Dimebon alters hippocampal amyloid pathology in 3xTg-AD mice. (Q36304050)

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15 February 2020

title

Dimebon alters hippocampal amyloid pathology in 3xTg-AD mice (English)

1 reference

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15 February 2020

8

Elliott J Mufson

1 reference

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15 February 2020

1

Sylvia E Perez

1 reference

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15 February 2020

5

Christy M Kelley

1 reference

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15 February 2020

6

Scott E Counts

1 reference

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15 February 2020

author name string

Muhammad Nadeem

2

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15 February 2020

Katherine R Sadleir

3

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15 February 2020

Joanna Matras

4

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15 February 2020

Robert Vassar

7

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15 February 2020

publication date

20 September 2012

1 reference

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International journal of physiology, pathophysiology and pharmacology

15 February 2020

published in

1 reference

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15 February 2020

volume

4

1 reference

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15 February 2020

issue

3

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15 February 2020

page(s)

115-127

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Mitochondrial Ca(2+) and apoptosis

15 February 2020

cites work

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Dimebon ameliorates amyloid-β induced impairments of mitochondrial form and function

30 September 2017

1 reference

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Alzheimer's - Looking beyond plaques

30 September 2017

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The acute effects of dimebolin, a potential Alzheimer's disease treatment, on working memory in rhesus monkeys

30 September 2017

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Preclinical study of dimebon on β-amyloid-mediated neuropathology in Alzheimer's disease

30 September 2017

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Astrocyte-neuron metabolic relationships: for better and for worse

30 September 2017

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Cholinotrophic basal forebrain system alterations in 3xTg-AD transgenic mice

30 September 2017

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Staging of Alzheimer's pathology in triple transgenic mice: a light and electron microscopic analysis

30 September 2017

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Dimebon (latrepirdine) enhances mitochondrial function and protects neuronal cells from death

30 September 2017

1 reference

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Conformations and biological activities of amyloid beta peptide 25-35.

30 September 2017

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30 September 2017

1 reference

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Noradrenaline activation of neurotrophic pathways protects against neuronal amyloid toxicity

30 September 2017

1 reference

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Acute dosing of latrepirdine (Dimebon), a possible Alzheimer therapeutic, elevates extracellular amyloid-beta levels in vitro and in vivo

30 September 2017

1 reference

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Dimebolin is a 5-HT6 antagonist with acute cognition enhancing activities

30 September 2017

1 reference

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Evaluation of Dimebon in cellular model of Huntington's disease

30 September 2017

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Effect of dimebon on cognition, activities of daily living, behaviour, and global function in patients with mild-to-moderate Alzheimer's disease: a randomised, double-blind, placebo-controlled study

30 September 2017

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Multiple role of histamine H1-receptor-PKC-MAPK signalling pathway in histamine-stimulated nerve growth factor synthesis and secretion

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A new strategy for analysis of phenotype marker antigens in hollow neurospheres

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Comparative study of action mechanisms of dimebon and memantine on AMPA- and NMDA-subtypes glutamate receptors in rat cerebral neurons

30 September 2017

1 reference

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Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction

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Mitochondria as a target for neurotoxins and neuroprotective agents

30 September 2017

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Interleukin-1 mediates pathological effects of microglia on tau phosphorylation and on synaptophysin synthesis in cortical neurons through a p38-MAPK pathway

30 September 2017

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Antihistamine agent Dimebon as a novel neuroprotector and a cognition enhancer

30 September 2017

1 reference

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Dimebon improves learning in animals with experimental Alzheimer's disease

30 September 2017

1 reference

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Action of dimebon on histamine receptors

30 September 2017

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Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease

30 September 2017

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Interleukin 1 regulates synthesis of amyloid beta-protein precursor mRNA in human endothelial cells

30 September 2017

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30 September 2017

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Reduction in p140-TrkA receptor protein within the nucleus basalis and cortex in Alzheimer's disease

30 September 2017

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The 5HT5A serotonin receptor is expressed predominantly by astrocytes in which it inhibits cAMP accumulation: a mechanism for neuronal suppression of reactive astrocytes.

29 June 2018

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Characterization of ameboid microglia isolated from developing mammalian brain.

29 June 2018

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Demonstration of Amyloid Deposits and Neurofibrillary Changes in Whole Brain Sections

29 June 2018

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Dimebon enhances hippocampus-dependent learning in both appetitive and inhibitory memory tasks in mice

29 June 2018

1 reference

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Liquid chromatography-tandem mass spectrometry method for the quantification of dimebon in rat plasma and brain tissue.

22 September 2018

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22 September 2018

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22 September 2018

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Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer's disease.

22 September 2018

1 reference

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Self-assembly of Abeta(1-42) into globular neurotoxins.

22 September 2018

1 reference

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Astrocytes accumulate Aβ42 and give rise to astrocytic amyloid plaques in Alzheimer disease brains

22 September 2018

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Phases of A beta-deposition in the human brain and its relevance for the development of AD.

22 September 2018

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22 September 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/23071869

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Expression of a dominant-negative mutant of p21(ras) inhibits induction of nitric oxide synthase and activation of nuclear factor-kappaB in primary astrocytes

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23071869

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

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15 February 2020

1 reference