Urea-based inhibitors of Trypanosoma brucei methionyl-tRNA synthetase: selectivity and in vivo characterization. (Q36344515)

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5 February 2020

title

Urea-based inhibitors of Trypanosoma brucei methionyl-tRNA synthetase: selectivity and in vivo characterization (English)

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4

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Frederick S Buckner

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Wim G J Hol

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author name string

Sayaka Shibata

1

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J Robert Gillespie

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Ranae M Ranade

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Jessica E Kim

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Joy U Laydbak

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Frank H Zucker

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Christophe L M J Verlinde

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Erkang Fan

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language of work or name

English

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publication date

11 July 2012

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Journal of Medicinal Chemistry

5 February 2020

published in

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volume

55

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page(s)

6342-6351

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issue

14

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Selective inhibitors of methionyl-tRNA synthetase have potent activity against Trypanosoma brucei Infection in Mice

5 February 2020

cites work

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Characterization of the human mitochondrial methionyl-tRNA synthetase

30 September 2017

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30 September 2017

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The Alamar Blue assay to determine drug sensitivity of African trypanosomes (T.b. rhodesiense and T.b. gambiense) in vitro

30 September 2017

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Definition of the heterocyclic pharmacophore of bacterial methionyl tRNA synthetase inhibitors: potent antibacterially active non-quinolone analogues.

30 September 2017

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29 June 2018

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Continuous cultivation of Trypanosoma brucei blood stream forms in a medium containing a low concentration of serum protein without feeder cell layers

29 June 2018

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Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity

29 June 2018

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Protein farnesyltransferase inhibitors exhibit potent antimalarial activity

22 September 2018

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22 September 2018

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Nanomolar inhibitors of Staphylococcus aureus methionyl tRNA synthetase with potent antibacterial activity against gram-positive pathogens.

22 September 2018

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Novel experimental parameters to quantify the modulation of absorptive and secretory transport of compounds by P-glycoprotein in cell culture models of intestinal epithelium

5 December 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/22720744

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12 December 2020

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Identifiers

DOI

10.1021/JM300303E

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5 February 2020

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5 February 2020

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