Evolvable signaling networks of receptor tyrosine kinases: relevance of robustness to malignancy and to cancer therapy (Q36327195)

13 August 2017

1 reference

8 February 2021

Evolvable signaling networks of receptor tyrosine kinases: relevance of robustness to malignancy and to cancer therapy (English)

1 reference

13 August 2017

receptor tyrosine kinase

1 reference

28 September 2019

1 reference

26 August 2020

1 reference

30 October 2020

1 reference

8 February 2021

1

Ido Amit

1 reference

13 August 2017

Ron Wides

2

1 reference

PMCID

2174628

13 August 2017

Yosef Yarden

series ordinal

3

1 reference

PMCID

2174628

13 August 2017

language of work or name

1 reference

4 December 2007

9 references

Molecular Systems Biology

13 August 2017

3 April 2019

20 June 2019

31 July 2019

28 September 2019

15 December 2019

26 August 2020

30 October 2020

8 February 2021

9 references

13 August 2017

3 April 2019

20 June 2019

31 July 2019

28 September 2019

15 December 2019

26 August 2020

30 October 2020

8 February 2021

3

1 reference

13 August 2017

151

1 reference

Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported

13 August 2017

8 references

3 April 2019

20 June 2019

31 July 2019

28 September 2019

15 December 2019

26 August 2020

30 October 2020

on focus list of Wikimedia project

8 February 2021

copyright status

copyrighted

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ScienceSource

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cites work

Cancer therapeutic antibodies come of age: targeting minimal residual disease

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Growth factor-induced MAPK network topology shapes Erk response determining PC-12 cell fate

30 September 2017

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HER2 therapy: molecular mechanisms of trastuzumab resistance.

30 September 2017

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30 September 2017

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30 September 2017

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HER2 kinase domain mutation results in constitutive phosphorylation and activation of HER2 and EGFR and resistance to EGFR tyrosine kinase inhibitors

30 September 2017

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An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor

30 September 2017

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A comprehensive pathway map of epidermal growth factor receptor signaling

30 September 2017

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Phosphotyrosine interactome of the ErbB-receptor kinase family

30 September 2017

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A model of acquired autoresistance to a potent ErbB2 tyrosine kinase inhibitor and a therapeutic strategy to prevent its onset in breast cancer

30 September 2017

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Mig6 is a negative regulator of EGF receptor-mediated skin morphogenesis and tumor formation

30 September 2017

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The dictyostelium kinome--analysis of the protein kinases from a simple model organism.

30 September 2017

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Cell-signalling dynamics in time and space

30 September 2017

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Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck

30 September 2017

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Cancer: a Systems Biology disease

30 September 2017

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BuCy RAFs drive cells into MEK addiction

30 September 2017

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Gene expression in human thyrocytes and autonomous adenomas reveals suppression of negative feedbacks in tumorigenesis

30 September 2017

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VEGF as a therapeutic target in cancer

30 September 2017

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A quantitative protein interaction network for the ErbB receptors using protein microarrays

30 September 2017

1 reference

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Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules

30 September 2017

1 reference

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ERBB receptors and cancer: the complexity of targeted inhibitors

30 September 2017

1 reference

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Involvement of microRNA in AU-rich element-mediated mRNA instability

30 September 2017

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When kinases meet mathematics: the systems biology of MAPK signalling

30 September 2017

1 reference

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Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain

30 September 2017

1 reference

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Decreased accessibility and lack of activation of ErbB2 in JIMT-1, a herceptin-resistant, MUC4-expressing breast cancer cell line.

30 September 2017

1 reference

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30 September 2017

Biological robustness

1 reference

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Robustness of cellular functions

30 September 2017

1 reference

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Bow ties, metabolism and disease

30 September 2017

1 reference

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PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients.

30 September 2017

1 reference

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Cancer genes and the pathways they control

30 September 2017

1 reference

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De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling

30 September 2017

1 reference

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Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib

30 September 2017

1 reference

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Promotion and attenuation of FGF signaling through the Ras-MAPK pathway

30 September 2017

1 reference

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Network motifs in integrated cellular networks of transcription-regulation and protein-protein interaction

30 September 2017

1 reference

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Under cover: causes, effects and implications of Hsp90-mediated genetic capacitance

30 September 2017

1 reference

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Role of protein ubiquitylation in regulating endocytosis of receptor tyrosine kinases

30 September 2017

1 reference

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High frequency of mutations of the PIK3CA gene in human cancers

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2174628

Network biology: understanding the cell's functional organization

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2174628

Multiple G-protein-coupled receptor signals converge on the epidermal growth factor receptor to promote migration and invasion

