Animal disease models generated by genetic engineering of polyamine metabolism. (Q36346501)

13 August 2017

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title

Animal disease models generated by genetic engineering of polyamine metabolism (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6740286&resulttype=core&format=json

12 May 2020

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3

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12 May 2020

Eija Pirinen

6

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6740286&resulttype=core&format=json

12 May 2020

author name string

Juhani Jänne

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6740286&resulttype=core&format=json

12 May 2020

Leena Alhonen

2

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12 May 2020

Marko Pietilä

4

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12 May 2020

Anne Uimari

5

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6740286&resulttype=core&format=json

12 May 2020

Mervi T Hyvönen

7

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6740286&resulttype=core&format=json

12 May 2020

Aki Järvinen

8

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12 May 2020

publication date

1 October 2005

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Journal of Cellular and Molecular Medicine

13 August 2017

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6740286&resulttype=core&format=json

12 May 2020

volume

9

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12 May 2020

issue

4

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6740286&resulttype=core&format=json

12 May 2020

page(s)

865-882

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6740286&resulttype=core&format=json

Genetic approaches to the cellular functions of polyamines in mammals

12 May 2020

cites work

1 reference

https://api.crossref.org/works/10.1111%2FJ.1582-4934.2005.TB00385.X

Clinical efficacy, tolerability, and safety of SAM486A, a novel polyamine biosynthesis inhibitor, in patients with relapsed or refractory non-Hodgkin's lymphoma: results from a phase II multicenter study

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1582-4934.2005.TB00385.X

Amine synthesis in rapidly growing tissues: ornithine decarboxylase activity in regenerating rat liver, chick embryo, and various tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1582-4934.2005.TB00385.X

Oxidation of spermidine and spermine in rat liver: purification and properties of polyamine oxidase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1582-4934.2005.TB00385.X

Identification and characterization of a novel flavin-containing spermine oxidase of mammalian cell origin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1582-4934.2005.TB00385.X

Induction of a protein inhibitor to ornithine decarboxylase by the end products of its reaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1582-4934.2005.TB00385.X

Ornithine decarboxylase antizyme: a novel type of regulatory protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1582-4934.2005.TB00385.X

Autoregulatory frameshifting in decoding mammalian ornithine decarboxylase antizyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1582-4934.2005.TB00385.X

Identification of hypusine, an unusual amino acid, in a protein from human lymphocytes and of spermidine as its biosynthetic precursor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1582-4934.2005.TB00385.X

Is hypusine essential for eukaryotic cell proliferation?

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1582-4934.2005.TB00385.X

Metabolic stability of alpha-methylated polyamine derivatives and their use as substitutes for the natural polyamines

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1582-4934.2005.TB00385.X

A perspective of polyamine metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1582-4934.2005.TB00385.X

Abnormal ornithine decarboxylase activity in transgenic mice increases tumor formation and infertility.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1582-4934.2005.TB00385.X

Enhanced papilloma formation in response to skin tumor promotion in transgenic mice overexpressing the human ornithine decarboxylase gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1582-4934.2005.TB00385.X

Co-operation between follicular ornithine decarboxylase and v-Ha-ras induces spontaneous papillomas and malignant conversion in transgenic skin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1582-4934.2005.TB00385.X

A definitive role of ornithine decarboxylase in photocarcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1582-4934.2005.TB00385.X

Haploinsufficiency for odc modifies mouse skin tumor susceptibility

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1582-4934.2005.TB00385.X

Activation of polyamine catabolism profoundly alters tissue polyamine pools and affects hair growth and female fertility in transgenic mice overexpressing spermidine/spermine N1-acetyltransferase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1582-4934.2005.TB00385.X

Relation of skin polyamines to the hairless phenotype in transgenic mice overexpressing spermidine/spermine N-acetyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1582-4934.2005.TB00385.X

Targeted expression of spermidine/spermine N1-acetyltransferase increases susceptibility to chemically induced skin carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1582-4934.2005.TB00385.X

Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1582-4934.2005.TB00385.X

A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1582-4934.2005.TB00385.X

Potent modulation of intestinal tumorigenesis in Apcmin/+ mice by the polyamine catabolic enzyme spermidine/spermine N1-acetyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1582-4934.2005.TB00385.X

Activated polyamine catabolism depletes acetyl-CoA pools and suppresses prostate tumor growth in TRAMP mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1582-4934.2005.TB00385.X

The ornithine decarboxylase gene is a transcriptional target of c-Myc

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1582-4934.2005.TB00385.X

Targeting ornithine decarboxylase in Myc-induced lymphomagenesis prevents tumor formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1582-4934.2005.TB00385.X

Disturbed keratinocyte differentiation in transgenic mice and organotypic keratinocyte cultures as a result of spermidine/spermine N-acetyltransferase overexpression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1582-4934.2005.TB00385.X

Discovery of a spermatogenesis stage-specific ornithine decarboxylase antizyme: antizyme 3

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1582-4934.2005.TB00385.X

Altered levels of growth-related and novel gene transcripts in reproductive and other tissues of female mice overexpressing spermidine/spermine N1-acetyltransferase (SSAT).

