Proprotein convertases furin and PC5: targeting atherosclerosis and restenosis at multiple levels (Q36294863)

13 August 2017

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title

Proprotein convertases furin and PC5: targeting atherosclerosis and restenosis at multiple levels (English)

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13 August 2017

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Philipp Stawowy

1

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PubMed ID

16244876

13 August 2017

Eckart Fleck

series ordinal

2

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13 August 2017

22 October 2005

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Journal of Molecular Medicine

13 August 2017

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13 August 2017

83

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13 August 2017

11

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13 August 2017

865-875

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https://scigraph.springernature.com/pub.10.1007/s00109-005-0723-8

13 August 2017

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21 January 2018

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Upregulatory expression of furin and transforming growth factor-beta by fluid shear stress in vascular endothelial cells

21 January 2018

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Selective expression of the proprotein convertases furin, pc5, and pc7 in proliferating vascular smooth muscle cells of the rat aorta in vitro

21 January 2018

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Furin and proprotein convertase 7 (PC7)/lymphoma PC endogenously expressed in rat liver can be resolved into distinct post-Golgi compartments

21 January 2018

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Role of Monocytes in Atherogenesis

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The extracellular matrix as a cell survival factor

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Inhibition of vascular smooth muscle cell growth by inhibition of fibronectin matrix assembly

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Regulation of membrane type-1 matrix metalloproteinase activation by proprotein convertases

21 January 2018

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Beta3-integrins rather than beta1-integrins dominate integrin-matrix interactions involved in postinjury smooth muscle cell migration.

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Selective alpha(v)beta(3)-receptor blockade reduces macrophage infiltration and restenosis after balloon angioplasty in the atherosclerotic rabbit

21 January 2018

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Autophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2-dependent binding of pp60src

21 January 2018

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Cytokine-stimulated human vascular smooth muscle cells synthesize a complement of enzymes required for extracellular matrix digestion

21 January 2018

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Membrane type 1 matrix metalloproteinase expression in human atherosclerotic plaques: evidence for activation by proinflammatory mediators

21 January 2018

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Oxidized low-density lipoprotein regulates matrix metalloproteinase-9 and its tissue inhibitor in human monocyte-derived macrophages.

21 January 2018

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Activation of MMP-2 in response to vascular injury is mediated by phosphatidylinositol 3-kinase-dependent expression of MT1-MMP.

21 January 2018

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Ontogeny of the prohormone convertases PC1 and PC2 in the mouse hypophysis and their colocalization with corticotropin and alpha-melanotropin

21 January 2018

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12 December 2020

Human monocyte-derived macrophages induce collagen breakdown in fibrous caps of atherosclerotic plaques. Potential role of matrix-degrading metalloproteinases and implications for plaque rupture

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12 December 2020

In vitro characterization of the novel proprotein convertase PC7.

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12 December 2020

cDNA structure, tissue distribution, and chromosomal localization of rat PC7, a novel mammalian proprotein convertase closest to yeast kexin-like proteinases

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12 December 2020

Implications of proprotein Convertase 5 (PC5) in the arterial restenotic process in a porcine model.

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12 December 2020

Inhibition of growth factor-induced protein synthesis by a selective MEK inhibitor in aortic smooth muscle cells

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12 December 2020

Cleavage of the alpha6A subunit is essential for activation of the alpha6Abeta1 integrin by phorbol 12-myristate 13-acetate

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12 December 2020

Vascular proliferation and atherosclerosis: new perspectives and therapeutic strategies.

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12 December 2020

Processing of integrin alpha(v) subunit by membrane type 1 matrix metalloproteinase stimulates migration of breast carcinoma cells on vitronectin and enhances tyrosine phosphorylation of focal adhesion kinase

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12 December 2020

Association of focal adhesion kinase with its potential substrate phosphatidylinositol 3-kinase

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12 December 2020

Disruption of PC1/3 expression in mice causes dwarfism and multiple neuroendocrine peptide processing defects

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12 December 2020

The adhesive and migratory effects of osteopontin are mediated via distinct cell surface integrins. Role of alpha v beta 3 in smooth muscle cell migration to osteopontin in vitro

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12 December 2020

The crystal structure of the proprotein processing proteinase furin explains its stringent specificity

