Physiological and pathophysiological aspects of ceramide (Q36341274)

13 August 2017

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title

Physiological and pathophysiological aspects of ceramide (English)

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13 August 2017

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1

Erich Gulbins

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13 August 2017

Pin Lan Li

2

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13 August 2017

1 January 2006

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American Journal of Physiology - Regulatory, Integrative and Comparative Physiology

13 August 2017

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13 August 2017

290

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13 August 2017

R11-26

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13 August 2017

1

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Cell surface ceramide generation precedes and controls FcgammaRII clustering and phosphorylation in rafts.

13 August 2017

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00416.2005

Vav2 is an activator of Cdc42, Rac1, and RhoA

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00416.2005

Epidermal growth factor receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00416.2005

The caveolae membrane system

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00416.2005

Selected lipids activate phagosome actin assembly and maturation resulting in killing of pathogenic mycobacteria

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00416.2005

Caspase-3 is a component of Fas death-inducing signaling complex in lipid rafts and its activity is required for complete caspase-8 activation during Fas-mediated cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00416.2005

Molecular characterization and localization of the NAD(P)H oxidase components gp91-phox and p22-phox in endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00416.2005

Rituximab antiproliferative effect in B-lymphoma cells is associated with acid-sphingomyelinase activation in raft microdomains

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00416.2005

Membrane lipid microdomains and the role of PKCtheta in T cell activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00416.2005

Sphingosine-1-phosphate and sphingosylphosphorylcholine constrict renal and mesenteric microvessels in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00416.2005

Current molecular models for NADPH oxidase regulation by Rac GTPase

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00416.2005

Initiation of signal transduction through the T cell receptor requires the multivalent engagement of peptide/MHC ligands [corrected]

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00416.2005

Impaired muscarinic endothelium-dependent relaxation and cyclic guanosine 5'-monophosphate formation in atherosclerotic human coronary artery and rabbit aorta

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00416.2005

CD28 signals through acidic sphingomyelinase

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPREGU.00416.2005

Ceramide directly activates protein kinase C zeta to regulate a stress-activated protein kinase signaling complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00416.2005

Functions of lipid rafts in biological membranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00416.2005

Activation of the endothelial nitric-oxide synthase by tumor necrosis factor-alpha. A novel feedback mechanism regulating cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00416.2005

Therapeutic strategies to reduce TNF-alpha mediated cardiac contractile depression following ischemia and reperfusion

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00416.2005

Surgical implications of vascular endothelial physiology

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPREGU.00416.2005

The active site of lysosomal sphingomyelinase: evidence for the involvement of hydrophobic and ionic groups.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00416.2005

Pseudomonas aeruginosa-induced apoptosis is defective in respiratory epithelial cells expressing mutant cystic fibrosis transmembrane conductance regulator.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00416.2005

De novo ceramide regulates the alternative splicing of caspase 9 and Bcl-x in A549 lung adenocarcinoma cells. Dependence on protein phosphatase-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00416.2005

UV-C Light Induces Raft-associated Acid Sphingomyelinase and JNK Activation and Translocation Independently on a Nuclear Signal

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00416.2005

TNFR1-induced sphingomyelinase activation modulates TCR signaling by impairing store-operated Ca2+ influx

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00416.2005

Apoptotic signaling through CD95 (Fas/Apo-1) activates an acidic sphingomyelinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00416.2005

Asymmetric addition of ceramides but not dihydroceramides promotes transbilayer (flip-flop) lipid motion in membranes.

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPREGU.00416.2005

Ceramide enables fas to cap and kill.

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPREGU.00416.2005

Ceramide generation by two distinct pathways in tumor necrosis factor alpha-induced cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00416.2005

Redistribution of CD95, DR4 and DR5 in rafts accounts for the synergistic toxicity of resveratrol and death receptor ligands in colon carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00416.2005

Plasma ceramide and lysophosphatidylcholine inversely correlate with mortality in sepsis patients

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPREGU.00416.2005

Phospholipid unsaturation and plasma membrane organization

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPREGU.00416.2005

Endothelial apoptosis induced by inhibition of integrins alphavbeta3 and alphavbeta5 involves ceramide metabolic pathways

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPREGU.00416.2005

Mechanisms of Staphylococcus aureus induced apoptosis of human endothelial cells

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPREGU.00416.2005

CD95 rapidly clusters in cells of diverse origins.

