Using microarray gene signatures to elucidate mechanisms of antibiotic action and resistance (Q36280830)

13 August 2017

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title

Using microarray gene signatures to elucidate mechanisms of antibiotic action and resistance (English)

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13 August 2017

2

Robert E W Hancock

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13 August 2017

Michelle D Brazas

1

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13 August 2017

1 September 2005

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13 August 2017

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13 August 2017

10

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13 August 2017

18

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13 August 2017

1245-1252

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Antibiotics: where did we go wrong?

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Whole-genome random sequencing and assembly of Haemophilus influenzae Rd

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Computing prokaryotic gene ubiquity: rescuing the core from extinction

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Determination of the core of a minimal bacterial gene set

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Comprehensive transposon mutant library of Pseudomonas aeruginosa

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Harnessing the power of the genome in the search for new antibiotics

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Peptide deformylase as an antibacterial drug target: target validation and resistance development

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Bacterial fatty-acid biosynthesis: a genomics-driven target for antibacterial drug discovery

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Taking inventory: antibacterial agents currently at or beyond phase 1.

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Comparison of cefepime, cefpirome, and cefaclidine binding affinities for penicillin-binding proteins in Escherichia coli K-12 and Pseudomonas aeruginosa SC8329

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Approaching the physiological functions of penicillin-binding proteins in Escherichia coli.

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Target for bacteriostatic and bactericidal activities of beta-lactam antibiotics against Escherichia coli resides in different penicillin-binding proteins

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7 January 2021

Aminoglycoside uptake and mode of action-with special reference to streptomycin and gentamicin. II. Effects of aminoglycosides on cells

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Aminoglycoside uptake and mode of action--with special reference to streptomycin and gentamicin. I. Antagonists and mutants

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Structure and mechanism of action of an indolicidin peptide derivative with improved activity against gram-positive bacteria

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Sublethal concentrations of pleurocidin-derived antimicrobial peptides inhibit macromolecular synthesis in Escherichia coli

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Alterations in outer membrane permeability

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Drug target validation and identification of secondary drug target effects using DNA microarrays

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The impact of transcriptome and proteome analyses on antibiotic drug discovery

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Transcriptional profiling and drug discovery.

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Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors

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Expression monitoring by hybridization to high-density oligonucleotide arrays

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Quantitative monitoring of gene expression patterns with a complementary DNA microarray

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Prediction of mechanisms of action of antibacterial compounds by gene expression profiling.

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Gene expression changes triggered by exposure of Haemophilus influenzae to novobiocin or ciprofloxacin: combined transcription and translation analysis

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Comparison of the changes in global gene expression of Escherichia coli induced by four bactericidal agents.

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Transcriptional regulation and signature patterns revealed by microarray analyses of Streptococcus pneumoniae R6 challenged with sublethal concentrations of translation inhibitors

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Interfering with Different Steps of Protein SynthesisExplored by Transcriptional Profiling of Escherichia coli K-12

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Exploring drug-induced alterations in gene expression in Mycobacterium tuberculosis by microarray hybridization

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Signature gene expression profiles discriminate between isoniazid-, thiolactomycin-, and triclosan-treated Mycobacterium tuberculosis

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Acetic acid induces expression of the Staphylococcus aureus cidABC and lrgAB murein hydrolase regulator operons

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Combined, functional genomic-biochemical approach to intermediary metabolism: interaction of acivicin, a glutamine amidotransferase inhibitor, with Escherichia coli K-12

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DNA microarray analysis of the expression profile of Escherichia coli in response to treatment with 4,5-dihydroxy-2-cyclopenten-1-one

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7 January 2021

Killing by ampicillin and ofloxacin induces overlapping changes in Escherichia coli transcription profile.

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Functional discovery via a compendium of expression profiles

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Discovering the mechanism of action of novel antibacterial agents through transcriptional profiling of conditional mutants

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Proteomic approach to understanding antibiotic action

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Genome-wide transcriptional profiling of the response of Staphylococcus aureus to cell-wall-active antibiotics reveals a cell-wall-stress stimulon

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Minimum information about a microarray experiment (MIAME)-toward standards for microarray data

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ArrayExpress--a public repository for microarray gene expression data at the EBI

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Gene Expression Omnibus: NCBI gene expression and hybridization array data repository

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Identification of antimicrobial targets using a comprehensive genomic approach

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Validation of antibacterial mechanism of action using regulated antisense RNA expression in Staphylococcus aureus.

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7 January 2021

Transcriptional modulation of bacterial gene expression by subinhibitory concentrations of antibiotics

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Panel of Bacillus subtilis reporter strains indicative of various modes of action

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Identifiers

DOI

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13 August 2017

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PubMed ID

16213417