Exploring the tumour environment: cancer-associated fibroblasts as targets in cancer therapy (Q36318551)

13 August 2017

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title

Exploring the tumour environment: cancer-associated fibroblasts as targets in cancer therapy (English)

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cancer-associated fibroblast

13 August 2017

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Patrick Micke

1

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PubMed ID

16300472

13 August 2017

Arne Ostman

series ordinal

2

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PubMed ID

16300472

13 August 2017

language of work or name

English

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publication date

1 December 2005

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Expert Opinion on Therapeutic Targets

13 August 2017

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13 August 2017

9

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13 August 2017

6

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13 August 2017

1217-1233

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Cancer genes and the pathways they control

13 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1217

21 January 2018

The Hallmarks of Cancer

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1217

Glivec (STI571, imatinib), a rationally developed, targeted anticancer drug

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1217

Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1217

Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1217

Effect of the tyrosine kinase inhibitor STI571 in a patient with a metastatic gastrointestinal stromal tumor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1217

Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1217

Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1217

Stromal fibroblasts in cancer initiation and progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1217

Putting tumours in context

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1217

Friends or foes - bipolar effects of the tumour stroma in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1217

The not-so innocent bystander: the microenvironment as a therapeutic target in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1217

21 January 2018

Cancer without disease.

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1217

Tumor angiogenesis: therapeutic implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1217

Cancer immunotherapy: moving beyond current vaccines

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1217

Wounding and its role in RSV-mediated tumor formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1217

Helicobacter pylori and gastrointestinal tract adenocarcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1217

Tumors and inflammatory infiltrates: friends or foes?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1217

Integrative radiation carcinogenesis: interactions between cell and tissue responses to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1217

Radiation to stromal fibroblasts increases invasiveness of pancreatic cancer cells through tumor-stromal interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1217

Distinct epigenetic changes in the stromal cells of breast cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1217

A juvenile polyposis tumor suppressor locus at 10q22 is deleted from nonepithelial cells in the lamina propria.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1217

Evidence for nonautonomous effect of p53 tumor suppressor in carcinogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1217

TGF-beta stimulation and inhibition of cell proliferation: new mechanistic insights

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1217

Regulation of PDGF and its receptors in fibrotic diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1217

Regulation of cell growth and the expression of extracellular matrix proteins in colorectal adenocarcinoma: a fibroblast-tumor cell coculture model to study tumor-host interactions in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1217

NK4, a four-kringle antagonist of HGF, inhibits spreading and invasion of human pancreatic cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1217

Gene expression profiling of tumor-stromal interactions between pancreatic cancer cells and stromal fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1217

A heterologous 3-D coculture model of breast tumor cells and fibroblasts to study tumor-associated fibroblast differentiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1217

Fibroblast-mediated acceleration of human epithelial tumor growth in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1217

A system for studying epithelial-stromal interactions reveals distinct inductive abilities of stromal cells from benign prostatic hyperplasia and prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1217

Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1217

The stromal proteinase MMP3/stromelysin-1 promotes mammary carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1217

Platelet-derived growth factor (PDGF) in oncogenesis: development of a vascular connective tissue stroma in xenotransplanted human melanoma producing PDGF-BB

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1217

Suppression of tumor development and metastasis formation in mice lacking the S100A4(mts1) gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1217

TGF-beta signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1217

Loss of TGF-beta type II receptor in fibroblasts promotes mammary carcinoma growth and invasion through upregulation of TGF-alpha-, MSP- and HGF-mediated signaling networks

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1217

Platelet-derived growth factor production by B16 melanoma cells leads to increased pericyte abundance in tumors and an associated increase in tumor growth rate

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1217

Endothelial and nonendothelial sources of PDGF-B regulate pericyte recruitment and influence vascular pattern formation in tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1217

Tumorigenic conversion of immortal human keratinocytes through stromal cell activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1217

Human breast carcinoma desmoplasia is PDGF initiated.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1217

The IGF‐1 receptor in cancer biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1217

Tumor Rejection by Modulation of Tumor Stromal Fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1217

Immunosuppressive networks in the tumour environment and their therapeutic relevance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1217

Overexpression and regulation of expression of scatter factor/hepatocyte growth factor in prostatic carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1217

Expression of immunoreactive human hepatocyte growth factor in human esophageal squamous cell carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1217

The tumour-stromal interaction between intratumoral c-Met and stromal hepatocyte growth factor associated with tumour growth and prognosis in non-small-cell lung cancer patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1217

Met, metastasis, motility and more

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1217

Reconstruction of functionally normal and malignant human breast tissues in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1217

c-Met: structure, functions and potential for therapeutic inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1217

Targeting the tumor and its microenvironment by a dual-function decoy Met receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1217

Peripheral lymph node stromal cells can promote growth and tumorigenicity of breast carcinoma cells through the release of IGF-I and EGF.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1217

New insights into the role of extracellular matrix during tumor onset and progression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1217

Breast cancer cells induce stromal fibroblasts to express MMP-9 via secretion of TNF-alpha and TGF-beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1217

In vivo evidence that the stromelysin-3 metalloproteinase contributes in a paracrine manner to epithelial cell malignancy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1217

Inhibition of stromal matrix metalloproteases: effects on breast-tumor promotion by fibroblasts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1217

Expression of proteolytic enzymes in head and neck cancer-associated fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1217

Reduced metastasis of transgenic mammary cancer in urokinase-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1217

Reduced metastasis of Polyoma virus middle T antigen-induced mammary cancer in plasminogen-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1217

Cysteine cathepsins (proteases)--on the main stage of cancer?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1217

Cathepsin cysteine proteases are effectors of invasive growth and angiogenesis during multistage tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1217

Stromal expression of vascular endothelial growth factor correlates with tumor grade and microvessel density in mammary phyllodes tumors: a multicenter study of 185 cases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1217

Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1217

Molecular classification of cancer: class discovery and class prediction by gene expression monitoring

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1217

Gene expression profiling to identify oncogenic determinants of autocrine human growth hormone in human mammary carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1217

DNA-microarray analysis of brain cancer: molecular classification for therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1217

Diagnostic classification of cancer using DNA microarrays and artificial intelligence

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1217

Trends in microarray analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1217

Role of cancer-associated stromal fibroblasts in metastatic colon cancer to the liver and their expression profiles

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1217

The development of a functionally relevant cell culture model of progressive human breast cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1217

Molecular characterization of the tumor microenvironment in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1217

Characterization of gene expression in mucinous cystic neoplasms of the pancreas using oligonucleotide microarrays

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1217

Diversity, topographic differentiation, and positional memory in human fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1217

Development of TGF-beta signalling inhibitors for cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1217

c-Met as a target for human cancer and characterization of inhibitors for therapeutic intervention

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1217

A randomized phase II feasibility trial of BMS-275291 in patients with early stage breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1217

Stromal antigen targeting by a humanised monoclonal antibody: an early phase II trial of sibrotuzumab in patients with metastatic colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1217

Frequent somatic mutations in PTEN and TP53 are mutually exclusive in the stroma of breast carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.6.1217

10.1517/14728222.9.6.1217

21 January 2018

Identifiers

DOI

1 reference

13 August 2017

1 reference

PubMed ID

16300472