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPREGU.00416.2005

Atherosclerosis or lipoprotein-induced endothelial dysfunction. Potential mechanisms underlying reduction in EDRF/nitric oxide activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00416.2005

PKCzeta regulates TNF-alpha-induced activation of NADPH oxidase in endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00416.2005

Host acid sphingomyelinase regulates microvascular function not tumor immunity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00416.2005

Defective TNF-alpha-mediated hepatocellular apoptosis and liver damage in acidic sphingomyelinase knockout mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00416.2005

PAF-mediated pulmonary edema: a new role for acid sphingomyelinase and ceramide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00416.2005

Apoptosis in myocardial ischemia-reperfusion.

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPREGU.00416.2005

Ceramide-mediated clustering is required for CD95-DISC formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00416.2005

Acidic sphingomyelinase mediates entry of N. gonorrhoeae into nonphagocytic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00416.2005

CD95 Signaling via Ceramide-rich Membrane Rafts

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPREGU.00416.2005

Host defense against Pseudomonas aeruginosa requires ceramide-rich membrane rafts

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00416.2005

CD95/CD95 ligand interactions on epithelial cells in host defense to Pseudomonas aeruginosa

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPREGU.00416.2005

Molecular mechanisms of ceramide-mediated CD95 clustering

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPREGU.00416.2005

Co-capping of ras proteins with surface immunoglobulins in B lymphocytes

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPREGU.00416.2005

NAD(P)H oxidase: role in cardiovascular biology and disease

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPREGU.00416.2005

FAS-induced apoptosis is mediated via a ceramide-initiated RAS signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00416.2005

Direct stimulation of Vav guanine nucleotide exchange activity for Ras by phorbol esters and diglycerides

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00416.2005

Ceramide-induced inhibition of T lymphocyte voltage-gated potassium channel is mediated by tyrosine kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00416.2005

Ionizing radiation acts on cellular membranes to generate ceramide and initiate apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00416.2005

Plasmodium falciparum phospholipase C hydrolyzing sphingomyelin and lysocholinephospholipids is a possible target for malaria chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00416.2005

Acid sphingomyelinase is involved in CEACAM receptor-mediated phagocytosis of Neisseria gonorrhoeae

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00416.2005

LDLs impair vasomotor function of the coronary microcirculation: role of superoxide anions

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00416.2005

Cathepsin D targeted by acid sphingomyelinase-derived ceramide

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00416.2005

Induction of tissue factor production but not the upregulation of adhesion molecule expression by ceramide in human vascular endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00416.2005

Physiology and pathophysiology of sphingolipid metabolism and signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00416.2005

Calcium-independent activation of endothelial nitric oxide synthase by ceramide

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00416.2005

Sindbis virus entry into cells triggers apoptosis by activating sphingomyelinase, leading to the release of ceramide

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00416.2005

Role for ceramide in cell cycle arrest.

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPREGU.00416.2005

Ceramide: a novel cell signaling mechanism for vasodilation

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPREGU.00416.2005

Intracellular mechanisms of L-selectin induced capping

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00416.2005

Role of caspases (ICE/CED 3 proteases) in DNA damage and cell death in response to a mitochondrial inhibitor, antimycin A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00416.2005

Localization of cystic fibrosis transmembrane conductance regulator to lipid rafts of epithelial cells is required for Pseudomonas aeruginosa-induced cellular activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00416.2005

Involvement of sphingomyelinases in TNF signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00416.2005

Imaging immune cell interactions and functions: SMACs and the Immunological Synapse

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00416.2005

Cisplatin-induced CD95 redistribution into membrane lipid rafts of HT29 human colon cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00416.2005

Stimulation of erythrocyte ceramide formation by platelet-activating factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00416.2005

Stimulation of CD95 (Fas) blocks T lymphocyte calcium channels through sphingomyelinase and sphingolipids.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00416.2005

Interactions between the components of the human NADPH oxidase: intrigues in the phox family

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00416.2005

Sphingolipid mediators in cardiovascular cell biology and pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00416.2005

Acid sphingomyelinase-deficient macrophages have defective cholesterol trafficking and efflux

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00416.2005

Essential role of the NADPH oxidase subunit p47(phox) in endothelial cell superoxide production in response to phorbol ester and tumor necrosis factor-alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00416.2005

Differential NADPH- versus NADH-dependent superoxide production by phagocyte-type endothelial cell NADPH oxidase

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00416.2005

Regulation of G-protein alpha i2 subunit expression by oxidized low-density lipoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00416.2005

Role of acidic sphingomyelinase in Fas/CD95-mediated cell death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00416.2005

Function and regulation of the CD95 (APO-1/Fas) ligand in the immune system

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00416.2005

Cell autonomous apoptosis defects in acid sphingomyelinase knockout fibroblasts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00416.2005