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12 December 2020

A role for the alphavbeta3 integrin in the transmigration of monocytes

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12 December 2020

Impaired fertility in mice deficient for the testicular germ-cell protease PC4

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12 December 2020

Molecular basis of restenosis and drug-eluting stents

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12 December 2020

Osteopontin mRNA is expressed by smooth muscle-derived foam cells in human atherosclerotic lesions of the aorta

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12 December 2020

cDNA and amino acid sequences of the cell adhesion protein receptor recognizing vitronectin reveal a transmembrane domain and homologies with other adhesion protein receptors

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12 December 2020

Targeting the molecular target of rapamycin (mTOR).

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12 December 2020

Stimulation of cell migration by overexpression of focal adhesion kinase and its association with Src and Fyn

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12 December 2020

Inhibition of intimal thickening after balloon angioplasty in porcine coronary arteries by targeting regulators of the cell cycle

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12 December 2020

Matrix metalloproteinase and alphavbeta3 integrin-dependent vascular smooth muscle cell invasion through a type I collagen lattice

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12 December 2020

Regulation of matrix metalloproteinase MT1-MMP/MMP-2 in cardiac fibroblasts by TGF-beta1 involves furin-convertase

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12 December 2020

Proprotein convertases and the pathophysiology of human diseases: prospective considerations

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12 December 2020

α v β 3 Integrin Expression in Normal and Atherosclerotic Artery

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12 December 2020

Vitronectin expression and interaction with receptors in smooth muscle cells from human atheromatous plaque

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12 December 2020

A signaling role for the uncleaved form of alpha 6 integrin in differentiating lens fiber cells

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12 December 2020

Proprotein convertases regulate insulin-like growth factor 1-induced membrane-type 1 matrix metalloproteinase in VSMCs via endoproteolytic activation of the insulin-like growth factor-1 receptor

1 reference

12 December 2020

Regulation of differentiation of vascular smooth muscle cells

1 reference

12 December 2020

Membrane type-1 matrix metalloproteinase functions as a proprotein self-convertase. Expression of the latent zymogen in Pichia pastoris, autolytic activation, and the peptide sequence of the cleavage forms

1 reference

12 December 2020

Vitronectin is up-regulated after vascular injury and vitronectin blockade prevents neointima formation

1 reference

12 December 2020

Endoproteolytic processing of integrin pro-alpha subunits involves the redundant function of furin and proprotein convertase (PC) 5A, but not paired basic amino acid converting enzyme (PACE) 4, PC5B or PC7

1 reference

12 December 2020

Furin and membrane type-1 metalloproteinase mRNA levels and activation of metalloproteinase-2 are associated with arterial remodeling

1 reference

12 December 2020

Increased expression of matrix metalloproteinases and matrix degrading activity in vulnerable regions of human atherosclerotic plaques

1 reference

12 December 2020

Extracellular matrix modulates macrophage functions characteristic to atheroma: collagen type I enhances acquisition of resident macrophage traits by human peripheral blood monocytes in vitro

1 reference

12 December 2020

Kex2 family endoprotease furin is expressed specifically in pit-region parietal cells of the rat gastric mucosa.

1 reference

12 December 2020

Inhibition of proprotein convertases is associated with loss of growth and tumorigenicity of HT-29 human colon carcinoma cells: importance of insulin-like growth factor-1 (IGF-1) receptor processing in IGF-1-mediated functions

1 reference

12 December 2020

Curbing activation: proprotein convertases in homeostasis and pathology

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12 December 2020

NARC-1/PCSK9 and its natural mutants: zymogen cleavage and effects on the low density lipoprotein (LDL) receptor and LDL cholesterol

1 reference

12 December 2020

Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry

1 reference

12 December 2020

Functional structure and composition of the extracellular matrix

1 reference

12 December 2020

Expression of a protein tyrosine phosphatase in normal and v-src-transformed mouse 3T3 fibroblasts

1 reference

12 December 2020

Inhibition of furin-mediated cleavage activation of HIV-1 glycoprotein gp160

1 reference

12 December 2020

Impaired flow-induced dilation in mesenteric resistance arteries from receptor protein tyrosine phosphatase-mu-deficient mice

1 reference

12 December 2020

Membrane-type metalloproteinases in tumor invasion

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12 December 2020

Inflammation dampened by gelatinase A cleavage of monocyte chemoattractant protein-3

1 reference

12 December 2020

Fibrillar collagen inhibits arterial smooth muscle proliferation through regulation of Cdk2 inhibitors

1 reference

12 December 2020

Localization of furin to the trans-Golgi network and recycling from the cell surface involves Ser and Tyr residues within the cytoplasmic domain.

