Single-molecule view of basal activity and activation mechanisms of the G protein-coupled receptor β2AR. (Q36306077)

13 August 2017

Single-molecule view of basal activity and activation mechanisms of the G protein-coupled receptor β2AR. (English)

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G protein-coupled receptor

13 August 2017

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Rajan Lamichhane

1

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Vsevolod Katritch

object named as

Vsevolod Katritch

6

0 references

Kurt Wüthrich

8

object named as

Kurt Wüthrich

1 reference

13 August 2017

Jeffrey J Liu

2

1 reference

13 August 2017

Goran Pljevaljcic

3

1 reference

13 August 2017

Kate L White

4

1 reference

13 August 2017

Edwin van der Schans

5

1 reference

13 August 2017

Raymond C Stevens

7

1 reference

13 August 2017

David P Millar

9

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13 August 2017

language of work or name

English

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publication date

2 November 2015

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Proceedings of the National Academy of Sciences of the United States of America

13 August 2017

1 reference

13 August 2017

112

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13 August 2017

46

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13 August 2017

14254-14259

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Conformational dynamics of a class C G-protein-coupled receptor

13 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4655547

Structural Insights into the Dynamic Process of β2-Adrenergic Receptor Signaling

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4655547

Protein induced fluorescence enhancement (PIFE) for probing protein-nucleic acid interactions

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4655547

The role of ligands on the equilibria between functional states of a G protein-coupled receptor

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4655547

Dynamics of site switching in DNA polymerase.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4655547

The dynamic process of β(2)-adrenergic receptor activation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4655547

Efficacy of the β₂-adrenergic receptor is determined by conformational equilibrium in the transmembrane region

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4655547

Single-molecule Förster resonance energy transfer reveals an innate fidelity checkpoint in DNA polymerase I

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4655547

Activation mechanism of the β2-adrenergic receptor

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4655547

Conformational dynamics of single G protein-coupled receptors in solution

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4655547

Crystal structure of the β2 adrenergic receptor-Gs protein complex

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4655547

Protein induced fluorescence enhancement as a single molecule assay with short distance sensitivity

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4655547

Single-molecule FRET of protein-nucleic acid and protein-protein complexes: surface passivation and immobilization

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4655547

Chapter 11 - Reconstitution of membrane proteins in phospholipid bilayer nanodiscs

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4655547

Membrane protein assembly into Nanodiscs

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4655547

The effect of ligand efficacy on the formation and stability of a GPCR-G protein complex

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4655547

Stabilization of the human beta2-adrenergic receptor TM4-TM3-TM5 helix interface by mutagenesis of Glu122(3.41), a critical residue in GPCR structure

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4655547

High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4655547

A monomeric G protein-coupled receptor isolated in a high-density lipoprotein particle efficiently activates its G protein

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4655547

Analysis of single-molecule FRET trajectories using hidden Markov modeling

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4655547

Functional reconstitution of Beta2-adrenergic receptors utilizing self-assembling Nanodisc technology

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4655547

Constitutive activity and inverse agonists of G protein-coupled receptors: a current perspective

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4655547

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4655547

Single-molecule spectroscopy of the beta(2) adrenergic receptor: observation of conformational substates in a membrane protein

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4655547

Agonist-induced conformational changes in the G-protein-coupling domain of the beta 2 adrenergic receptor

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4655547

Physiological effects of inverse agonists in transgenic mice with myocardial overexpression of the beta 2-adrenoceptor

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4655547

Biased signaling pathways in β2-adrenergic receptor characterized by 19F-NMR.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4655547

Differential signaling of the endogenous agonists at the beta2-adrenergic receptor

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4655547

Demystifying PIFE: The Photophysics Behind the Protein-Induced Fluorescence Enhancement Phenomenon in Cy3.

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4655547

β₂-adrenergic receptor activation by agonists studied with ¹⁹F NMR spectroscopy

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4655547

The selectivity of beta-adrenoceptor agonists at human beta1-, beta2- and beta3-adrenoceptors

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4655547

Functionally different agonists induce distinct conformations in the G protein coupling domain of the beta 2 adrenergic receptor

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4655547

Fine tuning of sub-millisecond conformational dynamics controls metabotropic glutamate receptors agonist efficacy

22 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.1519626112

21 January 2018

Identifiers

DOI

10.1073/PNAS.1519626112

1 reference

13 August 2017

0 references

1 reference

13 August 2017

PubMed publication ID

26578769

1 reference