Current perspective on the role of apoptosis in atherothrombotic disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00416.2005

Pathogens: raft hijackers

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00416.2005

Oocyte apoptosis is suppressed by disruption of the acid sphingomyelinase gene or by sphingosine-1-phosphate therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00416.2005

Participation of Rac GTPase activating proteins in the deactivation of the phagocytic NADPH oxidase

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00416.2005

Effects of tumor necrosis factor-alpha on basal and stimulated endothelium-dependent vasomotion in human resistance vessel

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00416.2005

Observation of Topical Catalysis by Sphingomyelinase Coupled To Microspheres

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00416.2005

Endothelial apoptosis as the primary lesion initiating intestinal radiation damage in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00416.2005

Natural ceramide reverses Fas resistance of acid sphingomyelinase(-/-) hepatocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00416.2005

Sphingosine 1-phosphate preserves fertility in irradiated female mice without propagating genomic damage in offspring

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00416.2005

Role of mutant CFTR in hypersusceptibility of cystic fibrosis patients to lung infections.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00416.2005

Activation of human acid sphingomyelinase through modification or deletion of C-terminal cysteine

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00416.2005

Acid sphingomyelinase-deficient human lymphoblasts and mice are defective in radiation-induced apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00416.2005

Reactive oxygen species limit neutrophil life span by activating death receptor signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00416.2005

Zn2+-stimulated sphingomyelinase is secreted by many cell types and is a product of the acid sphingomyelinase gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00416.2005

Compartmentalization of TNF receptor 1 signaling: internalized TNF receptosomes as death signaling vesicles

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00416.2005

Fas preassociation required for apoptosis signaling and dominant inhibition by pathogenic mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00416.2005

Cholesterol, lipid rafts, and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00416.2005

Functional rafts in cell membranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00416.2005

The fluid mosaic model of the structure of cell membranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00416.2005

Tyrosine phosphorylation-dependent suppression of a voltage-gated K+ channel in T lymphocytes upon Fas stimulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00416.2005

Apoptotic mechanisms in acute renal failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00416.2005

Tumor necrosis factor inhibits stimulated but not basal release of nitric oxide

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00416.2005

Involvement of de novo ceramide biosynthesis in tumor necrosis factor-alpha/cycloheximide-induced cerebral endothelial cell death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00416.2005

Thalidomide-induced antiangiogenic action is mediated by ceramide through depletion of VEGF receptors, and is antagonized by sphingosine-1-phosphate

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00416.2005

Phosphorylation of Raf by ceramide-activated protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00416.2005

Sphingosine 1-phosphate breakdown in platelets

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00416.2005

Homocysteine activates NADH/NADPH oxidase through ceramide-stimulated Rac GTPase activity in rat mesangial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00416.2005

Pivotal role for acidic sphingomyelinase in cerebral ischemia-induced ceramide and cytokine production, and neuronal apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00416.2005

Endostatin uncouples NO and Ca2+ response to bradykinin through enhanced O2*- production in the intact coronary endothelium

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00416.2005

Expression of the Leo1-like domain of replicative senescence down-regulated Leo1-like (RDL) protein promotes senescence of 2BS fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00416.2005

Production and metabolism of ceramide in normal and ischemic-reperfused myocardium of rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00416.2005

Role of ceramide in TNF-alpha-induced impairment of endothelium-dependent vasorelaxation in coronary arteries

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00416.2005

Ceramide reduces endothelium-dependent vasodilation by increasing superoxide production in small bovine coronary arteries

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00416.2005

Ceramide-induced activation of NADPH oxidase and endothelial dysfunction in small coronary arteries

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00416.2005

Involvement of the acid sphingomyelinase pathway in uva-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00416.2005

Kinase suppressor of Ras is ceramide-activated protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00416.2005

Effects of neutral sphingomyelinase on phenylephrine-induced vasoconstriction and Ca(2+) mobilization in rat aortic smooth muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00416.2005

Caveolin 1-mediated regulation of receptor tyrosine kinase-associated phosphatidylinositol 3-kinase activity by ceramide

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00416.2005

Apoptotic, non-apoptotic, and anti-apoptotic pathways of tumor necrosis factor signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00416.2005

Sphingosine Mediates the Immediate Negative Inotropic Effects of Tumor Necrosis Factor-α in the Adult Mammalian Cardiac Myocyte

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00416.2005

10.1152/AJPREGU.00416.2005

21 January 2018

Identifiers

DOI

1 reference

13 August 2017

1 reference

PubMed ID

16352856