Therapeutic anti-integrin (alpha4 and alphaL) monoclonal antibodies: two-edged swords? (Q36291069)

13 August 2017

1 reference

title

Therapeutic anti-integrin (alpha4 and alphaL) monoclonal antibodies: two-edged swords? (English)

1 reference

13 August 2017

1 reference

María Mittelbrunn

2

0 references

Francisco Sánchez-Madrid

series ordinal

3

object named as

Francisco Sánchez-Madrid

1 reference

13 August 2017

Roberto González-Amaro

series ordinal

1

1 reference

13 August 2017

1 November 2005

1 reference

13 August 2017

1 reference

13 August 2017

116

1 reference

13 August 2017

289-296

1 reference

13 August 2017

3

1 reference

Integrins: bidirectional, allosteric signaling machines

13 August 2017

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2005.02225.X

T-cell integrins: more than just sticking points

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2005.02225.X

VCAM-1 on activated endothelium interacts with the leukocyte integrin VLA-4 at a site distinct from the VLA-4/fibronectin binding site.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2005.02225.X

Identification and characterization of the T lymphocyte adhesion receptor for an alternative cell attachment domain (CS-1) in plasma fibronectin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2005.02225.X

JAM2 interacts with alpha4beta1. Facilitation by JAM3

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2005.02225.X

The alpha 4 integrin chain is a ligand for alpha 4 beta 7 and alpha 4 beta 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2005.02225.X

The lymphocyte metalloprotease MDC-L (ADAM 28) is a ligand for the integrin alpha4beta1

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2005.02225.X

Intercellular adhesion molecule-4 binds alpha(4)beta(1) and alpha(V)-family integrins through novel integrin-binding mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2005.02225.X

Maturation-dependent expression and function of the CD49d integrin on monocyte-derived human dendritic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2005.02225.X

beta1 integrins are critically involved in neutrophil locomotion in extravascular tissue In vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2005.02225.X

Adhesion of human B cells to follicular dendritic cells involves both the lymphocyte function-associated antigen 1/intercellular adhesion molecule 1 and very late antigen 4/vascular cell adhesion molecule 1 pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2005.02225.X

alpha 4 integrins mediate lymphocyte attachment and rolling under physiologic flow

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2005.02225.X

The functional interaction of the beta 2 integrin lymphocyte function-associated antigen-1 with junctional adhesion molecule-A is mediated by the I domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2005.02225.X

Mechanisms contributing to the activity of integrins on leukocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2005.02225.X

Expression of functionally active alpha 4 beta 1 integrin by thymic epithelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2005.02225.X

Evidence for a role of the integrin VLA-4 in lympho-hemopoiesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2005.02225.X

Expression of the cell-adhesion molecule VCAM-1 by stromal cells is necessary for osteoclastogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2005.02225.X

Effects of VLA-4 antagonists in rat whole embryo culture.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2005.02225.X

VLA-4 integrin concentrates at the peripheral supramolecular activation complex of the immune synapse and drives T helper 1 responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2005.02225.X

VLA-4 mediates CD3-dependent CD4+ T cell activation via the CS1 alternatively spliced domain of fibronectin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2005.02225.X

Fibronectin-mononuclear cell interactions regulate type 1 helper T cell cytokine network in tolerant transplant recipients

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2005.02225.X

Functional alpha4-integrin: a newly identified pathway of neutrophil recruitment in critically ill septic patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2005.02225.X

Bimolecular complex between rolling and firm adhesion receptors required for cell arrest; CD44 association with VLA-4 in T cell extravasation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2005.02225.X

The in vivo cytotoxic activity of CD8+ T cell clones correlates with their levels of expression of adhesion molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2005.02225.X

Cell adhesion and polarity during immune interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2005.02225.X

The immunological synapse: integrins take the stage.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2005.02225.X

Three-dimensional segregation of supramolecular activation clusters in T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2005.02225.X

Isolation and characterization of human tonsil dendritic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2005.02225.X

Treatment with anti-LFA-1 delays the CD8+ cytotoxic-T-lymphocyte response and viral clearance in mice with primary respiratory syncytial virus infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2005.02225.X

LFA-1 contributes an early signal for NK cell cytotoxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2005.02225.X

Surface expression of alpha 4 integrin by CD4 T cells is required for their entry into brain parenchyma

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2005.02225.X

Prevention of experimental autoimmune encephalomyelitis by antibodies against alpha 4 beta 1 integrin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2005.02225.X

Potent alpha 4 beta 1 peptide antagonists as potential anti-inflammatory agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2005.02225.X

Antagonism of the alpha4 integrin subunit attenuates the acute inflammatory response to stent implantation yet is insufficient to prevent late intimal formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2005.02225.X

Pulmonary eosinophilia in a murine model of allergic inflammation is attenuated by small molecule alpha4beta1 antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2005.02225.X

