Systems toxicology: applications of toxicogenomics, transcriptomics, proteomics and metabolomics in toxicology (Q36279080)

13 August 2017

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title

Systems toxicology: applications of toxicogenomics, transcriptomics, proteomics and metabolomics in toxicology (English)

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13 August 2017

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Ben van Ommen

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author name string

Wilbert H M Heijne

1

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13 August 2017

Anne S Kienhuis

2

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13 August 2017

Ben van Ommen

3

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13 August 2017

Rob H Stierum

4

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13 August 2017

John P Groten

5

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13 August 2017

language of work or name

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1 October 2005

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Expert Review of Proteomics

13 August 2017

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13 August 2017

2

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13 August 2017

5

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13 August 2017

767-780

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Toxicology and genetic toxicology in the new era of "toxicogenomics": impact of "-omics" technologies

13 August 2017

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https://api.crossref.org/works/10.1586%2F14789450.2.5.767

Toxicogenomics and systems toxicology: aims and prospects

21 January 2018

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https://api.crossref.org/works/10.1586%2F14789450.2.5.767

Toxicogenetics: applications and opportunities

21 January 2018

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https://api.crossref.org/works/10.1586%2F14789450.2.5.767

Quantitative monitoring of gene expression patterns with a complementary DNA microarray

21 January 2018

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https://api.crossref.org/works/10.1586%2F14789450.2.5.767

Expression monitoring by hybridization to high-density oligonucleotide arrays

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2.5.767

Comprehensive identification of cell cycle-regulated genes of the yeast Saccharomyces cerevisiae by microarray hybridization

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2.5.767

Use of a cDNA microarray to analyse gene expression patterns in human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2.5.767

Exploring the metabolic and genetic control of gene expression on a genomic scale

21 January 2018

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https://api.crossref.org/works/10.1586%2F14789450.2.5.767

Cluster analysis and display of genome-wide expression patterns

21 January 2018

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https://api.crossref.org/works/10.1586%2F14789450.2.5.767

Genomics, gene expression and DNA arrays

21 January 2018

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https://api.crossref.org/works/10.1586%2F14789450.2.5.767

Toxicogenomics of bromobenzene hepatotoxicity: a combined transcriptomics and proteomics approach

21 January 2018

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https://api.crossref.org/works/10.1586%2F14789450.2.5.767

Bromobenzene-induced hepatotoxicity at the transcriptome level

21 January 2018

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https://api.crossref.org/works/10.1586%2F14789450.2.5.767

Gene expression profiling of rat livers reveals indicators of potential adverse effects.

21 January 2018

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https://api.crossref.org/works/10.1586%2F14789450.2.5.767

Identification of transformation sensitive proteins recorded in human two-dimensional gel protein databases by mass spectrometric peptide mapping alone and in combination with microsequencing.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2.5.767

Linking genome and proteome by mass spectrometry: large-scale identification of yeast proteins from two dimensional gels

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2.5.767

Two-dimensional database of mouse liver proteins: changes in hepatic protein levels following treatment with acetaminophen or its nontoxic regioisomer 3-acetamidophenol

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2.5.767

Matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS).

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2.5.767

Characterization of SDS--PAGE-separated proteins by matrix-assisted laser desorption/ionization mass spectrometry

21 January 2018

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https://api.crossref.org/works/10.1586%2F14789450.2.5.767

Quantitative profiling of differentiation-induced microsomal proteins using isotope-coded affinity tags and mass spectrometry

21 January 2018

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https://api.crossref.org/works/10.1586%2F14789450.2.5.767

Quantitative analysis of complex protein mixtures using isotope-coded affinity tags

21 January 2018

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https://api.crossref.org/works/10.1586%2F14789450.2.5.767

A combination of proteomics, principal component analysis and transcriptomics is a powerful tool for the identification of biomarkers for macrophage maturation in the U937 cell line.

21 January 2018

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https://api.crossref.org/works/10.1586%2F14789450.2.5.767

Toxicoproteomics: proteomics applied to toxicology and pathology

21 January 2018

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https://api.crossref.org/works/10.1586%2F14789450.2.5.767

'Metabonomics': understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2.5.767

Metabonomic characterization of genetic variations in toxicological and metabolic responses using probabilistic neural networks

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2.5.767

Molecular mechanisms of apoptosis induced by cytotoxic chemicals

21 January 2018

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https://api.crossref.org/works/10.1586%2F14789450.2.5.767

In silico approaches to mechanistic and predictive toxicology: an introduction to bioinformatics for toxicologists

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2.5.767

Gene expression data analysis

21 January 2018

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https://api.crossref.org/works/10.1586%2F14789450.2.5.767

Microarrays and toxicology: the advent of toxicogenomics

21 January 2018

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https://api.crossref.org/works/10.1586%2F14789450.2.5.767

Application of DNA arrays to toxicology

21 January 2018

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https://api.crossref.org/works/10.1586%2F14789450.2.5.767