1 reference

12 December 2020

Furin at the cutting edge: from protein traffic to embryogenesis and disease

1 reference

12 December 2020

Matrix metalloproteinase-2 is an interstitial collagenase. Inhibitor-free enzyme catalyzes the cleavage of collagen fibrils and soluble native type I collagen generating the specific 3/4- and 1/4-length fragments.

1 reference

12 December 2020

Integrin-mediated activation of MAP kinase is independent of FAK: evidence for dual integrin signaling pathways in fibroblasts

1 reference

12 December 2020

Membrane type 4 matrix metalloproteinase (MMP17) has tumor necrosis factor-alpha convertase activity but does not activate pro-MMP2.

1 reference

12 December 2020

Role of nuclear factor-kappa B activation in metalloproteinase-1, -3, and -9 secretion by human macrophages in vitro and rabbit foam cells produced in vivo

1 reference

12 December 2020

Localization of matrix metalloproteinase MMP-2 to the surface of invasive cells by interaction with integrin alpha v beta 3.

1 reference

12 December 2020

Proprotein and prohormone convertases: a family of subtilases generating diverse bioactive polypeptides

1 reference

12 December 2020

Furin inhibition results in absent or decreased invasiveness and tumorigenicity of human cancer cells

1 reference

12 December 2020

Proprotein convertase PC5 regulation by PDGF-BB involves PI3-kinase/p70(s6)-kinase activation in vascular smooth muscle cells

1 reference

12 December 2020

Role of endoproteolytic processing in the adhesive and signaling functions of alphavbeta5 integrin

1 reference

12 December 2020

Human carcinoma cell growth and invasiveness is impaired by the propeptide of the ubiquitous proprotein convertase furin

1 reference

12 December 2020

Cross-talk between the p42/p44 MAP kinase and Smad pathways in transforming growth factor beta 1-induced furin gene transactivation

1 reference

12 December 2020

Latent TGF-beta1 activation by platelets

1 reference

12 December 2020

Coordinated regulation and colocalization of alphav integrin and its activating enzyme proprotein convertase PC5 in vivo.

1 reference

12 December 2020

Induction of cell migration by matrix metalloprotease-2 cleavage of laminin-5

1 reference

12 December 2020

Endoproteolytic activation of alpha(v) integrin by proprotein convertase PC5 is required for vascular smooth muscle cell adhesion to vitronectin and integrin-dependent signaling

1 reference

12 December 2020

Inhibition of alpha4 integrin and ICAM-1 markedly attenuate macrophage homing to atherosclerotic plaques in ApoE-deficient mice

1 reference

12 December 2020

Mammalian subtilisin/kexin isozyme SKI-1: A widely expressed proprotein convertase with a unique cleavage specificity and cellular localization

1 reference

12 December 2020

MCP-1 deficiency reduces susceptibility to atherosclerosis in mice that overexpress human apolipoprotein B.

1 reference

12 December 2020

Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesis

1 reference

12 December 2020

MT1-MMP initiates activation of pro-MMP-2 and integrin alphavbeta3 promotes maturation of MMP-2 in breast carcinoma cells

1 reference

12 December 2020

Furin-independent pathway of membrane type 1-matrix metalloproteinase activation in rabbit dermal fibroblasts.

1 reference

12 December 2020

Vitaxin, a humanized monoclonal antibody to the vitronectin receptor (alphavbeta3), reduces neointimal hyperplasia and total vessel area after balloon injury in hypercholesterolemic rabbits

1 reference

12 December 2020

Dual role of matrix metalloproteinases (matrixins) in intimal thickening and atherosclerotic plaque rupture

1 reference

12 December 2020

Membrane-type matrix metalloproteinase-1 and -3 activity in primate smooth muscle cells.

