activation and the development of diabetic complications

21 January 2018

1 reference

Potential new medical therapies for diabetic retinopathy: protein kinase C inhibitors

21 January 2018

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Vascular endothelial growth factors and angiogenesis in eye disease

21 January 2018

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Role of protein kinase C on the expression of platelet-derived growth factor and endothelin-1 in the retina of diabetic rats and cultured retinal capillary pericytes

21 January 2018

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Characterization of vascular endothelial growth factor's effect on the activation of protein kinase C, its isoforms, and endothelial cell growth

21 January 2018

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Characterization of protein kinase C beta isoform's action on retinoblastoma protein phosphorylation, vascular endothelial growth factor-induced endothelial cell proliferation, and retinal neovascularization

21 January 2018

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Protein kinase C inhibition and diabetic retinopathy: a shot in the dark at translational research

21 January 2018

1 reference

21 January 2018

Diabetic neuropathies

1 reference

Vascular factors and metabolic interactions in the pathogenesis of diabetic neuropathy.

21 January 2018

1 reference

The development and validation of a neuropathy- and foot ulcer-specific quality of life instrument.

21 January 2018

1 reference

Simple screening tests for peripheral neuropathy in the diabetes clinic.

21 January 2018

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International consensus and practical guidelines on the management and the prevention of the diabetic foot. International Working Group on the Diabetic Foot

21 January 2018

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A reassessment of vascular factors in relation to intravascular coagulation.

21 January 2018

1 reference

Protein kinase C changes in diabetes: is the concept relevant to neuropathy?

21 January 2018

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Microalbuminuria, blood pressure and diabetic renal disease: origin and development of ideas

21 January 2018

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Mesangial cell protein kinase C isozyme activation in the diabetic milieu

21 January 2018

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Pathogenesis, prevention, and treatment of diabetic nephropathy.

21 January 2018

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Vascular endothelial growth factor: a new player in the pathogenesis of renal fibrosis

21 January 2018

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Vascular endothelial growth factor mRNA expression in minimal change, membranous, and diabetic nephropathy demonstrated by non-isotopic in situ hybridisation

21 January 2018

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Prevention of diabetic nephropathy in rats by prostaglandin E receptor EP1-selective antagonist

21 January 2018

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A novel potential therapy for diabetic nephropathy and vascular complications: protein kinase C beta inhibition

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1345/APH.1E572

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13 August 2017

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