Pathogenesis, clinical features, and neurological outcome of cerebral malaria (Q36317580)

13 August 2017

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title

Pathogenesis, clinical features, and neurological outcome of cerebral malaria (English)

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13 August 2017

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Richard Idro

1

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author name string

Neil E Jenkins

series ordinal

2

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PubMed ID

16297841

13 August 2017

Charles R J C Newton

series ordinal

3

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13 August 2017

1 December 2005

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13 August 2017

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13 August 2017

4

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13 August 2017

12

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13 August 2017

827-840

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The global distribution of clinical episodes of Plasmodium falciparum malaria

13 August 2017

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7 January 2021

Indicators of life-threatening malaria in African children

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7 January 2021

Severe falciparum malaria in children: current understanding of pathophysiology and supportive treatment.

1 reference

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7 January 2021

Association of transmission intensity and age with clinical manifestations and case fatality of severe Plasmodium falciparum malaria

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7 January 2021

Seizures and status epilepticus in childhood cerebral malaria.

1 reference

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7 January 2021

Cerebral malaria: clinical features, pathophysiology and treatment

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7 January 2021

Association of hepatomegaly and jaundice with acute renal failure but not with cerebral malaria in severe falciparum malaria in Thailand.

1 reference

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7 January 2021

Intracranial hypertension in Africans with cerebral malaria

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7 January 2021

Intracranial pressure in African children with cerebral malaria.

1 reference

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7 January 2021

Prognostic significance and course of retinopathy in children with severe malaria

1 reference

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7 January 2021

Brain swelling and ischaemia in Kenyans with cerebral malaria

1 reference

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7 January 2021

Hypoglycaemia on and after admission in Kenyan children with severe malaria.

1 reference

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7 January 2021

Hyponatraemia and dehydration in severe malaria.

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7 January 2021

Acidosis in severe childhood malaria.

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7 January 2021

Immediate outcome and prognostic factors for cerebral malaria among children admitted to Mulago Hospital, Uganda

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7 January 2021

Clinical features and outcome of severe malaria in Gambian children

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7 January 2021

Hypokalemia in children with severe falciparum malaria

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7 January 2021

Severe falciparum malaria: An important cause of multiple organ failure in Indian intensive care unit patients

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7 January 2021

The pathophysiologic and prognostic significance of acidosis in severe adult malaria.

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7 January 2021

Severe Hypoglycemia and Hyperinsulinemia in Falciparum Malaria

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7 January 2021

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970247-7

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7 January 2021

Complications and mortality patterns due to Plasmodium falciparum malaria in hospitalized adults and children, Rourkela, Orissa, India.

1 reference

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7 January 2021

The incidence and outcome of neurological abnormalities in childhood cerebral malaria: a long-term follow-up of 62 survivors

1 reference

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7 January 2021

Residual neurologic sequelae after childhood cerebral malaria

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970247-7

7 January 2021

Electroencephalographic and clinical features of cerebral malaria

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970247-7

7 January 2021

Epileptic seizures and malaria in Kenyan children

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970247-7

7 January 2021

Abnormal respiratory patterns in childhood cerebral malaria

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970247-7

7 January 2021

Neurological sequelae of cerebral malaria in children

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970247-7

7 January 2021

Cognitive sequelae of severe malaria with impaired consciousness.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970247-7

7 January 2021

Convulsions with malaria: febrile or indicative of cerebral involvement?