1 reference

12 December 2020

Furin-like proprotein convertases are central regulators of the membrane type matrix metalloproteinase-pro-matrix metalloproteinase-2 proteolytic cascade in atherosclerosis.

1 reference

12 December 2020

Neutral metalloproteinases produced by human mononuclear phagocytes. Enzyme profile, regulation, and expression during cellular development

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12 December 2020

Atherosclerosis — An Inflammatory Disease

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12 December 2020

Peripheral blood levels of matrix metalloproteases-2 and -9 are elevated in patients with acute coronary syndromes

1 reference

12 December 2020

Requirement of phosphatidylinositol 3-kinase in focal adhesion kinase-promoted cell migration

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12 December 2020

Alpha1-antitrypsin Portland inhibits processing of precursors mediated by proprotein convertases primarily within the constitutive secretory pathway

1 reference

12 December 2020

Failure of ventral closure and axial rotation in embryos lacking the proprotein convertase Furin.

1 reference

12 December 2020

The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): liver regeneration and neuronal differentiation

1 reference

12 December 2020

The soluble catalytic domain of membrane type 1 matrix metalloproteinase cleaves the propeptide of progelatinase A and initiates autoproteolytic activation. Regulation by TIMP-2 and TIMP-3.

1 reference

12 December 2020

Increased proteolytic processing of protein tyrosine phosphatase mu in confluent vascular endothelial cells: the role of PC5, a member of the subtilisin family

1 reference

12 December 2020

Migration of cultured vascular smooth muscle cells through a basement membrane barrier requires type IV collagenase activity and is inhibited by cellular differentiation

1 reference

12 December 2020

Immunohistochemical localization of subtilisin/kexin-like proprotein convertases in human atherosclerosis.

1 reference

12 December 2020

Angiotensin II-accelerated atherosclerosis and aneurysm formation is attenuated in osteopontin-deficient mice

1 reference

12 December 2020

Molecular identification of the sterol-regulated luminal protease that cleaves SREBPs and controls lipid composition of animal cells

1 reference

12 December 2020

Activation of membrane-type matrix metalloproteinase 3 zymogen by the proprotein convertase furin in the trans-Golgi network

1 reference

12 December 2020

Integrins: versatility, modulation, and signaling in cell adhesion

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12 December 2020

Temporally and spatially coordinated expression of cell cycle regulatory factors after angioplasty

1 reference

12 December 2020

Metalloproteinase expression in PMA-stimulated THP-1 cells. Effects of peroxisome proliferator-activated receptor-gamma (PPAR gamma) agonists and 9-cis-retinoic acid.

1 reference

12 December 2020

Mechanism of cell surface activation of 72-kDa type IV collagenase. Isolation of the activated form of the membrane metalloprotease

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12 December 2020

Regulation of vascular smooth muscle cell migration and proliferation in vitro and in injured rat arteries by a synthetic matrix metalloproteinase inhibitor

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12 December 2020

Membrane type 1-matrix metalloproteinase is involved in migration of human monocytes and is regulated through their interaction with fibronectin or endothelium

1 reference

12 December 2020

Nerve growth factor and proprotein convertases furin and PC7 in transected sciatic nerves and in nerve segments cultured in conditioned media: their presence in Schwann cells, macrophages, and smooth muscle cells

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12 December 2020

Intracoronary brachytherapy--clinical state and pathophysiological considerations

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12 December 2020

Integrin regulation of cell signalling and motility.

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12 December 2020

Modified low density lipoprotein and its constituents augment cytokine-activated vascular cell adhesion molecule-1 gene expression in human vascular endothelial cells

1 reference

12 December 2020

Protection against anthrax toxemia by hexa-D-arginine in vitro and in vivo

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12 December 2020

Osteopontin deficiency in rat vascular smooth muscle cells is associated with an inability to adhere to collagen and increased apoptosis

1 reference

12 December 2020

Specific abrogation of transforming growth factor-beta signaling in T cells alters atherosclerotic lesion size and composition in mice

1 reference

12 December 2020

10.1007/S00109-005-0723-8

Identifiers

DOI

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13 August 2017

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PubMed ID

16244876