Antibodies to intercellular adhesion molecule 1/lymphocyte function-associated antigen 1 prevent crescent formation in rat autoimmune glomerulonephritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2005.02225.X

Inhibition of LFA-1/ICAM-1 and VLA-4/VCAM-1 as a therapeutic approach to inflammation and autoimmune diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2005.02225.X

Therapeutic intervention with inhibitors of co-stimulatory pathways in autoimmune disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2005.02225.X

Determinants of Human B Cell Migration Across Brain Endothelial Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2005.02225.X

Differential effects of treatment with a small-molecule VLA-4 antagonist before and after onset of relapsing EAE.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2005.02225.X

Apoptosis, tolerance, and regulatory T cells--old wine, new wineskins

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2005.02225.X

LFA-1 on CD4+ T cells is required for optimal antigen-dependent activation in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2005.02225.X

Augmentation of adoptively transferred experimental allergic encephalomyelitis by administration of a monoclonal antibody specific for LFA-1 alpha.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2005.02225.X

Psoriasis as a model for T-cell-mediated disease: immunobiologic and clinical effects of treatment with multiple doses of efalizumab, an anti-CD11a antibody.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2005.02225.X

Effects of administration of a single dose of a humanized monoclonal antibody to CD11a on the immunobiology and clinical activity of psoriasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2005.02225.X

Essential role of MHC II-independent CD4+ T cells, IL-4 and STAT6 in contact hypersensitivity induced by fluorescein isothiocyanate in the mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2005.02225.X

Human CD25+ regulatory T cells: two subsets defined by the integrins alpha 4 beta 7 or alpha 4 beta 1 confer distinct suppressive properties upon CD4+ T helper cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2005.02225.X

Unusual toxicities with TNF inhibition: heart failure and drug-induced lupus.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1802423

Therapeutic value of alpha-4 integrin blockade in inflammatory bowel disease:the role of natalizumab

12 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1802423

Treatment of rheumatoid arthritis with tumor necrosis factor inhibitors may predispose to significant increase in tuberculosis risk: a multicenter active-surveillance report

12 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1802423

A new type of antimetastatic peptide derived from fibronectin.

12 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1802423

Discordant effects of anti-VLA-4 treatment before and after onset of relapsing experimental autoimmune encephalomyelitis.

12 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1802423

Cell adhesion molecules: selectins and integrins.

12 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1802423

Mobilization and homing of peripheral blood progenitors is related to reversible downregulation of alpha4 beta1 integrin expression and function

12 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1802423

Analysis of ligand-induced and ligand-attenuated epitopes on the leukocyte integrin alpha4beta1: VCAM-1, mucosal addressin cell adhesion molecule-1, and fibronectin induce distinct conformational changes

12 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1802423

A monoclonal antibody against very late activation antigen-4 inhibits eosinophil accumulation and late asthmatic response in a guinea pig model of asthma

12 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1802423

Distribution of ICAM-3-bearing cells in normal human tissues. Expression of a novel counter-receptor for LFA-1 in epidermal Langerhans cells.

12 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1802423

TNF-alpha expression by resident microglia and infiltrating leukocytes in the central nervous system of mice with experimental allergic encephalomyelitis. Regulation by Th1 cytokines

12 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1802423

Vascular adhesion molecule-1 and intercellular adhesion molecule-1 expression on rat liver cells after lipopolysaccharide administration in vivo

12 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1802423

Inhibition of T cell costimulation by VCAM-1 prevents murine graft-versus-host disease across minor histocompatibility barriers.

12 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1802423

Suppression of ICE and apoptosis in mammary epithelial cells by extracellular matrix.

12 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1802423

The pathophysiologic role of alpha 4 integrins in vivo

12 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1802423

Adhesion molecules from the LFA-1/ICAM-1,3 and VLA-4/VCAM-1 pathways on T lymphocytes and vascular endothelium in Graves' and Hashimoto's thyroid glands

12 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1802423

Adhesion through the LFA-1 (CD11a/CD18)-ICAM-1 (CD54) and the VLA-4 (CD49d)-VCAM-1 (CD106) pathways prevents apoptosis of germinal center B cells.

12 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1802423

Inhibition of insulitis and prevention of diabetes in nonobese diabetic mice by blocking L-selectin and very late antigen 4 adhesion receptors

12 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1802423

The VLA protein family. Characterization of five distinct cell surface heterodimers each with a common 130,000 molecular weight beta subunit

12 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1802423

A monoclonal antibody to the adherence-promoting leukocyte glycoprotein, CD18, reduces organ injury and improves survival from hemorrhagic shock and resuscitation in rabbits

12 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1802423

The very late antigen family of heterodimers is part of a superfamily of molecules involved in adhesion and embryogenesis

12 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1802423

VLA-3: a novel polypeptide association within the VLA molecular complex: cell distribution and biochemical characterization

12 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1802423

Anti-LFA1 monoclonal antibody (25.3) for treatment of steroid-resistant grade III-IV acute graft-versus-host disease.

