Metformin inhibits hepatocellular glucose, lipid and cholesterol biosynthetic pathways by transcriptionally suppressing steroid receptor coactivator 2 (SRC-2). (Q36262595)

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English	Metformin inhibits hepatocellular glucose, lipid and cholesterol biosynthetic pathways by transcriptionally suppressing steroid receptor coactivator 2 (SRC-2).	scientific article

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29 February 2020

Metformin inhibits hepatocellular glucose, lipid and cholesterol biosynthetic pathways by transcriptionally suppressing steroid receptor coactivator 2 (SRC-2) (English)

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29 February 2020

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29 February 2020

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29 February 2020

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29 February 2020

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Olivera Bozickovic

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29 February 2020

Jan-Inge Bjune

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29 February 2020

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9 November 2015

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29 February 2020

Scientific Reports

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29 February 2020

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29 February 2020

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29 February 2020

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9 November 2015

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0 references

Metformin and salicylate synergistically activate liver AMPK, inhibit lipogenesis and improve insulin sensitivity

1 reference

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30 September 2017

Pharmacologic treatment of type 2 diabetes: oral medications

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30 September 2017

Coactivator SRC-2-dependent metabolic reprogramming mediates prostate cancer survival and metastasis

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30 September 2017

Androgen deprivation therapy induces androgen receptor-dependent upregulation of Egr1 in prostate cancers

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30 September 2017

Steroid receptor coactivators: servants and masters for control of systems metabolism

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4637908

30 September 2017

Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4637908

30 September 2017

SRC-2 is an essential coactivator for orchestrating metabolism and circadian rhythm

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4637908

30 September 2017

Downregulation of steroid receptor coactivator-2 modulates estrogen-responsive genes and stimulates proliferation of mcf-7 breast cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4637908

30 September 2017

Large-scale gene function analysis with the PANTHER classification system

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30 September 2017

Dietary obesity-induced Egr-1 in adipocytes facilitates energy storage via suppression of FOXC2.

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30 September 2017

Distinct perturbation of the translatome by the antidiabetic drug metformin

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30 September 2017

Cellular and molecular mechanisms of metformin: an overview

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30 September 2017

Early growth response 1 (Egr1) regulates cholesterol biosynthetic gene expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4637908

30 September 2017

Steroid receptor coactivators 1, 2, and 3: critical regulators of nuclear receptor activity and steroid receptor modulator (SRM)-based cancer therapy

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30 September 2017

Control of nuclear receptor activities in metabolism by post-translational modifications

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30 September 2017

CREB and the CRTC co-activators: sensors for hormonal and metabolic signals

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4637908

30 September 2017

Steroid Receptor Coactivator (SRC) Family: Masters of Systems Biology

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4637908

30 September 2017

Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state

1 reference

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30 September 2017

Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4637908

30 September 2017

Absence of the SRC-2 coactivator results in a glycogenopathy resembling Von Gierke's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4637908

30 September 2017

Recruitment of coactivator glucocorticoid receptor interacting protein 1 to an estrogen receptor transcription complex is regulated by the 3',5'-cyclic adenosine 5'-monophosphate-dependent protein kinase

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4637908

30 September 2017

Genome-wide analysis of estrogen receptor binding sites

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30 September 2017

The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin

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30 September 2017

The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism

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30 September 2017

Initiating oral glucose-lowering therapy with metformin in type 2 diabetic patients: an evidence-based strategy to reduce the burden of late-developing diabetes complications

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30 September 2017

SREBPs: transcriptional mediators of lipid homeostasis

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4637908

30 September 2017

The antidiabetic drug metformin activates the AMP-activated protein kinase cascade via an adenine nucleotide-independent mechanism

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30 September 2017

SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver

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30 September 2017

Role of AMP-activated protein kinase in mechanism of metformin action

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30 September 2017

Metformin reverses fatty liver disease in obese, leptin-deficient mice

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30 September 2017

Cellular energy depletion resets whole-body energy by promoting coactivator-mediated dietary fuel absorption.

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Metformin use and all-cause and prostate cancer-specific mortality among men with diabetes

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Metformin and atorvastatin combination further protect the liver in type 2 diabetes with hyperlipidaemia.

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The effect of metformin on leptin in obese patients with type 2 diabetes mellitus and nonalcoholic fatty liver disease

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22 September 2018

The genomic analysis of the impact of steroid receptor coactivators ablation on hepatic metabolism.

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22 September 2018

Metformin therapy increases insulin-like growth factor binding protein-1 in hyperinsulinemic women with polycystic ovary syndrome.

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Effect of metformin on insulin-like growth factor (IGF) I and IGF-binding protein I in polycystic ovary syndrome.

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SRC-1 and TIF2 control energy balance between white and brown adipose tissues

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12 December 2020

based on heuristic

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The antidiabetic drug metformin decreases cholesterol metabolism in cultured human fibroblasts

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https://pubmed.ncbi.nlm.nih.gov/26548416

12 December 2020

based on heuristic

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The blooming of the French lilac

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12 April 2024

https://opencitations.net/index/api/v1/citations/10.1172/JCI14178

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10.1038/SREP16430

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29 February 2020

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29 February 2020

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