Induction of novel agonist selectivity for the ADP-activated P2Y1 receptor versus the ADP-activated P2Y12 and P2Y13 receptors by conformational constraint of an ADP analog. (Q36282943)

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English	Induction of novel agonist selectivity for the ADP-activated P2Y1 receptor versus the ADP-activated P2Y12 and P2Y13 receptors by conformational constraint of an ADP analog.	scientific article

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1 January 2020

Induction of novel agonist selectivity for the ADP-activated P2Y1 receptor versus the ADP-activated P2Y12 and P2Y13 receptors by conformational constraint of an ADP analog (English)

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1 January 2020

Kenneth A. Jacobson

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1 January 2020

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Mariya Chhatriwala

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1 January 2020

R Gnana Ravi

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1 January 2020

Roshni I Patel

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1 January 2020

Jose L Boyer

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1 January 2020

T Kendall Harden

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1 January 2020

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2 September 2004

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1 January 2020

Journal of Pharmacology and Experimental Therapeutics

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1 January 2020

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1 January 2020

3

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1 January 2020

1038-1043

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1 January 2020

Quantitation of the P2Y(1) receptor with a high affinity radiolabeled antagonist

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30 September 2017

Adenine nucleotide analogues locked in a Northern methanocarba conformation: enhanced stability and potency as P2Y(1) receptor agonists

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459333

30 September 2017

2-Chloro N(6)-methyl-(N)-methanocarba-2'-deoxyadenosine-3',5'-bisphosphate is a selective high affinity P2Y(1) receptor antagonist

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459333

30 September 2017

Methanocarba modification of uracil and adenine nucleotides: high potency of Northern ring conformation at P2Y1, P2Y2, P2Y4, and P2Y11 but not P2Y6 receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459333

30 September 2017

Identification of a novel human ADP receptor coupled to G(i)

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30 September 2017

Platelet activation by ADP: the role of ADP antagonists

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459333

30 September 2017

Identification of the platelet ADP receptor targeted by antithrombotic drugs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459333

30 September 2017

Extracellular metabolism of ATP and other nucleotides

1 reference

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30 September 2017

Molecular biology of P2Y receptors expressed in the nervous system.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459333

30 September 2017

ADP receptors and clinical bleeding disorders

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459333

30 September 2017

Receptors for purines and pyrimidines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459333

30 September 2017

Coactivation of two different G protein-coupled receptors is essential for ADP-induced platelet aggregation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459333

30 September 2017

P2Y1-receptors in human platelets which are pharmacologically distinct from P2Y(ADP)-receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459333

30 September 2017

Molecular basis for ADP-induced platelet activation. II. The P2Y1 receptor mediates ADP-induced intracellular calcium mobilization and shape change in platelets

1 reference

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30 September 2017

Fidelity in functional coupling of the rat P2Y1 receptor to phospholipase C.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459333

30 September 2017

Second messenger cascade specificity and pharmacological selectivity of the human P2Y1-purinoceptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459333

30 September 2017

Signal transduction via P2-purinergic receptors for extracellular ATP and other nucleotides

1 reference

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30 September 2017

Differential effects of P2-purinoceptor antagonists on phospholipase C- and adenylyl cyclase-coupled P2Y-purinoceptors

1 reference

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30 September 2017

Release, metabolism and interconversion of adenine and uridine nucleotides: implications for G protein-coupled P2 receptor agonist selectivity

1 reference

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30 September 2017

Competitive and selective antagonism of P2Y1 receptors by N6-methyl 2'-deoxyadenosine 3',5'-bisphosphate

1 reference

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29 June 2018

Identification of competitive antagonists of the P2Y1 receptor.

1 reference

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29 June 2018

Recombinant Gq alpha. Mutational activation and coupling to receptors and phospholipase C

1 reference

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29 June 2018

Agonist binding and Gq-stimulating activities of the purified human P2Y1 receptor

1 reference

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22 September 2018

Acyclic and cyclopropyl analogues of adenosine bisphosphate antagonists of the P2Y1 receptor: structure-activity relationships and receptor docking

1 reference

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22 September 2018

The P2Y1 receptor, necessary but not sufficient to support full ADP-induced platelet aggregation, is not the target of the drug clopidogrel

1 reference

https://pubmed.ncbi.nlm.nih.gov/15345752

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acyclic analogues of deoxyadenosine 3',5'-bisphosphates as P2Y(1) receptor antagonists

1 reference

https://pubmed.ncbi.nlm.nih.gov/15345752

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthesis, Biological Activity, and Molecular Modeling of Ribose-Modified Deoxyadenosine Bisphosphate Analogues as P2Y1Receptor Ligands

1 reference

https://pubmed.ncbi.nlm.nih.gov/15345752

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ADP receptors of platelets and their inhibition

1 reference

https://pubmed.ncbi.nlm.nih.gov/15345752

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence that UTP and ATP regulate phospholipase C through a common extracellular 5'-nucleotide receptor in human airway epithelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/15345752

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ADP induced blood platelet activation: a review

1 reference

https://pubmed.ncbi.nlm.nih.gov/15345752

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of a P2Y-purinergic receptor that inhibits adenylyl cyclase

1 reference

https://pubmed.ncbi.nlm.nih.gov/15345752

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multiple P2 receptor subtypes on platelets: a new interpretation of their function

1 reference

https://pubmed.ncbi.nlm.nih.gov/15345752

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1124/JPET.104.068650

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1 January 2020

1 reference

Europe PubMed Central

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1 January 2020

1 reference

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1 January 2020

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