Bone morphogenetic protein receptor type 1A (Q3631924)

TGFβ superfamily receptor

1 reference

activin types I and II receptor domain, protein family

1 reference

Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family

1 reference

GS domain, protein family

1 reference

Protein kinase domain, protein family

1 reference

Protein kinase, ATP binding site, protein family

1 reference

Serine/threonine-protein kinase, active site, protein family

1 reference

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36894

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

8 April 2019

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36894

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36894

protein kinase activity

1 reference

8 April 2019

protein homodimerization activity

1 reference

8 April 2019

BMP-2/4 and BMP-6/7 differentially utilize cell surface receptors to induce osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36894

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36894

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36894

15 references

8 April 2019

A GDF5 point mutation strikes twice--causing BDA1 and SYNS2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36894

8 April 2019

New insights into the molecular mechanism of multiple synostoses syndrome (SYNS): mutation within the GDF5 knuckle epitope causes noggin-resistance

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36894

8 April 2019

Transforming growth factor-beta receptor-associated protein 1 is a Smad4 chaperone

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36894

8 April 2019

Structure of the ternary signaling complex of a TGF-beta superfamily member

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36894

8 April 2019

Crystal structure of the BMP-2-BRIA ectodomain complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36894

8 April 2019

Repulsive guidance molecule is a structural bridge between neogenin and bone morphogenetic protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36894

8 April 2019

DIP2 disco-interacting protein 2 homolog A (Drosophila) is a candidate receptor for follistatin-related protein/follistatin-like 1--analysis of their binding with TGF-β superfamily proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36894

8 April 2019

WFIKKN1 and WFIKKN2 bind growth factors TGFβ1, BMP2 and BMP4 but do not inhibit their signalling activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36894

8 April 2019

The pro-form of BMP-2 interferes with BMP-2 signalling by competing with BMP-2 for IA receptor binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36894

8 April 2019

Molecular recognition of BMP-2 and BMP receptor IA

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36894

8 April 2019

Activating and deactivating mutations in the receptor interaction site of GDF5 cause symphalangism or brachydactyly type A2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36894

8 April 2019

Crystal structure analysis reveals a spring-loaded latch as molecular mechanism for GDF-5-type I receptor specificity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36894

8 April 2019

Bone morphogenetic proteins signal through the transforming growth factor-beta type III receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36894

8 April 2019

HFE interacts with the BMP type I receptor ALK3 to regulate hepcidin expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36894

8 April 2019

BMP-2/4 and BMP-6/7 differentially utilize cell surface receptors to induce osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36894

DNA-binding transcription factor activity, RNA polymerase II-specific

IPI

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36894

1 reference

24 April 2018

SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?protein=P36894&geneProductId=UniProtKB:P36894

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36894

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36894

8 April 2019

SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36894

transforming growth factor beta-activated receptor activity

IDA

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36894

transforming growth factor beta receptor activity, type I

IBA

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36894

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

IBA

growth factor binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36894

HFE-transferrin receptor complex

1 reference

8 April 2019

HFE interacts with the BMP type I receptor ALK3 to regulate hepcidin expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36894

2 references

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36894

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36894

1 reference

8 April 2019

Dynamics and interaction of caveolin-1 isoforms with BMP-receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36894

external side of plasma membrane

1 reference

8 April 2019

HFE interacts with the BMP type I receptor ALK3 to regulate hepcidin expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36894

integral component of plasma membrane

IDA

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36894

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36894

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36894

pattern specification process

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P36894&geneProductId=UniProtKB:P36894

roof of mouth development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36894

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36894

pituitary gland development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36894

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36894

chondrocyte differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36894

neural crest cell development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36894

lateral mesoderm development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36894

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36894

positive regulation of bone mineralization

1 reference

8 April 2019

BMP-2/4 and BMP-6/7 differentially utilize cell surface receptors to induce osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36894

embryonic organ development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36894

paraxial mesoderm structural organization

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36894

positive regulation of epithelial cell proliferation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36894

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36894

negative regulation of neurogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36894

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36894

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36894

embryonic digit morphogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36894

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36894

cellular response to BMP stimulus

1 reference

8 April 2019

Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36894

in utero embryonic development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36894

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36894

BMP signaling pathway

5 references

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36894

8 April 2019

BMP-2/4 and BMP-6/7 differentially utilize cell surface receptors to induce osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36894

8 April 2019

Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36894

8 April 2019

HFE interacts with the BMP type I receptor ALK3 to regulate hepcidin expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36894

IC

hindlimb morphogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36894

nervous system development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36894

dorsal/ventral axis specification

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36894

regulation of lateral mesodermal cell fate specification

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36894

stem cell population maintenance

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36894

odontogenesis of dentin-containing tooth

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36894

Mullerian duct regression

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36894

positive regulation of transcription, DNA-templated

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36894

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36894

cartilage development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36894

positive regulation of osteoblast differentiation

1 reference

8 April 2019

BMP-2/4 and BMP-6/7 differentially utilize cell surface receptors to induce osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36894

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36894

transmembrane receptor protein serine/threonine kinase signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36894

positive regulation of mesenchymal cell proliferation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36894

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36894

neural plate pattern specification

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36894

embryonic morphogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36894

mesendoderm development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36894

1 reference

8 April 2019

Association of polymorphisms of IGF1R and genes in the transforming growth factor- beta /bone morphogenetic protein pathway with bacteremia in sickle cell anemia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36894

regulation of cellular senescence

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36894

neural plate mediolateral regionalization

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36894

dorsal/ventral pattern formation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36894

transforming growth factor beta receptor signaling pathway

1 reference

24 April 2018

Activin receptor-like kinases: a novel subclass of cell-surface receptors with predicted serine/threonine kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P36894&geneProductId=UniProtKB:P36894

positive regulation of SMAD protein signal transduction

TAS

1 reference

8 April 2019

Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36894

anterior/posterior pattern specification

IDA

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36894

paraxial mesoderm development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36894

positive regulation of pri-miRNA transcription by RNA polymerase II

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36894

negative regulation of smooth muscle cell migration

1 reference

8 April 2019

SM22alpha-targeted deletion of bone morphogenetic protein receptor 1A in mice impairs cardiac and vascular development, and influences organogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36894

BMP signaling pathway involved in heart development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36894

regulation of cardiac muscle cell apoptotic process

IC

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36894

positive regulation of transcription by RNA polymerase II

ISS

3 references

8 April 2019

SM22alpha-targeted deletion of bone morphogenetic protein receptor 1A in mice impairs cardiac and vascular development, and influences organogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36894

8 April 2019

Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36894

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36894

regulation of neural crest cell differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36894

ISS

Gene Atlas image

PBB GE BMPR1A 213578 at fs.png
732 × 530; 11 KB

0 references

has part(s)

protein kinase domain

1 reference

activin types I and II receptor domain

1 reference

protein kinase, ATP binding site

1 reference

GS domain

1 reference

serine/threonine-protein kinase, active site

1 reference

serine-threonine/tyrosine-protein kinase, catalytic domain

1 reference

Identifiers

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016