The combination of colistin and doripenem is synergistic against Klebsiella pneumoniae at multiple inocula and suppresses colistin resistance in an in vitro pharmacokinetic/pharmacodynamic model (Q36276852)

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English	The combination of colistin and doripenem is synergistic against Klebsiella pneumoniae at multiple inocula and suppresses colistin resistance in an in vitro pharmacokinetic/pharmacodynamic model	scientific article

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8 February 2020

The combination of colistin and doripenem is synergistic against Klebsiella pneumoniae at multiple inocula and suppresses colistin resistance in an in vitro pharmacokinetic/pharmacodynamic model (English)

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8 February 2020

Klebsiella pneumoniae

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pharmacodynamics

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based on heuristic

inferred from title

pharmacokinetics

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based on heuristic

inferred from title

Juergen Bulitta

10

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8 February 2020

David L Paterson

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8 February 2020

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8 February 2020

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8 February 2020

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Roger L Nation

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8 February 2020

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Rachel L Soon

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8 February 2020

Zakuan Zainy Deris

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Zakuan Z Deris

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8 February 2020

Phillip J Bergen

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Phillip J Bergen

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8 February 2020

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Brian T Tsuji

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8 February 2020

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Anima Poudyal

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8 February 2020

author name string

Heidi H Yu

2

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8 February 2020

Kathryn Davis

3

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8 February 2020

Jovan Jacob

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8 February 2020

Caron K Ku

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8 February 2020

Alan Forrest

11

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8 February 2020

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publication date

16 July 2012

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8 February 2020

Antimicrobial Agents and Chemotherapy

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8 February 2020

56

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8 February 2020

10

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8 February 2020

5103-5112

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8 February 2020

The combination of doripenem and colistin is bactericidal and synergistic against colistin-resistant, carbapenemase-producing Klebsiella pneumoniae

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3457376

30 September 2017

Synergistic killing of multidrug-resistant Pseudomonas aeruginosa at multiple inocula by colistin combined with doripenem in an in vitro pharmacokinetic/pharmacodynamic model

1 reference

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30 September 2017

Clinically relevant plasma concentrations of colistin in combination with imipenem enhance pharmacodynamic activity against multidrug-resistant Pseudomonas aeruginosa at multiple inocula

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3457376

30 September 2017

Colistin-resistant, Klebsiella pneumoniae carbapenemase (KPC)-producing Klebsiella pneumoniae belonging to the international epidemic clone ST258.

1 reference

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30 September 2017

Population pharmacokinetics of colistin methanesulfonate and formed colistin in critically ill patients from a multicenter study provide dosing suggestions for various categories of patients

1 reference

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30 September 2017

Combating antimicrobial resistance: policy recommendations to save lives

1 reference

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30 September 2017

NDM-1--a cause for worldwide concern.

1 reference

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30 September 2017

Outbreak of colistin-resistant, carbapenem-resistant Klebsiella pneumoniae in metropolitan Detroit, Michigan

1 reference

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30 September 2017

Resurgence of colistin: a review of resistance, toxicity, pharmacodynamics, and dosing

1 reference

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30 September 2017

Multiresistant Gram-negative infections: a global perspective

1 reference

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30 September 2017

Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study

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30 September 2017

Colistin dosing and nephrotoxicity in a large community teaching hospital

1 reference

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30 September 2017

Pharmacokinetic/pharmacodynamic investigation of colistin against Pseudomonas aeruginosa using an in vitro model

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30 September 2017

fAUC/MIC is the most predictive pharmacokinetic/pharmacodynamic index of colistin against Acinetobacter baumannii in murine thigh and lung infection models.