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970247-7

7 January 2021

Chloroquine is not a risk factor for seizures in childhood cerebral malaria

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970247-7

7 January 2021

Antibodies to voltage-gated calcium channels in children with falciparum malaria

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970247-7

7 January 2021

Decorticate, decerebrate and opisthotonic posturing and seizures in Kenyan children with cerebral malaria

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970247-7

7 January 2021

Retinal findings predictive of outcome in cerebral malaria.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970247-7

7 January 2021

Lactic acidosis and hypoglycaemia in children with severe malaria: pathophysiological and prognostic significance

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970247-7

7 January 2021

Severe P. falciparum malaria in Kenyan children: evidence for hypovolaemia

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970247-7

7 January 2021

Response to volume resuscitation in children with severe malaria.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970247-7

7 January 2021

Arginine vasopressin secretion in Kenyan children with severe malaria.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970247-7

7 January 2021

Bacteraemia complicating severe malaria in children.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970247-7

7 January 2021

Bacteraemia in cerebral malaria

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970247-7

7 January 2021

Retinal Hemorrhage, A Common Sign of Prognostic Significance in Cerebral Malaria *

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970247-7

7 January 2021

Thiamine deficiency and malaria in adults from southeast Asia

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970247-7

7 January 2021

Cerebral venous and dural sinus thrombosis in severe falciparum malaria

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970247-7

7 January 2021

A controlled trial of artemether or quinine in Vietnamese adults with severe falciparum malaria

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970247-7

7 January 2021

Severe and complicated falciparum malaria in Melanesian adults in Papua New Guinea

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970247-7

7 January 2021

Acute renal failure in patients with severe falciparum malaria.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970247-7

7 January 2021

The clinical spectrum of severe imported falciparum malaria in the intensive care unit: report of 188 cases in adults

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970247-7

7 January 2021

Severe and complicated malaria treated with artemisinin, artesunate or artemether in Viet Nam.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970247-7

7 January 2021

Short report: hepatitis b infection and severe Plasmodium falciparum malaria in Vietnamese adults

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970247-7

7 January 2021

Limited level of accuracy provided by available rapid diagnosis tests for malaria enhances the need for PCR-based reference laboratories

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970247-7

7 January 2021

Genotyping of Plasmodium falciparum infections by PCR: a comparative multicentre study

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970247-7

7 January 2021

Differentiating the pathologies of cerebral malaria by postmortem parasite counts

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970247-7

7 January 2021

Lumbar puncture in cerebral malaria

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970247-7

7 January 2021

Increased cerebrospinal fluid protein and lipid peroxidation products in patients with cerebral malaria

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970247-7

7 January 2021

Magnetic resonance imaging of the brain in patients with cerebral malaria

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970247-7

7 January 2021

Cytoadherence, pathogenesis and the infected red cell surface in Plasmodium falciparum.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970247-7

7 January 2021

Platelet-mediated clumping of Plasmodium falciparum-infected erythrocytes is a common adhesive phenotype and is associated with severe malaria

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970247-7

7 January 2021

Reduced microcirculatory flow in severe falciparum malaria: pathophysiology and electron-microscopic pathology

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970247-7

7 January 2021

The role of cerebral oedema in the pathogenesis of cerebral malaria

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970247-7

7 January 2021

Perturbations of cerebral hemodynamics in Kenyans with cerebral malaria

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970247-7

7 January 2021

Randomized trial of volume expansion with albumin or saline in children with severe malaria: preliminary evidence of albumin benefit

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970247-7

7 January 2021

Blood-brain barrier function in cerebral malaria in Malawian children.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970247-7

7 January 2021

Blood-brain barrier function in cerebral malaria and CNS infections in Vietnam

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970247-7

7 January 2021

Prognostic risk factors and post mortem findings in cerebral malaria in children

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970247-7

7 January 2021

Possible central role of nitric oxide in conditions clinically similar to cerebral malaria.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970247-7

7 January 2021

Are reactive oxygen species involved in the pathogenesis of murine cerebral malaria?

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970247-7

7 January 2021

Oxidative stress and erythrocyte damage in Kenyan children with severe Plasmodium falciparum malaria.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970247-7

7 January 2021

Cerebrospinal fluid studies in children with cerebral malaria: an excitotoxic mechanism?

