Flavin-containing monooxygenase genetic polymorphism: impact on chemical metabolism and drug development. (Q36316996)

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9 January 2020

review article

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title

Flavin-containing monooxygenase genetic polymorphism: impact on chemical metabolism and drug development (English)

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9 January 2020

2

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9 January 2020

author name string

Sevasti B Koukouritaki

series ordinal

1

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publication date

1 December 2005

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9 January 2020

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9 January 2020

volume

6

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9 January 2020

issue

8

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9 January 2020

page(s)

807-822

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The distinct nature and function of NADPH-cytochrome c reductase and the NADPH-dependent mixed-function amine oxidase of porcine liver microsomes.

9 January 2020

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A nomenclature for the mammalian flavin-containing monooxygenase gene family based on amino acid sequence identities

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The molecular biology of the flavin-containing monooxygenases of man

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Alternative processing of the human FMO6 gene renders transcripts incapable of encoding a functional flavin-containing monooxygenase

21 January 2018

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Organization and evolution of the flavin-containing monooxygenase genes of human and mouse: identification of novel gene and pseudogene clusters.

21 January 2018

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An overview of the mechanism, substrate specificities, and structure of FMOs

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Tertiary amines related to brompheniramine: preferred conformations for N-oxygenation by the hog liver flavin-containing monooxygenase

21 January 2018

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Stereoselective metabolism of (S)-(-)-nicotine in humans: formation of trans-(S)-(-)-nicotine N-1'-oxide

21 January 2018

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Phenotypes of flavin-containing monooxygenase activity determined by ranitidine N-oxidation are positively correlated with genotypes of linked FM03 gene mutations in a Korean population

21 January 2018

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Expression and characterization of a modified flavin-containing monooxygenase 4 from humans

21 January 2018

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Differential developmental and tissue-specific regulation of expression of the genes encoding three members of the flavin-containing monooxygenase family of man, FMO1, FMO3 and FM04

21 January 2018

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Characterization of flavin-containing monooxygenase 5 (FMO5) cloned from human and guinea pig: evidence that the unique catalytic properties of FMO5 are not confined to the rabbit ortholog

21 January 2018

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Quantitation and kinetic properties of hepatic microsomal and recombinant flavin-containing monooxygenases 3 and 5 from humans

21 January 2018

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Human kidney flavin-containing monooxygenases and their potential roles in cysteine s-conjugate metabolism and nephrotoxicity.

21 January 2018

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Human hepatic flavin-containing monooxygenases 1 (FMO1) and 3 (FMO3) developmental expression

21 January 2018

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Molecular cloning of the flavin-containing monooxygenase (form II) cDNA from adult human liver

21 January 2018

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Further characterization of the major and minor rabbit FMO1 promoters and identification of both positive and negative distal regulatory elements

21 January 2018

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Identification of novel variants of the flavin-containing monooxygenase gene family in African Americans

21 January 2018

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Evaluation of xenobiotic N- and S-oxidation by variant flavin-containing monooxygenase 1 (FMO1) enzymes

21 January 2018

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Genetic variability at the human FMO1 locus: significance of a basal promoter yin yang 1 element polymorphism (FMO1*6)

21 January 2018

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Alternative processing events in human FMO genes

21 January 2018

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Amino acid substitution matrices from protein blocks

21 January 2018

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Pulmonary flavin-containing monooxygenase (FMO) in rhesus macaque: expression of FMO2 protein, mRNA and analysis of the cDNA.

21 January 2018

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The flavin-containing monooxygenase 2 gene (FMO2) of humans, but not of other primates, encodes a truncated, nonfunctional protein

21 January 2018

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Haplotype and functional analysis of four flavin-containing monooxygenase isoform 2 (FMO2) polymorphisms in Hispanics

21 January 2018

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Ethnic differences in human flavin-containing monooxygenase 2 (FMO2) polymorphisms: detection of expressed protein in African-Americans

21 January 2018

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Analysis of the accuracy and implications of simple methods for predicting the secondary structure of globular proteins

21 January 2018

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Identification of active flavin-containing monooxygenase isoform 2 in human lung and characterization of expressed protein

21 January 2018

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Genetic polymorphisms of flavin-containing monooxygenase (FMO).

21 January 2018

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Differences in FMO2*1 allelic frequency between Hispanics of Puerto Rican and Mexican descent

21 January 2018

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Interindividual differences of human flavin-containing monooxygenase 3: genetic polymorphisms and functional variation

21 January 2018

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Missense mutation in flavin-containing mono-oxygenase 3 gene, FMO3, underlies fish-odour syndrome

21 January 2018

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A novel deletion in the flavin-containing monooxygenase gene (FMO3) in a Greek patient with trimethylaminuria

21 January 2018

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Deleterious mutations in the flavin-containing monooxygenase 3 (FMO3) gene causing trimethylaminuria

21 January 2018

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Compound heterozygosity for missense mutations in the flavin-containing monooxygenase 3 (FM03) gene in patients with fish-odour syndrome.

21 January 2018

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Human flavin-containing monooxygenase form 3: cDNA expression of the enzymes containing amino acid substitutions observed in individuals with trimethylaminuria.

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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In vivo variability of TMA oxidation is partially mediated by polymorphisms of the FMO3 gene

21 January 2018

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Ethnic differences in allelic frequency of two flavin-containing monooxygenase 3 (FMO3) polymorphisms: linkage and effects on in vivo and in vitro FMO activities

21 January 2018

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Genetic polymorphisms of human flavin monooxygenase 3 in sulindac-mediated primary chemoprevention of familial adenomatous polyposis

21 January 2018

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Stereoselective sulfoxidation of sulindac sulfide by flavin-containing monooxygenases. Comparison of human liver and kidney microsomes and mammalian enzymes

21 January 2018

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Human flavin-containing monooxygenase (form 3): polymorphisms and variations in chemical metabolism

21 January 2018

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A mutation in the flavin-containing monooxygenase 3 gene and its effects on catalytic activity for N-oxidation of trimethylamine in vitro

21 January 2018

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Developmental expression of the major human hepatic CYP3A enzymes

21 January 2018

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21 January 2018

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21 January 2018

Identifiers

DOI

10.2217/14622416.6.8.807

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16296944%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

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