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30 September 2017

Population pharmacokinetics of doripenem based on data from phase 1 studies with healthy volunteers and phase 2 and 3 studies with critically ill patients

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30 September 2017

In vitro double and triple bactericidal activities of doripenem, polymyxin B, and rifampin against multidrug-resistant Acinetobacter baumannii, Pseudomonas aeruginosa, Klebsiella pneumoniae, and Escherichia coli

1 reference

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30 September 2017

Attenuation of colistin bactericidal activity by high inoculum of Pseudomonas aeruginosa characterized by a new mechanism-based population pharmacodynamic model

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30 September 2017

Elucidation of the pharmacokinetic/pharmacodynamic determinant of colistin activity against Pseudomonas aeruginosa in murine thigh and lung infection models

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30 September 2017

Colistin in the 21st century

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30 September 2017

Nephrotoxicity associated with intravenous colistin (colistimethate sodium) treatment at a tertiary care medical center

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30 September 2017

Population pharmacokinetic analysis of colistin methanesulfonate and colistin after intravenous administration in critically ill patients with infections caused by gram-negative bacteria.

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30 September 2017

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30 September 2017

Bad bugs, no drugs: no ESKAPE! An update from the Infectious Diseases Society of America

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30 September 2017

Management of multidrug-resistant organisms in health care settings, 2006.

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30 September 2017

Heteroresistance to colistin in multidrug-resistant Acinetobacter baumannii

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30 September 2017

Colistin: the re-emerging antibiotic for multidrug-resistant Gram-negative bacterial infections

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30 September 2017

Colistin methanesulfonate is an inactive prodrug of colistin against Pseudomonas aeruginosa.

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30 September 2017

The forgotten Gram-negative bacilli: what genetic determinants are telling us about the spread of antibiotic resistance

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30 September 2017

Use of high-performance liquid chromatography to study the pharmacokinetics of colistin sulfate in rats following intravenous administration

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30 September 2017

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30 September 2017

Does the activity of the combination of imipenem and colistin in vitro exceed the problem of resistance in metallo-beta-lactamase-producing Klebsiella pneumoniae isolates?

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29 June 2018

Colistin heteroresistance in acinetobacter and its association with previous colistin therapy

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29 June 2018

Does bacterial density in cystic fibrosis sputum increase prior to pulmonary exacerbation?

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22 September 2018

Hospital outbreak caused by Klebsiella pneumoniae producing KPC-2 beta-lactamase resistant to colistin

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22 September 2018

Emergence of a colistin-resistant KPC-2-producing Klebsiella pneumoniae ST258 clone in Hungary.

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22 September 2018

Predictors of acute kidney injury associated with intravenous colistin treatment

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22 September 2018

Pharmacokinetic-pharmacodynamic modeling to support doripenem dose regimen optimization for critically ill patients.

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22 September 2018

In vitro pharmacodynamics of colistin against multidrug-resistant Klebsiella pneumoniae

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22 September 2018

Colistin-resistant isolates of Klebsiella pneumoniae emerging in intensive care unit patients: first report of a multiclonal cluster

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22 September 2018

Carbapenemase-producing Klebsiella pneumoniae in Brooklyn, NY: molecular epidemiology and in vitro activity of polymyxin B and other agents

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Colistin for Klebsiella pneumoniae-associated sepsis

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22 September 2018

Colistin hetero-resistance in multidrug-resistant Acinetobacter baumannii clinical isolates from the Western Pacific region in the SENTRY antimicrobial surveillance programme

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12 December 2020

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Detection of synergy using the combination of polymyxin B with either meropenem or rifampin against carbapenemase-producing Klebsiella pneumoniae

1 reference

https://pubmed.ncbi.nlm.nih.gov/22802247

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Old polymyxins are back: is resistance close?

1 reference

https://pubmed.ncbi.nlm.nih.gov/22802247

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Colistin heteroresistance in carbapenemase-producing Klebsiella pneumoniae

1 reference

https://pubmed.ncbi.nlm.nih.gov/22802247

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

EUCAST Definitive Document E.DEF 3.1, June 2000: Determination of minimum inhibitory concentrations (MICs) of antibacterial agents by agar dilution

1 reference

https://pubmed.ncbi.nlm.nih.gov/22802247

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1128/AAC.01064-12

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8 February 2020

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8 February 2020

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Europe PubMed Central

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8 February 2020

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