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970247-7

7 January 2021

The clinical significance of cerebrospinal fluid levels of kynurenine pathway metabolites and lactate in severe malaria

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970247-7

7 January 2021

Metabolites of the kynurenine pathway of tryptophan metabolism in the cerebrospinal fluid of Malawian children with malaria

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970247-7

7 January 2021

Inhibitory immunoglobulin M antibodies to tumor necrosis factor-inducing toxins in patients with malaria

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970247-7

7 January 2021

A primate model for human cerebral malaria: Plasmodium coatneyi-infected rhesus monkeys.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970247-7

7 January 2021

Effects of endotoxin and dexamethasone on cerebral malaria in mice.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970247-7

7 January 2021

Rapid switching to multiple antigenic and adhesive phenotypes in malaria

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970247-7

7 January 2021

Plasmodium falciparum-infected erythrocytes: agglutination by diverse Kenyan plasma is associated with severe disease and young host age.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970247-7

7 January 2021

Commonly recognised Plasmodium falciparum parasites cause cerebral malaria

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970247-7

7 January 2021

Molecules on the surface of the Plasmodium falciparum infected erythrocyte and their role in malaria pathogenesis and immune evasion

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970247-7

7 January 2021

Receptor-specific adhesion and clinical disease in Plasmodium falciparum

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970247-7

7 January 2021

Intercellular adhesion molecule-1 is an endothelial cell adhesion receptor for Plasmodium falciparum.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970247-7

7 January 2021

A quantitative analysis of the microvascular sequestration of malaria parasites in the human brain

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970247-7

7 January 2021

A functional analysis of a natural variant of intercellular adhesion molecule-1 (ICAM-1Kilifi).

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970247-7

7 January 2021

A high frequency African coding polymorphism in the N-terminal domain of ICAM-1 predisposing to cerebral malaria in Kenya.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970247-7

7 January 2021

Absence of an association between intercellular adhesion molecule 1, complement receptor 1 and interleukin 1 receptor antagonist gene polymorphisms and severe malaria in a West African population

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970247-7

7 January 2021

Prognostic significance of reduced red blood cell deformability in severe falciparum malaria.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970247-7

7 January 2021

The role of reduced red cell deformability in the pathogenesis of severe falciparum malaria and its restoration by blood transfusion

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970247-7

7 January 2021

Serum levels of the proinflammatory cytokines interleukin-1 beta (IL-1beta), IL-6, IL-8, IL-10, tumor necrosis factor alpha, and IL-12(p70) in Malian children with severe Plasmodium falciparum malaria and matched uncomplicated malaria or healthy con

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970247-7

7 January 2021

Tumour necrosis factor, fever and fatality in falciparum malaria

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970247-7

7 January 2021

Tumor necrosis factor ? in the pathogenesis of cerebral malaria

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970247-7

7 January 2021

Variation in the TNF-alpha promoter region associated with susceptibility to cerebral malaria.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970247-7

7 January 2021

The prognostic and pathophysiologic role of pro- and antiinflammatory cytokines in severe malaria

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970247-7

7 January 2021

Cytokine expression in the brain in human cerebral malaria

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970247-7

7 January 2021

Tissue distribution of migration inhibitory factor and inducible nitric oxide synthase in falciparum malaria and sepsis in African children

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970247-7

7 January 2021

Nitric oxide in Tanzanian children with malaria: inverse relationship between malaria severity and nitric oxide production/nitric oxide synthase type 2 expression

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970247-7

7 January 2021

Age-dependent effect of plasma nitric oxide on parasite density in Ghanaian children with severe malaria

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970247-7

7 January 2021

Pathogenesis of malaria and clinically similar conditions

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970247-7

7 January 2021

Review Article: blood-brain barrier in falciparum malaria.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970247-7

7 January 2021

Evidence of blood-brain barrier dysfunction in human cerebral malaria

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970247-7

7 January 2021

Breaking down the blood–brain barrier: signaling a path to cerebral malaria?