12 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1802423

Prevention of murine graft-versus-host disease and bone marrow alloengraftment across the major histocompatibility barrier after donor graft preincubation with anti-LFA1 immunotoxin

12 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1802423

Effect of anti-LFA1 (CD11a) monoclonal antibodies in acute rejection in human kidney transplantation

12 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1802423

The CS5 peptide is a second site in the IIICS region of fibronectin recognized by the integrin alpha 4 beta 1. Inhibition of alpha 4 beta 1 function by RGD peptide homologues

12 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1802423

Differential utilization of ICAM-1 and VCAM-1 during the adhesion and transendothelial migration of human T lymphocytes

12 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1802423

Roles for the integrin VLA-4 and its counter receptor VCAM-1 in myogenesis

12 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1802423

α4Integrins as Therapeutic Targets in Autoimmune Disease

12 November 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2005.02225.X

21 January 2018

1 reference

12 December 2020

Cell surface marker analysis of mouse thymic dendritic cells

1 reference

12 December 2020

The effect of anti-adhesion molecule antibody on the development of collagen-induced arthritis

1 reference

12 December 2020

Lymphocyte migration across high endothelium is associated with increases in alpha 4 beta 1 integrin (VLA-4) affinity

1 reference

12 December 2020

Reduction of graft failure by a monoclonal antibody (anti-LFA-1 CD11a) after HLA nonidentical bone marrow transplantation in children with immunodeficiencies, osteopetrosis, and Fanconi's anemia: a European Group for Immunodeficiency/European Group

1 reference

12 December 2020

Adhesion receptors involved in clustering of blood dendritic cells and T lymphocytes

1 reference

12 December 2020

Administration of monoclonal antibodies against vascular cell adhesion molecule-1/very late antigen-4 abrogates predisposing autoimmune diabetes in NOD mice

1 reference

12 December 2020

Differential requirements for alpha4 integrins during fetal and adult hematopoiesis

1 reference

12 December 2020

Treatment of established adjuvant arthritis in rats with monoclonal antibody to CD18 and very late activation antigen-4 integrins suppresses neutrophil and T-lymphocyte migration to the joints and improves clinical disease

1 reference

12 December 2020

Prevention of autoimmune insulin-dependent diabetes in non-obese diabetic mice by anti-LFA-1 and anti-ICAM-1 mAb

1 reference

12 December 2020

Immunosuppression to cardiac allografts and soluble antigens by anti-vascular cellular adhesion molecule-1 and anti-very late antigen-4 monoclonal antibodies

1 reference

12 December 2020

Expression of vascular cell adhesion molecule-1 mRNA and protein in rheumatoid synovium demonstrated by in situ hybridization and immunohistochemistry

1 reference

12 December 2020

Alpha4 integrins regulate the proliferation/differentiation balance of multilineage hematopoietic progenitors in vivo

1 reference

12 December 2020

Suppression of hepatic lesions in a murine graft-versus-host reaction by antibodies against adhesion molecules

1 reference

12 December 2020

The treatment of moderate to severe psoriasis with a new anti-CD11a monoclonal antibody

1 reference

12 December 2020

Blockade of late-phase airway responses and airway hyperresponsiveness in allergic sheep with a small-molecule peptide inhibitor of VLA-4

1 reference

12 December 2020

Regulation by differential development of Th1 and Th2 cells in peripheral tolerance to cardiac allograft induced by blocking ICAM-1/LFA-1 adhesion

1 reference

12 December 2020

Intra-epithelial subpopulations of T lymphocytes and Langerhans cells in oral lichen planus

1 reference

12 December 2020

Differential Th1 and Th2 cell regulation of murine cardiac allograft acceptance by blocking cell adhesion of ICAM-1/LFA-1 and VCAM-1/VLA-4

1 reference

12 December 2020

1 reference

12 December 2020

Immunology of multiple sclerosis

1 reference

12 December 2020

Intercellular Adhesion Molecule-1/LFA-1 Ligation Favors Human Th1 Development

1 reference

12 December 2020

Stimulation through intercellular adhesion molecule-1 provides a second signal for T cell activation

1 reference

12 December 2020

Natalizumab for Relapsing Multiple Sclerosis

1 reference

12 December 2020

Natalizumab for Active Crohn's Disease

1 reference

12 December 2020

The effects of an anti-CD11a mAb, efalizumab, on allergen-induced airway responses and airway inflammation in subjects with atopic asthma

1 reference

12 December 2020

A novel targeted T-cell modulator, efalizumab, for plaque psoriasis

1 reference

12 December 2020

10.1111/J.1365-2567.2005.02225.X

Identifiers

DOI

1 reference

13 August 2017

0 references

1 reference

PubMed ID

16236118