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1582-4934.2005.TB00385.X

Transgenic animals as models in the study of the neurobiological role of polyamines

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1582-4934.2005.TB00385.X

Seizure activity-induced changes in polyamine metabolism and neuronal pathology during the postnatal period in rat brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1582-4934.2005.TB00385.X

Elevated seizure threshold and impaired spatial learning in transgenic mice with putrescine overproduction in the brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1582-4934.2005.TB00385.X

Transgenic rats as models for studying the role of ornithine decarboxylase expression in permanent middle cerebral artery occlusion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1582-4934.2005.TB00385.X

Neuroprotective role of ornithine decarboxylase activation in transient focal cerebral ischaemia: a study using ornithine decarboxylase-overexpressing transgenic rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1582-4934.2005.TB00385.X

Enhanced ornithine decarboxylase activity is associated with attenuated rate of damage evolution and reduction of infarct volume in transient middle cerebral artery occlusion in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1582-4934.2005.TB00385.X

Overexpression of spermidine/spermine N1-acetyltransferase elevates the threshold to pentylenetetrazol-induced seizure activity in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1582-4934.2005.TB00385.X

Spermidine/spermine N1-acetyltransferase overexpression in mice induces hypoactivity and spatial learning impairment

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1582-4934.2005.TB00385.X

Characterization of polyamines having agonist, antagonist, and inverse agonist effects at the polyamine recognition site of the NMDA receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1582-4934.2005.TB00385.X

Activation of polyamine catabolism in transgenic rats induces acute pancreatitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1582-4934.2005.TB00385.X

A polyamine analogue prevents acute pancreatitis and restores early liver regeneration in transgenic rats with activated polyamine catabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1582-4934.2005.TB00385.X

Acute pancreatitis induced by activation of the polyamine catabolism in gene-modified mice and rats overexpressing spermidine/spermine N1-acetyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1582-4934.2005.TB00385.X

Gossypol activates pancreatic polyamine catabolism in normal rats and induces acute pancreatitis in transgenic rats over-expressing spermidine/spermine N1-acetyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1582-4934.2005.TB00385.X

Alpha-hydrazino-ornithine blocks net synthesis of putrescine but not of RNA and DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1582-4934.2005.TB00385.X

Manipulation of metallothionein expression in the regenerating rat liver using antisense oligonucleotides.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1582-4934.2005.TB00385.X

Polyamines are required for the initiation of rat liver regeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1582-4934.2005.TB00385.X

The role of hypusine depletion in cytostasis induced by S-adenosyl-L-methionine decarboxylase inhibition: new evidence provided by 1-methylspermidine and 1,12-dimethylspermine

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1582-4934.2005.TB00385.X

Overexpression of antizyme in the hearts of transgenic mice prevents the isoprenaline-induced increase in cardiac ornithine decarboxylase activity and polyamines, but does not prevent cardiac hypertrophy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1582-4934.2005.TB00385.X

Role of polyamines in isoproterenol-induced cardiac hypertrophy: effects of alpha-difluoromethylornithine, an irreversible inhibitor of ornithine decarboxylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1582-4934.2005.TB00385.X

Comparative properties of arginases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1582-4934.2005.TB00385.X

Generation of a mouse model for arginase II deficiency by targeted disruption of the arginase II gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1582-4934.2005.TB00385.X

The ornithine decarboxylase gene is essential for cell survival during early murine development

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1582-4934.2005.TB00385.X

Essential role of S-adenosylmethionine decarboxylase in mouse embryonic development

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1582-4934.2005.TB00385.X

Cloning and sequencing of an intronless mouse S-adenosylmethionine decarboxylase gene coding for a functional enzyme strongly expressed in the liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1582-4934.2005.TB00385.X

Spermine deficiency in Gy mice caused by deletion of the spermine synthase gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1582-4934.2005.TB00385.X

The Gy mutation: another cause of X-linked hypophosphatemia in mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1582-4934.2005.TB00385.X

Spermine synthesis is required for normal viability, growth, and fertility in the mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1582-4934.2005.TB00385.X

Modulation of potassium channels in the hearts of transgenic and mutant mice with altered polyamine biosynthesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1582-4934.2005.TB00385.X

Characterization of transgenic mice with widespread overexpression of spermine synthase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1582-4934.2005.TB00385.X

Targeted disruption of spermidine/spermine N1-acetyltransferase gene in mouse embryonic stem cells. Effects on polyamine homeostasis and sensitivity to polyamine analogues

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1582-4934.2005.TB00385.X

Amino acid sequences common to rapidly degraded proteins: the PEST hypothesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1582-4934.2005.TB00385.X

Pronounced reduction in adenoma recurrence associated with aspirin use and a polymorphism in the ornithine decarboxylase gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1582-4934.2005.TB00385.X

X-linked spermine synthase gene (SMS) defect: the first polyamine deficiency syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1582-4934.2005.TB00385.X

Gene dosage of the spermidine/spermine N(1)-acetyltransferase ( SSAT) gene with putrescine accumulation in a patient with a Xp21.1p22.12 duplication and keratosis follicularis spinulosa decalvans (KFSD)

