Single-cell RNA-seq reveals changes in cell cycle and differentiation programs upon aging of hematopoietic stem cells (Q36333706)

13 August 2017

Single-cell RNA-seq reveals changes in cell cycle and differentiation programs upon aging of hematopoietic stem cells (English)

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single cell transcriptomics

13 August 2017

0 references

1 reference

A curated database reveals trends in single-cell transcriptomics

https://www.nxn.se/single-cell-studies/data.tsv

7 February 2021

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10

Aviv Regev

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13 August 2017

2

Itay Tirosh

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Monika Kowalczyk-Domagała

13 August 2017

1

object named as

Monika S Kowalczyk

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13 August 2017

Dirk Heckl

3

1 reference

13 August 2017

Tata Nageswara Rao

4

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13 August 2017

Atray Dixit

5

1 reference

13 August 2017

Brian J Haas

6

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13 August 2017

Rebekka K Schneider

7

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13 August 2017

Amy J Wagers

8

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13 August 2017

Benjamin L Ebert

9

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13 August 2017

1 October 2015

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external data available at URL

13 August 2017

https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE59114

1 reference

A curated database reveals trends in single-cell transcriptomics

https://www.nxn.se/single-cell-studies/data.tsv

7 February 2021

1 reference

13 August 2017

25

1 reference

13 August 2017

1860-1872

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13 August 2017

12

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describes a project that uses

13 August 2017

bone marrow

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A curated database reveals trends in single-cell transcriptomics

7 February 2021

https://www.nxn.se/single-cell-studies/data.tsv

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30 September 2017

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In Vivo RNAi screening identifies a leukemia-specific dependence on integrin beta 3 signaling

30 September 2017

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Single-cell transcriptomics reveals bimodality in expression and splicing in immune cells

30 September 2017

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Full-length mRNA-Seq from single-cell levels of RNA and individual circulating tumor cells

30 September 2017

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Gap 1 phase length and mouse embryonic stem cell self-renewal

30 September 2017

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Cdc42 activity regulates hematopoietic stem cell aging and rejuvenation

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Clonal analysis reveals multiple functional defects of aged murine hematopoietic stem cells

30 September 2017

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Heterogeneity and hierarchy within the most primitive hematopoietic stem cell compartment.

30 September 2017

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Functionally distinct hematopoietic stem cells modulate hematopoietic lineage potential during aging by a mechanism of clonal expansion

30 September 2017

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Distinct hematopoietic stem cell subtypes are differentially regulated by TGF-beta1.

30 September 2017

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30 September 2017

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30 September 2017

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30 September 2017

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30 September 2017

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30 September 2017

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30 September 2017

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SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells

30 September 2017

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Cell intrinsic alterations underlie hematopoietic stem cell aging.

30 September 2017

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Effects of aging on the homing and engraftment of murine hematopoietic stem and progenitor cells

30 September 2017

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Developmental activation of the Rb-E2F pathway and establishment of cell cycle-regulated cyclin-dependent kinase activity during embryonic stem cell differentiation

30 September 2017

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Identification of Lin(-)Sca1(+)kit(+)CD34(+)Flt3- short-term hematopoietic stem cells capable of rapidly reconstituting and rescuing myeloablated transplant recipients.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4665007

G1 cell-cycle control and cancer

30 September 2017

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A phase space model of hemopoiesis and the concept of stem cell renewal

30 September 2017

1 reference

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The relationship of patient age to the pathobiology of the clonal myeloid diseases

30 September 2017

1 reference

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Prevalence and outcomes of anemia in geriatrics: a systematic review of the literature

30 September 2017

1 reference

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30 September 2017

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A STOCHASTIC MODEL OF STEM CELL PROLIFERATION, BASED ON THE GROWTH OF SPLEEN COLONY-FORMING CELLS.

30 September 2017

1 reference

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Role of Plk2 (Snk) in mouse development and cell proliferation

30 September 2017

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30 September 2017

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Identification of genes periodically expressed in the human cell cycle and their expression in tumors

30 September 2017

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The Pezcoller lecture: cancer cell cycles revisited

30 September 2017

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Behavior of hematopoietic stem cells in a large animal

30 September 2017

1 reference

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Fundamental properties of unperturbed haematopoiesis from stem cells in vivo.

30 September 2017

1 reference

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The dynamics and regulators of cell fate decisions are revealed by pseudotemporal ordering of single cells

30 September 2017

1 reference

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Nonstochastic reprogramming from a privileged somatic cell state

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4665007

SLAM family markers are conserved among hematopoietic stem cells from old and reconstituted mice and markedly increase their purity

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4665007

An inhibition of cyclin-dependent kinases that lengthens, but does not arrest, neuroepithelial cell cycle induces premature neurogenesis

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4665007

Age-associated characteristics of murine hematopoietic stem cells

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4665007

Lineage commitment and maturation in hematopoietic cells: the case for extrinsic regulation.

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4665007

Mouse strain-dependent changes in frequency and proliferation of hematopoietic stem cells during aging: correlation between lifespan and cycling activity.

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4665007

The aging of hematopoietic stem cells

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4665007

Determination of bone marrow stem cell differentiation by stromal hemopoietic inductive microenvironments (HIM).

29 June 2018

1 reference

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Platelet-biased stem cells reside at the apex of the haematopoietic stem-cell hierarchy.

29 June 2018

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Single-cell gene expression analysis reveals genetic associations masked in whole-tissue experiments

22 September 2018

1 reference

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A short G1 phase is an intrinsic determinant of naïve embryonic stem cell pluripotency.

22 September 2018

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FLT3 expression initiates in fully multipotent mouse hematopoietic progenitor cells.

22 September 2018

1 reference

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Prospective isolation and molecular characterization of hematopoietic stem cells with durable self-renewal potential.

22 September 2018

1 reference

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Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair

22 September 2018

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Competitive clonal hematopoiesis in mouse chimeras explained by a stochastic model of stem cell organization.

22 September 2018

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Deterministic regulation of hematopoietic stem cell self-renewal and differentiation.

22 September 2018

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Contrasting patterns of retinoblastoma protein expression in mouse embryonic stem cells and embryonic fibroblasts

22 September 2018

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12 December 2020

The cell cycle of the pseudostratified ventricular epithelium of the embryonic murine cerebral wall

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12 December 2020

Long-term lymphohematopoietic reconstitution by a single CD34-low/negative hematopoietic stem cell

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12 December 2020

Growth curves and survival characteristics of the animals used in the Biomarkers of Aging Program

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12 December 2020

Upregulation of Flt3 expression within the bone marrow Lin(-)Sca1(+)c-kit(+) stem cell compartment is accompanied by loss of self-renewal capacity

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12 December 2020

Identifiers

DOI

10.1101/GR.192237.115

1 reference

13 August 2017

1 reference

13 August 2017

1 reference