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970247-7

7 January 2021

Adult cerebral malaria: prognostic importance of imaging findings and correlation with postmortem findings

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970247-7

7 January 2021

Do patients with cerebral malaria have cerebral oedema? A computed tomography study

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970247-7

7 January 2021

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970247-7

1 reference

7 January 2021

Axonal injury in cerebral malaria

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970247-7

7 January 2021

Cerebrospinal fluid levels of markers of brain parenchymal damage in Vietnamese adults with severe malaria.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970247-7

7 January 2021

Predictors of a fatal outcome following childhood cerebral malaria.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970247-7

7 January 2021

Hemofiltration and peritoneal dialysis in infection-associated acute renal failure in Vietnam

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970247-7

7 January 2021

Persistent neurocognitive impairments associated with severe falciparum malaria in Kenyan children.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970247-7

7 January 2021

Increased prevalence of epilepsy associated with severe falciparum malaria in children.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970247-7

7 January 2021

Absence of neuropsychological sequelae following cerebral malaria in Gambian children.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970247-7

7 January 2021

Effects of early cerebral malaria on cognitive ability in Senegalese children

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970247-7

7 January 2021

Developmental impairments following severe falciparum malaria in children

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970247-7

7 January 2021

Post-malaria neurological syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970247-7

7 January 2021

Psychological testing of cerebral malaria patients.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970247-7

7 January 2021

Neuropsychiatric sequelae of cerebral malaria in Vietnam veterans

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970247-7

7 January 2021

Delayed neuropsychiatric effects of malaria in Ghana.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970247-7

7 January 2021

Management of severe malaria in children: proposed guidelines for the United Kingdom

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970247-7

7 January 2021

Towards optimal regimens of parenteral quinine for young African children with cerebral malaria: unbound quinine concentrations following a simple loading dose regimen.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970247-7

7 January 2021

Rectal artemether versus intravenous quinine for the treatment of cerebral malaria in children in Uganda: randomised clinical trial

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970247-7

7 January 2021

The pharmacokinetic properties of intramuscular quinine in Gambian children with severe falciparum malaria.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970247-7

7 January 2021

Exchange transfusion as an adjunct therapy in severe Plasmodium falciparum malaria: a meta-analysis.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970247-7

7 January 2021

Loading dose of quinine in African children with cerebral malaria.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970247-7

7 January 2021

Diagnosis and Treatment of Malaria in Children

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970247-7

7 January 2021

An open randomized clinical study of intrarectal versus infused Quinimax for the treatment of childhood cerebral malaria in Niger

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970247-7

7 January 2021

Quinine and severe falciparum malaria in late pregnancy.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970247-7

7 January 2021

A meta-analysis using individual patient data of trials comparing artemether with quinine in the treatment of severe falciparum malaria

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970247-7

7 January 2021

Artesunate versus quinine for treatment of severe falciparum malaria: a randomised trial

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970247-7

7 January 2021

Artesunate combinations for treatment of malaria: meta-analysis

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970247-7

7 January 2021

Arteether-induced brain injury in Macaca mulatta. I. The precerebellar nuclei: the lateral reticular nuclei, paramedian reticular nuclei, and perihypoglossal nuclei.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970247-7

7 January 2021

Neuropathological assessment of artemether-treated severe malaria

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970247-7

7 January 2021

Pentoxifylline as a supportive agent in the treatment of cerebral malaria in children.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970247-7

7 January 2021

Prophylactic phenobarbitone in young children with severe falciparum malaria: pharmacokinetics and clinical effects

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970247-7

7 January 2021

Effect of phenobarbital on seizure frequency and mortality in childhood cerebral malaria: a randomised, controlled intervention study

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970247-7

7 January 2021

Single dose phenobarbitone prevents convulsions in cerebral malaria

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970247-7

7 January 2021

Population kinetics, efficacy, and safety of dichloroacetate for lactic acidosis due to severe malaria in children

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2805%2970247-7

7 January 2021

10.1016/S1474-4422(05)70247-7

Identifiers

DOI

1 reference

13 August 2017

1 reference

PubMed ID

16297841