Identification of a novel cis-regulatory element essential for immune tolerance (Q36286062)

13 August 2017

Identification of a novel cis-regulatory element essential for immune tolerance (English)

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13 August 2017

cis-regulatory element

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Taylor N LaFlam

1

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13 August 2017

Grégory Seumois

2

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13 August 2017

Corey N Miller

3

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13 August 2017

Wint Lwin

4

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13 August 2017

Kayla J Fasano

5

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13 August 2017

Michael Waterfield

6

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13 August 2017

Irina Proekt

7

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13 August 2017

Pandurangan Vijayanand

8

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13 August 2017

Mark S Anderson

9

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13 August 2017

language of work or name

English

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publication date

2 November 2015

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Journal of Experimental Medicine

13 August 2017

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13 August 2017

212

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13 August 2017

12

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13 August 2017

1993-2002

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describes a project that uses

13 August 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4647269/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

Epigenomic analysis of primary human T cells reveals enhancers associated with TH2 memory cell differentiation and asthma susceptibility

1 reference

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Enhancement of an anti-tumor immune response by transient blockade of central T cell tolerance

30 September 2017

1 reference

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Genome engineering using the CRISPR-Cas9 system

30 September 2017

1 reference

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Extrathymic Aire-expressing cells are a distinct bone marrow-derived population that induce functional inactivation of CD4⁺ T cells

30 September 2017

1 reference

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Overlapping gene coexpression patterns in human medullary thymic epithelial cells generate self-antigen diversity

30 September 2017

1 reference

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High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells

30 September 2017

1 reference

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Aire-dependent thymic development of tumor-associated regulatory T cells

30 September 2017

1 reference

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Detection of an autoreactive T-cell population within the polyclonal repertoire that undergoes distinct autoimmune regulator (Aire)-mediated selection

30 September 2017

1 reference

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Post-Aire Maturation of Thymic Medullary Epithelial Cells Involves Selective Expression of Keratinocyte-Specific Autoantigens

30 September 2017

1 reference

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Histone H3K27ac separates active from poised enhancers and predicts developmental state

30 September 2017

1 reference

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Lymphotoxin signals from positively selected thymocytes regulate the terminal differentiation of medullary thymic epithelial cells

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4647269

Genomics of long-range regulatory elements

30 September 2017

1 reference

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Identification of an autoantigen demonstrates a link between interstitial lung disease and a defect in central tolerance.

30 September 2017

1 reference

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Diagnosis and management of polyendocrinopathy syndromes

30 September 2017

1 reference

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Aire-deficient C57BL/6 mice mimicking the common human 13-base pair deletion mutation present with only a mild autoimmune phenotype

30 September 2017

1 reference

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ChIP-seq accurately predicts tissue-specific activity of enhancers

30 September 2017

1 reference

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Deletional tolerance mediated by extrathymic Aire-expressing cells

30 September 2017

1 reference

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Mechanisms of an autoimmunity syndrome in mice caused by a dominant mutation in Aire

30 September 2017

1 reference

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Spontaneous autoimmunity prevented by thymic expression of a single self-antigen

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4647269

NF-kappaB2 is required for the establishment of central tolerance through an Aire-dependent pathway

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4647269

VISTA: computational tools for comparative genomics

30 September 2017

1 reference

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rVISTA 2.0: evolutionary analysis of transcription factor binding sites

30 September 2017

1 reference

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Projection of an immunological self shadow within the thymus by the aire protein

30 September 2017

1 reference

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Variegated expression of the endogenous immunoglobulin heavy-chain gene in the absence of the intronic locus control region

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4647269

An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4647269

Positional cloning of the APECED gene

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4647269

RANK signals from CD4(+)3(-) inducer cells regulate development of Aire-expressing epithelial cells in the thymic medulla

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4647269

The cytokine RANKL produced by positively selected thymocytes fosters medullary thymic epithelial cells that express autoimmune regulator.

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4647269

The tumor necrosis factor family receptors RANK and CD40 cooperatively establish the thymic medullary microenvironment and self-tolerance.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4647269

Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4647269

RNA and protein expression of the murine autoimmune regulator gene (Aire) in normal, RelB-deficient and in NOD mouse

22 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26527800

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1084/JEM.20151069

1 reference

13 August 2017

1 reference

13 August 2017

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