DNA arrays: technology, options and toxicological applications

21 January 2018

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https://api.crossref.org/works/10.1586%2F14789450.2.5.767

The principles and practice of toxigenomics: applications and opportunities

21 January 2018

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https://api.crossref.org/works/10.1586%2F14789450.2.5.767

Challenges and limitations of gene expression profiling in mechanistic and predictive toxicology

21 January 2018

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https://api.crossref.org/works/10.1586%2F14789450.2.5.767

RNA expression in the early characterization of hepatotoxicants in Wistar rats by high-density DNA microarrays

21 January 2018

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https://api.crossref.org/works/10.1586%2F14789450.2.5.767

Clustering of hepatotoxins based on mechanism of toxicity using gene expression profiles

21 January 2018

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https://api.crossref.org/works/10.1586%2F14789450.2.5.767

Assessment of cisplatin-induced nephrotoxicity by microarray technology

21 January 2018

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https://api.crossref.org/works/10.1586%2F14789450.2.5.767

Expression profiling of acetaminophen liver toxicity in mice using microarray technology

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2.5.767

Use of cDNA microarrays to analyze dioxin-induced changes in human liver gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2.5.767

Toxicogenomics of resveratrol in rat liver.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2.5.767

NMR and pattern recognition studies on liver extracts and intact livers from rats treated with alpha-naphthylisothiocyanate

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2.5.767

Profiles of metabolites and gene expression in rats with chemically induced hepatic necrosis

21 January 2018

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https://api.crossref.org/works/10.1586%2F14789450.2.5.767

Toxicogenomic analysis of gene expression changes in rat liver after a 28-day oral benzene exposure

21 January 2018

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https://api.crossref.org/works/10.1586%2F14789450.2.5.767

Toxicogenomics-based discrimination of toxic mechanism in HepG2 human hepatoma cells

21 January 2018

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https://api.crossref.org/works/10.1586%2F14789450.2.5.767

Prediction of compound signature using high density gene expression profiling

21 January 2018

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https://api.crossref.org/works/10.1586%2F14789450.2.5.767

Proteomic analysis of plasma proteins of workers exposed to benzene

21 January 2018

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https://api.crossref.org/works/10.1586%2F14789450.2.5.767

Combination of 'omics' data to investigate the mechanism(s) of hydrazine-induced hepatotoxicity in rats and to identify potential biomarkers

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2.5.767

Surrogate tissue analysis: monitoring toxicant exposure and health status of inaccessible tissues through the analysis of accessible tissues and cells

21 January 2018

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https://api.crossref.org/works/10.1586%2F14789450.2.5.767

Toxicogenomics concepts and applications to study hepatic effects of food additives and chemicals

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2.5.767

Toxicogenomics in risk assessment: an overview of an HESI collaborative research program

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2.5.767

Influence of isolation procedure, extracellular matrix and dexamethasone on the regulation of membrane transporters gene expression in rat hepatocytes

21 January 2018

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https://api.crossref.org/works/10.1586%2F14789450.2.5.767

Assessment of hepatocytes and liver slices as in vitro test systems to predict in vivo gene expression

21 January 2018

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https://api.crossref.org/works/10.1586%2F14789450.2.5.767

Temporal gene expression analysis of monolayer cultured rat hepatocytes

21 January 2018

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https://api.crossref.org/works/10.1586%2F14789450.2.5.767

Gene expression in two hepatic cell lines, cultured primary hepatocytes, and liver slices compared to the in vivo liver gene expression in rats: possible implications for toxicogenomics use of in vitro systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2.5.767

Comparison of basal gene expression profiles and effects of hepatocarcinogens on gene expression in cultured primary human hepatocytes and HepG2 cells

21 January 2018

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https://api.crossref.org/works/10.1586%2F14789450.2.5.767

Human and animal hepatocytes in vitro with extrapolation in vivo

21 January 2018

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https://api.crossref.org/works/10.1586%2F14789450.2.5.767

Development of a toxicological gene array and quantitative assessment of this technology

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2.5.767

Microarray analysis of hepatotoxins in vitro reveals a correlation between gene expression profiles and mechanisms of toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2.5.767

Use of a low-density microarray for studying gene expression patterns induced by hepatotoxicants on primary cultures of rat hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2.5.767

Genomics and proteomics analysis of acetaminophen toxicity in mouse liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2.5.767

Transcriptomic and proteomic responses of human renal HEK293 cells to uranium toxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2.5.767

Workshop overview: use of genomic data in risk assessment.

21 January 2018

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https://api.crossref.org/works/10.1586%2F14789450.2.5.767

Proton NMR spectroscopy of bile for monitoring the excretion of endogenous and xenobiotic metabolites: Application to para-aminophenol

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2.5.767

Nuclear Magnetic Resonance Spectroscopic and Principal Components Analysis Investigations into Biochemical Effects of Three Model Hepatotoxins

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2.5.767

21 January 2018

Identifiers

DOI

10.1586/14789450.2.5.767

1 reference

13 August 2017

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