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2174628

A positive-feedback-based bistable 'memory module' that governs a cell fate decision

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2174628

Negative receptor signalling

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2174628

The evolution of signalling pathways in animal development

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2174628

Crystal structure of the complex of human epidermal growth factor and receptor extracellular domains

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2174628

Crystal structure of a truncated epidermal growth factor receptor extracellular domain bound to transforming growth factor alpha

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2174628

Cancer. Addiction to oncogenes--the Achilles heal of cancer

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2174628

Mutations of the BRAF gene in human cancer

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2174628

Divergence pattern of animal gene families and relationship with the Cambrian explosion

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2174628

Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2174628

Oncogenic kinase signalling

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2174628

Untangling the ErbB signalling network

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2174628

Feedback control of intercellular signalling in development

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2174628

The evolutionary fate and consequences of duplicate genes

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2174628

Highly Optimized Tolerance: Robustness and Design in Complex Systems

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2174628

Angiogenesis in cancer and other diseases

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2174628

Evolution of transcriptional regulation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2174628

Protein tyrosine kinase structure and function

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2174628

Protein kinases and phosphatases in the Drosophila genome

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2174628

Mathematical modeling of gene networks

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2174628

Inhibitory Fc receptors modulate in vivo cytotoxicity against tumor targets

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2174628

Control of EGF receptor signalling: lessons from fruitflies.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2174628

Signaling--2000 and beyond

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2174628

30 September 2017

The Hallmarks of Cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2174628

Emergence of Scaling in Random Networks

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2174628

The ErbB-2/HER2 oncoprotein of human carcinomas may function solely as a shared coreceptor for multiple stroma-derived growth factors

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2174628

Signaling specificity: the RTK/RAS/MAP kinase pathway in metazoans

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2174628

Id helix-loop-helix proteins inhibit nucleoprotein complex formation by the TCF ETS-domain transcription factors

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2174628

Feedback inhibition of macrophage tumor necrosis factor-alpha production by tristetraprolin

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2174628

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2174628

Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2174628

Insect cell-expressed p180erbB3 possesses an impaired tyrosine kinase activity

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2174628

Activation of RET as a dominant transforming gene by germline mutations of MEN2A and MEN2B

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2174628

The complex of polyoma virus middle-T antigen and pp60c-src

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2174628

Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2174628

Expression of a set of growth-related immediate early genes in BALB/c 3T3 cells: coordinate regulation with c-fos or c-myc

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2174628

ras oncogenes in human cancer: a review

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2174628

The let-23 gene necessary for Caenorhabditis elegans vulval induction encodes a tyrosine kinase of the EGF receptor subfamily

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2174628

Pathogenic poxviruses reveal viral strategies to exploit the ErbB signaling network

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2174628

Regulation of proto-oncogene fos: a paradigm for early response genes

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2174628

Genes for epidermal growth factor receptor, transforming growth factor alpha, and epidermal growth factor and their expression in human gliomas in vivo.

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2174628

Molecular evolution of the neurotrophin family members and their Trk receptors.

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2174628

A module of negative feedback regulators defines growth factor signaling

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2174628

Treating imatinib-resistant leukemia: the next generation targeted therapies.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2174628

TGFalpha expression impairs Trastuzumab-induced HER2 downregulation

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2174628

Phylogenetic analysis of Ciona intestinalis gene superfamilies supports the hypothesis of successive gene expansions.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2174628

Origins, lineage-specific expansions, and multiple losses of tyrosine kinases in eukaryotes

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2174628

Biological networks: the tinkerer as an engineer.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2174628

A genomewide survey of developmentally relevant genes in Ciona intestinalis. V. Genes for receptor tyrosine kinase pathway and Notch signaling pathway

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2174628

Birth of scale-free molecular networks and the number of distinct DNA and protein domains per genome.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2174628

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2174628

The multiple endocrine neoplasia type 2B point mutation switches the specificity of the Ret tyrosine kinase towards cellular substrates that are susceptible to interact with Crk and Nck

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2174628

Cancer as a robust system: implications for anticancer therapy

5 December 2018

1 reference

12 December 2020

Targeting tyrosine kinases in cancer: the second wave

1 reference

12 December 2020

Evolutionary analysis of the ErbB receptor and ligand families

1 reference

12 December 2020

Evolving protein interaction networks through gene duplication

1 reference

12 December 2020

Is genome size influenced by colonization of new environments in dipteran species?

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FMSB4100195

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1038/MSB4100195

1 reference

13 August 2017

1 reference

13 August 2017

1 reference

PMCID

2174628