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1582-4934.2005.TB00385.X

Overexpression of spermidine/spermine N-acetyltransferase in transgenic mice protects the animals from kainate-induced toxicity

21 January 2018

1 reference

12 December 2020

Chemopreventive efficacy of combined piroxicam and difluoromethylornithine treatment of Apc mutant Min mouse adenomas, and selective toxicity against Apc mutant embryos

1 reference

12 December 2020

Spermine deficiency resulting from targeted disruption of the spermine synthase gene in embryonic stem cells leads to enhanced sensitivity to antiproliferative drugs

1 reference

12 December 2020

Inhibitory effects of orally administered green tea, black tea, and caffeine on skin carcinogenesis in mice previously treated with ultraviolet B light (high-risk mice): relationship to decreased tissue fat.

1 reference

12 December 2020

Cloning and characterization of a human polyamine oxidase that is inducible by polyamine analogue exposure

1 reference

12 December 2020

Targeted antizyme expression in the skin of transgenic mice reduces tumor promoter induction of ornithine decarboxylase and decreases sensitivity to chemical carcinogenesis.

1 reference

12 December 2020

Antizyme overexpression in transgenic mice reduces cell proliferation, increases apoptosis, and reduces N-nitrosomethylbenzylamine-induced forestomach carcinogenesis.

1 reference

12 December 2020

Polyamine metabolism and cancer.

1 reference

12 December 2020

The pharmacology of spermine and spermidine; distribution and excretion

1 reference

12 December 2020

Polyamine metabolism in different pathological states of the brain

1 reference

12 December 2020

A Phase II study of the polyamine analog N1,N11-diethylnorspermine (DENSpm) daily for five days every 21 days in patients with previously treated metastatic breast cancer.

1 reference

12 December 2020

Id2 is dispensable for myc-induced lymphomagenesis

1 reference

12 December 2020

Transgenic mice aberrantly expressing human ornithine decarboxylase gene

1 reference

12 December 2020

Characterization of a transgenic mouse line over-expressing the human ornithine decarboxylase gene

1 reference

12 December 2020

Inhibition of polyamine synthesis by alpha-difluoromethylornithine and its effects on pancreatic secretion and growth in the rat.

1 reference

12 December 2020

Effects of polyamines on the binding of [3H]MK-801 to the N-methyl-D-aspartate receptor: pharmacological evidence for the existence of a polyamine recognition site

1 reference

12 December 2020

Implication of ornithine decarboxylase and polyamines in pancreatic growth of neonatal rats

1 reference

12 December 2020

Stimulation of Spermidine Synthesis in the Regenerating Rat Liver: Relation to Increased Ornithine Decarboxylase Activity

1 reference

12 December 2020

Studies on the biosynthetic pathway of polyamines in rat liver

1 reference

12 December 2020

Effect of alpha-difluoromethylornithine on polyamine and DNA synthesis in regenerating rat liver: reversal of inhibition of DNA synthesis by putrescine

1 reference

12 December 2020

Life‐long over‐expression of ornithine decarboxylase (ODC) gene in transgenic mice does not lead to generally enhanced tumorigenesis or neuronal degeneration

1 reference

12 December 2020

Point mutation of ornithine decarboxylase gene in human hepatocellular carcinoma

1 reference

12 December 2020

Increased frequency of spontaneous skin tumors in transgenic mice which overexpress ornithine decarboxylase.

1 reference

12 December 2020

Induction and subcellular localization of metallothionein in regenerating rat liver

1 reference

12 December 2020

Polyamines and regulation of spermatogenesis: selective stimulation of late spermatogonia in transgenic mice overexpressing the human ornithine decarboxylase gene

1 reference

12 December 2020

Transgenic mice over-producing putrescine in their tissues do not convert the diamine into higher polyamines

1 reference

12 December 2020

Transformation of NIH/3T3 cells by ornithine decarboxylase overexpression.

1 reference

12 December 2020

Spermidine/spermine N1-acetyltransferase--the turning point in polyamine metabolism

1 reference

12 December 2020

Cerebral energy metabolism and immediate early gene induction following severe incomplete ischaemia in transgenic mice overexpressing the human ornithine decarboxylase gene: evidence that putrescine is not neurotoxic in vivo

1 reference

12 December 2020

Modulation of murine hair follicle function by alterations in ornithine decarboxylase activity

1 reference

12 December 2020

Sequence-dependent effects of spermine on the thermodynamics of the B-DNA to Z-DNA transition

1 reference

12 December 2020

Effects of chronically elevated growth hormone levels on polyamine metabolism in elderly transgenic mice

1 reference

12 December 2020

Ornithine decarboxylase overexpression is a sufficient condition for tumor promotion in mouse skin.

1 reference

12 December 2020

Polyamines regulate expression of the neoplastic phenotype in mouse skin.

1 reference

12 December 2020

10.1111/J.1582-4934.2005.TB00385.X

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6740286&resulttype=core&format=json

12 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6740286&resulttype=core&format=json

12 May 2020

1 reference