Structural basis for receptor subtype-specific regulation revealed by a chimeric beta 3/beta 2-adrenergic receptor. (Q36257343)

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30 October 2019

title

Structural basis for receptor subtype-specific regulation revealed by a chimeric beta 3/beta 2-adrenergic receptor (English)

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30 October 2019

3

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4

R J Lefkowitz

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30 October 2019

author name string

S B Liggett

series ordinal

1

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N J Freedman

series ordinal

2

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30 October 2019

language of work or name

English

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publication date

1 April 1993

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Proceedings of the National Academy of Sciences of the United States of America

30 October 2019

published in

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volume

90

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30 October 2019

page(s)

3665-3669

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30 October 2019

issue

8

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Generation of protein-reactive antibodies by short peptides is an event of high frequency: implications for the structural basis of immune recognition.

30 October 2019

cites work

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Use of eukaryotic expression technology in the functional analysis of cloned genes

30 September 2017

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cDNA for the human beta 2-adrenergic receptor: a protein with multiple membrane-spanning domains and encoded by a gene whose chromosomal location is shared with that of the receptor for platelet-derived growth factor

30 September 2017

1 reference

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Structural basis of beta-adrenergic receptor subtype specificity studied with chimeric beta 1/beta 2-adrenergic receptors

30 September 2017

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Chimeric alpha 2-,beta 2-adrenergic receptors: delineation of domains involved in effector coupling and ligand binding specificity

30 September 2017

1 reference

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Cloning of the cDNA for the human beta 1-adrenergic receptor

30 September 2017

1 reference

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Molecular characterization of the human beta 3-adrenergic receptor

30 September 2017

1 reference

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Beta-adrenergic receptor kinase: primary structure delineates a multigene family

30 September 2017

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Phosphorylation sites on two domains of the beta 2-adrenergic receptor are involved in distinct pathways of receptor desensitization.

30 September 2017

1 reference

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Involvement of tyrosine residues located in the carboxyl tail of the human beta 2-adrenergic receptor in agonist-induced down-regulation of the receptor

30 September 2017

1 reference

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A small region of the beta-adrenergic receptor is selectively involved in its rapid regulation

30 September 2017

1 reference

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Long-term agonist exposure induces upregulation of beta 3-adrenergic receptor expression via multiple cAMP response elements

30 September 2017

1 reference

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Two distinct pathways for cAMP-mediated down-regulation of the beta 2-adrenergic receptor. Phosphorylation of the receptor and regulation of its mRNA level

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=46362

Multiple pathways of rapid beta 2-adrenergic receptor desensitization. Delineation with specific inhibitors

29 June 2018

1 reference

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Mutations of the human beta 2-adrenergic receptor that impair coupling to Gs interfere with receptor down-regulation but not sequestration

29 June 2018

1 reference

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Role of acidic amino acids in peptide substrates of the .beta.-adrenergic receptor kinase and rhodopsin kinase

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=46362

Sites in the third intracellular loop of the alpha 2A-adrenergic receptor confer short term agonist-promoted desensitization. Evidence for a receptor kinase-mediated mechanism

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=46362

Differential adrenergic regulation of beta 1- and beta 3-adrenoreceptor messenger ribonucleic acids in adipose tissues

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=46362

Altered patterns of agonist-stimulated cAMP accumulation in cells expressing mutant beta 2-adrenergic receptors lacking phosphorylation sites

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=46362

Removal of phosphorylation sites from the β2-adrenergic receptor delays onset of agonist-promoted desensitization

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=46362

Effects of agonist exposure on the coupling of beta 1 and beta 3 adrenergic receptors to adenylyl cyclase in isolated adipocytes

5 December 2018

1 reference

12 December 2020

Functional properties of the rat and human beta 3-adrenergic receptors: differential agonist activation of recombinant receptors in Chinese hamster ovary cells

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12 December 2020

Beta-adrenergic receptor sequestration. A potential mechanism of receptor resensitization

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12 December 2020

Identification of a specific site required for rapid heterologous desensitization of the beta-adrenergic receptor by cAMP-dependent protein kinase

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12 December 2020

Identifiers

DOI

10.1073/PNAS.90.8.3665

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8386380%20AND%20SRC:MED&resulttype=core&format=json

30 October 2019

0 references

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30 October 2019

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